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		题名	作者	年代	出处	被引量
	1	Resistive humidity sensor based on vanadium complex films显示文摘A resistive-type relative humidity (RH) sensor based on vanadium complex (VO_2(3-fl)) film is reported inthisstudy.Gold electrodes were deposited on the glass substrates in a co-planar structure.A thin film of vanadium complex was coated as a humidity-sensing material on the top of the pre-patterned electrodes.The humidity-sensing principle of the sensor was based on the conductivity change of coated sensing element upon adsorption/desorption of water vapor. The resistance of the humidity sensor measured at 1 kHz decreased linearly with increasing the humidity in the range of 35%–70% RH. The overall resistance of the sensor decreases 11 times. An equivalent circuit for the VO_2(3-fl) based resistive-type humidity sensor was developed. The properties of the sensor studied in this work make it beneficial for use in the instruments for environmental monitoring of humidity.	Kh.S.Karimov M.Saleem M.Mahroof-Tahir R.Akram M.T.Saeed Chanee A.K.Niaz	2014	Journal of Semiconductors2014，35，9：	1
	2	Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease显示文摘Objective and Impact Statement.There is a need to develop platforms delineating inflammatory biology of the distal human lung.We describe a platform technology approach to detect in situ enzyme activity and observe drug inhibition in the distal human lung using a combination of matrix metalloproteinase(MMP)optical reporters,fibered confocal fluorescence microscopy(FCFM),and a bespoke delivery device.Introduction.The development of new therapeutic agents is hindered by the lack of in vivo in situ experimental methodologies that can rapidly evaluate the biological activity or drug-target engagement in patients.Methods.We optimised a novel highly quenched optical molecular reporter of enzyme activity(FIB One)and developed a translational pathway for in-human assessment.Results.We demonstrate the specificity for matrix metalloproteases(MMPs)2,9,and 13 and probe dequenching within physiological levels of MMPs and feasibility of imaging within whole lung models in preclinical settings.Subsequently,in a first-in-human exploratory experimental medicine study of patients with fibroproliferative lung disease,we demonstrate,through FCFM,the MMP activity in the alveolar space measured through FIB One fluorescence increase(with pharmacological inhibition).Conclusion.This translational in situ approach enables a new methodology to demonstrate active drug target effects of the distal lung and consequently may inform therapeutic drug development pathways.	Alicia Megia-Fernandez Adam Marshall Ahsan R.Akram Bethany Mills Sunay V.Chankeshwara Emma Scholefield Amy Miele Bruce C.McGorum Chesney Michaels Nathan Knighton Tom Vercauteren Francois Lacombe Veronique Dentan Annya M.Bruce Joanne Mair Robert Hitchcock Nik Hirani Chris Haslett Mark Bradley Kevin Dhaliwal	2021	Biomedical Engineering Frontiers2021，2，1：	0
	3	Erratum to “Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease”显示文摘In the research article“Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease”[1],the data availability statement was inadvertently omitted by the publisher.This has now been corrected in the PDF and HTML(full text).	Alicia Megia-Fernandez Adam Marshall Ahsan R.Akram Bethany Mills Sunay V.Chankeshwara Emma Scholefield Amy Miele Bruce C.McGorum Chesney Michaels Nathan Knighton Tom Vercauteren Francois Lacombe Veronique Dentan Annya M.Bruce Joanne Mair Robert Hitchcock Nik Hirani Chris Haslett Mark Bradley Kevin Dhaliwal	2023	Biomedical Engineering Frontiers2023，4，1：	0

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