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| 1 | Pneumatosis cystoides intestinalis in scleroderma‐related conditions显示文摘 | A.Balbir‐Gurman O. R.Brook I.Chermesh Y.Braun‐Moscovici | 2012 | Internal Medicine Journal2012，，3： | 2 |
| 2 | Clinical outcomes for men with positive surgical margins after radical prostatectomy—results from the South Australian Prostate Cancer Clinical Outcomes Collaborative community-based registry显示文摘Objective Positive surgical margins(PSMs)after radical prostatectomy(RP)indicate failure of surgery to completely clear cancer.PSMs confer an increased risk of biochemical recurrence(BCR),but how more robust outcomes are affected is unclear.This study investigated factors associated with PSMs following RP and determined their impact on clinical outcomes(BCR,second treatment[radiotherapy and/or androgen deprivation therapy],and prostate cancer-specific mortality[PCSM]).Methods The study cohort included men diagnosed with prostate cancer(pT2-3b/N0/M0)between January 1998 and June 2016 who underwent RP from the South Australian Prostate Cancer Clinical Outcomes Collaborative database.Factors associated with risk of PSMs were identified using Poisson regression.The impact of PSMs on clinical outcomes(BCR,second treatment,and PCSM)was assessed using competing risk regression.Results Of the 2827 eligible participants,28%had PSMs—10%apical,6%bladder neck,17%posterolateral,and 5%at multiple locations.Median follow-up was 9.6 years with 81 deaths from prostate cancer recorded.Likelihood of PSM increased with higher pathological grade and pathological tumor stage,and greater tumour volume,but decreased with increasing surgeon volume(odds ratio[OR]:0.93;95%confidence interval[CI]:0.88-0.98,per 100 previous prostatectomies).PSMs were associated with increased risk of BCR(adjusted sub-distribution hazard ratio[sHR]2.5;95%CI 2.1-3.1)and second treatment(sHR 2.9;95%CI 2.4-3.5).Risk of BCR was increased similarly for each PSM location,but was higher for multiple margin sites.We found no association between PSMs and PCSM.Conclusion Our findings support previous research suggesting that PSMs are not independently associated with PCSM despite strong association with BCR.Reducing PSM rates remains an important objective,given the higher likelihood of secondary treatment with associated comorbidities. | Kerri R.Beckmann Michael E.O'Callaghan Andrew D.Vincent Kim L.Moretti Nicholas R.Brook | 2023 | Asian Journal of Urology2023，10，4： | 0 |
| 3 | 评估多污染物暴露和城市空气质量:污染物间的相互关系、邻里变异性和二氧化氮作为代替污染物显示文摘[背景]虽然城市空气污染物是包含多种成分的复杂组合,但是关于长期暴露对健康影响的研究往往集中在某单一污染物,将其作为整个混合物的代替指标。对于探究暴露中空间差异的流行病学研究,更好地了解成分污染物的浓度和相互关系将大有帮助,它可以阐明单个污染物指标,特别是二氧化氮(NO2),在多大程度上代表了多种污染混合物的空间格局。[目的]研究城市中空气污染物浓度和相互关系,了解认识城市空气污染混合物的性质。[方法]在2009年冬季、夏季和秋季的34天里,以高分辨率系统、动态地测量加拿大魁北克蒙特利尔市的23种空气污染物。[结果]污染水平以及不同污染物统计关联间随季节和邻里而变化。氮氧化物类(一氧化氮、二氧化氮、氮氧化物和总的氧化氮类)与测量的整套污染物指标之间的整体空间相关性最高。超细颗粒物和烃类有机气溶胶浓度(用作特定的交通颗粒物指标的派生指标)也具有非常高的相关性。[结论]本研究结果表明,无论是在时间还是空间上,多污染物的组合在城市中的变异很大,因此没有任何单一的污染物能够在所有条件下成为整个污染的完美替代指标。然而,根据整套污染物指标总体的平均空间相关性,氮氧化物类是户外城市空气污染混合物暴露空间变化的最佳指标。 | Ilan Levy Cristian Mihele Gang Lu Julie Narayan Jeffrey R.Brook | 2014 | 环境与职业医学2014，31，4： | 0 |
| 4 | A database of modeled gridded dry deposition velocities for 45 gaseous species and three particle size ranges across North America显示文摘The dry deposition process refers to the flux loss of an atmospheric pollutant due to uptake of the pollutant by the earth’s surfaces.Dry deposition flux of a chemical species is typically calculated as the product of its surface-layer concentration and its dry deposition velocity(V_(d)).Field measurement based V_(d) data are very scarce or do not exist for many chemical species considered in chemistry transport models.In the present study,gaseous and particulate dry deposition schemes were applied to generate a database of hourly V_(d) for 45 gaseous species and three particle size ranges for two years(2016–2017)at a 15 kmby 15 km horizontal resolution across North America.Hourly V_(d) of the 45 gaseous species ranged from<0.001 to 4.6 cm/sec across the whole domain,with chemical species-dependentmedian(mean)values being in the range of 0.018–1.37 cm/sec(0.05–1.43 cm/sec).The spatial distributions of the two-year average V_(d) showed values higher than 1–3 cm/sec for those soluble and reactive species over certain land types.Soluble species have the highest V_(d) over water surfaces,while insoluble but reactive species have the highest V_(d) over forests.Hourly V_(d) of PM_(2.5) across the whole domain ranged from 0.039 to 0.75 cm/sec with median(mean)value of 0.18(0.20)cm s^(−1),while the mean V_(d) for PM_(2.5)–10 is twice that of PM_(2.5).Uncertainties in the modeled V_(d) are typically on the order of a factor of 2.0 or larger,which needs to be considered when applying the dataset in other studies. | Leiming Zhang Zhuanshi He Zhiyong Wu Anne Marie Macdonald Jeffrey R.Brook Shailesh Kharol | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
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