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| 1 | Targeting cell surface receptors for axon regeneration in the central nervous system显示文摘Axon regeneration in the CNS is largely unsuccessful due to excess inhibitory extrinsic factors within lesion sites together with an intrinsic inability of neurons to regrow following injury. Recent work demonstrates that forced expression of certain neuronal transmembrane receptors can recapitulate neuronal growth resulting in successful growth within and through inhibitory lesion environments. More specifically, neuronal expression of integrin receptors such as alpha9beta1 integrin which binds the extracellular matrix glycoprotein tenascin-C, trk receptors such as trk B which binds the neurotrophic factor BDNF, and receptor PTPσ which binds chondroitin sulphate proteoglycans, have all been show to significantly enhance regeneration of injured axons. We discuss how reintroduction of these receptors in damaged neurons facilitates signalling from the internal environment of the cell with the external environment of the lesion milieu, effectively resulting in growth and repair following injury. In summary, we suggest an appropriate balance of intrinsic and extrinsic factors are required to obtain substantial axon regeneration. | Menghon Cheah Melissa R.Andrews | 2016 | Neural Regeneration Research2016，11，12： | 3 |
| 2 | Advances in human stem cell therapies:pre-clinical studies and the outlook for central nervous system regeneration显示文摘Cell transplantation has come to the forefront of regenerative medicine alongside the discovery and application of stem cells in both research and clinical settings.There are several types of stem cells currently being used for pre-clinical regenerative therapies,each with unique characteristics,benefits and limitations.This brief review will focus on recent basic science advancements made with embryonic stem cells and induced pluripotent stem cells.Both embryonic stem cells and induced pluripotent stem cells provide platforms for new neurons to replace dead and/or dying cells following injury.Due to their capacity for reprogramming and differentiation into any neuronal type,research in preclinical rodent models has shown that embryonic stem cells and induced pluripotent stem cells can integrate,survive and form connections in the nervous system similar to de novo cells.Going forward however,there are some limitations to consider with the use of either stem cell type.Ethically,embryonic stem cells are not an ideal source of cells,genetically,induced pluripotent stem cells are not ideal in terms of personalized treatment for those with certain genetic diseases the latter of which may guide regenerative medicine away from personalized stem cell based therapies and into optimized stem cell banks.Nonetheless,the potential of these stem cells in central nervous system regenerative therapy is only beginning to be appreciated.For example,through genetic modification,stem cells serve as ideal platforms to reintroduce missing or downregulated molecules into the nervous system to further induce regenerative growth.In this review,we highlight the limitations of stem cell based therapies whilst discussing some of the means of overcoming these limitations. | Lindsey H.Forbes Melissa R.Andrews | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 3 | Assessing Organizational Performance:Exploring Differences Between Internal and External Measures显示文摘 | R.Andrews G.Boyne M.Moon | | 0，，02： | 1 |
| 4 | The Impact of Management on Administrative and Survey Measures of Organizational Performance显示文摘 | R.Andrews G.Boyne R.Walker | | 0，，02： | 1 |
| 5 | Centralization,Organizational Strategy,and Public Service Performance显示文摘 | R.Andrews G.Boyne J.Law | | 0，，01： | 1 |
| 6 | Better Public Services-The Moral Purpose of Public Management Research显示文摘 | R.Andrews G.Boyne | | 0，，03： | 1 |
| 7 | Restoring axonal localization and transport of transmembrane receptors to promote repair within the injured CNS: a critical step in CNS regeneration显示文摘Each neuronal subtype is distinct in how it develops,responds to environmental cues,and whether it is capable of mounting a regenerative response following injury.Although the adult central nervous system(CNS) does not regenerate,several experimental interventions have been trialled with successful albeit limited instances of axonal repair.We highlight here some of these approaches including extracellular matrix(ECM) modification,cellular grafting,gene therapy-induced replacement of proteins,as well as application of biomaterials.We also review the recent report demonstrating the failure of axonal localization and transport of growth-promoting receptors within certain classes of mature neurons.More specifically,we discuss an inability of integrin receptors to localize within the axonal compartment of mature motor neurons such as in the corticospinal and rubrospinal tracts,whereas in immature neurons of those pathways and in mature sensory tracts such as in the optic nerve and dorsal column pathways these receptors readily localize within axons.Furthermore we assert that this failure of axonal localization contributes to the intrinsic inability of axonal regeneration.We conclude by highlighting the necessity for both combined therapies as well as a targeted approach specific to both age and neuronal subtype will be required to induce substantial CNS repair. | Lindsey H.Forbes Melissa R.Andrews | 2017 | Neural Regeneration Research2017，12，1： | 1 |
| 8 | 利用电磁极化实现三倍无线通信容量显示文摘无线通信是现代信息基础设施的基本组成部分。无线带宽是珍贵的[1],这促使人们去仔细检视可用的使用电磁波的数据信道。传统方法是给每个频率分配一个信道,尽管很好理解平面波的两种极化状态[2]允许两种不同的信息信道,诸如极化分集技术已经利用了这一点[3]。 | Michael R.Andrews Partha P.Mitra Robert deCarvalho 张建强(翻译) 常雷(审校) | 2020 | 通信对抗2020，39，2： | 0 |
| 9 | 您享受到应得的服务了么?显示文摘在前四期的《中国高尔夫管理》中,我们主要论述了以下几个方面的问题。首先是选购球车的基本知识(《球车,从选购开始》44期),接下来是关于球车的基本动力选择(《选择电力驱动还是汽油动力》45期),再接着是关于维护电动球车电池的方式(《电动高尔夫球车的电池维护》46期),最后是关于刹车系统的养护问题(《球车的安全保障——制动器性能》47期)。 | Keith R.Andrews 夏魏(译) | 2008 | 中国高尔夫管理2008，，1： | 0 |
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