| 1 | Controlled temperature-mediated curcumin release from magneto-thermal nanocarriers to kill bone tumors显示文摘Systemic chemotherapy has lost its position to treat cancer over the past years mainly due to drug resistance,side effects,and limited survival ratio.Among a plethora of local drug delivery systems to solve this issue,the combinatorial strategy of chemo-hyperthermia has recently received attention.Herein we developed a magneto-thermal nanocarrier consisted of superparamagnetic iron oxide nanoparticles(SPIONs)coated by a blend formulation of a three-block copolymer Pluronic F127 and F68 on the oleic acid(OA)in which Curcumin as a natural and chemical anti-cancer agent was loaded.The subsequent nanocarrier SPION@OA-F127/F68-Cur was designed with a controlled gelation temperature of the shell,which could consequently control the release of curcumin.The release was systematically studied as a function of temperature and pH,via response surface methodology(RSM).The bone tumor killing efficacy of the released curcumin from the carrier in combination with the hyperthermia was studied on MG-63 osteosarcoma cells through Alamar blue assay,live-dead staining and apoptosis caspase 3/7 activation kit.It was found that the shrinkage of the F127/F68 layer stimulated by elevated temperature in an alternative magnetic field caused the curcumin release.Although the maximum release concentration and cell death took place at 45℃,treatment at 41℃ was chosen as the optimum condition due to considerable cell apoptosis and lower side effects of mild hyperthermia.The cell metabolic activity results confirmed the synergistic effects of curcumin and hyperthermia in killing MG-63 osteosarcoma cells. | A.Khodaei F.Jahanmard H.R.Madaah Hosseini R.Bagheri A.Dabbagh H.Weinans Amin Yavari | 2022 | Bioactive Materials2022，7，5： | 0 |
| 2 | Analytical solution of multiple moving cracks in functionally graded piezoelectric strip显示文摘The dynamic behaviors of several moving cracks in a functionally graded piezoelectric(FGP) strip subjected to anti-plane mechanical loading and in-plane electrical loading are investigated. For the first time, the distributed dislocation technique is used to construct the integral equations for FGP materials, in which the unknown variables are the dislocation densities. With the dislocation densities, the field intensity factors are determined. Moreover, the effects of the speed of the crack propagation on the field intensity factors are studied. Several examples are solved, and the numerical results for the stress intensity factor and the electric displacement intensity factor are presented graphically finally. | R.BAGHERI M.AYATOLLAHI S.M.MOUSAVI | 2015 | Applied Mathematics and Mechanics(English Edition)2015，36，6： | 0 |
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