|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | HBeAg阴性慢性乙型肝炎患者血清HBV前C区的序列分析显示文摘 | 方钟燎 庄辉 杨进业 葛宪民 王学燕 龚健 李荣成 Ling R Harrison TJ | 2002 | 中华实验和临床病毒学杂志2002，16，1： | 3 |
| 4 | Priming of the Cells: Hypoxic Preconditioning for Stem Cell Therapy显示文摘 | Zheng Z Wei Yan-Bing Zhu James Y Zhang Myles R McCrary Song Wang Yong-Bo Zhang Shan-Ping Yu Ling Wei | 2017 | Chinese Medical Journal2017，，19： | 3 |
| 5 | 简并引物在扩增GBV-C/HGVNS3高度变异区的应用显示文摘目的试图比较简并引物扩增GBV-C/HGVNS3变异较大的区域的作用。方法设计了简并引物和减温(touchdown)PCR扩增程序以对目的基因进行扩增,并对阳性PCR产物进行克隆及测序。结果该方法能够检测基因变异约达21%的区域。结论提示该法是一项有效的了解基因家系的技术。 | 王佑春 庄辉 李河民 张华远 R LING TJ HARRISON | 1998 | 中华微生物学和免疫学杂志1998，18，5： | 2 |
| 6 | Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets显示文摘 | T. A. Dayeh A. H. Olsson P. Volkov P. Almgren T. R?nn C. Ling | 2013 | Diabetologia2013，，5： | 2 |
| 7 | Genomic-Sequence Comparison of Two Unrelated Isolates of the Human Gastric Pathogen Helicobacterpylori 显示文摘 | Alm R A Ling L L Moir D T | 1999 | Nature1999，397，14： | 1 |
| 8 | Direct numerical simulation of a three-dimensional temporal mixing layer with particle dispersion显示文摘 | Ling W Chung J N Troutt T R | 1998 | J Fluid Mech1998，358，： | 1 |
| 9 | Surface glycoprotein modulating drug permeability in chinese hamster ovary cell mutants 显示文摘 | Juliano R L Ling V A | 1976 | Biochem Biophys Acta1976，455，： | 1 |
| 10 | Direct numerical simulation of a three-dimensional temporal mixing layer with particle dispersion 显示文摘 | Ling W Chung J N Troutt T R | 1998 | Journal of Fluid Mechanics1998，358，： | 1 |
| 11 | Genetic analysis of cold tolerance dur-ing vegetative growth in tomato,Lycopersicon esculentum Mill显示文摘 | FOOLAD M R LING Y | 2001 | Euphytica2001，，122： | 1 |
| 12 | Multiscale distance matrix for fast plant leaf recognition显示文摘 | HU R JIA W LING H | 2012 | IEEE Transactions on Image Processing2012，21，11： | 1 |
| 13 | Intemal Marketing and Customer Driven Wavefronts显示文摘 | Brooks R F I N Lings M A Botschen | 1999 | The Service Industries Journal1999，19，4： | 1 |
| 14 | An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast 显示文摘 | Bauman R A Ling G Tong L | 2009 | J Neurotraurna2009，26，6： | 1 |
| 15 | Testosterone enhances apoptosis-related damage in human vascular endothelial cells显示文摘 | Ling S Dai A Williams M R | 2002 | Endocrinology2002，143，3： | 1 |
| 16 | Chinese Implicit Leadership Theory显示文摘 | Ling W Q Chia R C Fang L L | 2000 | The Journal of Social Psychology2000，140，6： | 1 |
| 17 | Pricing mortgage -backed securities: Integrating optimal call and empirical models of prepayment 显示文摘 | Archer W R Ling D C | 1993 | AREUEA1993，21，2： | 1 |
| 18 | Fixation of ankle fragility fractures by tibiotalocalcaneal nail显示文摘 | Amirfeyz R Bacon A Ling J | 2008 | Archives of Orthopaedic and Trauma Surgery2008，，04： | 1 |
| 19 | CCAT2,a novel noneoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer显示文摘 | Ling H Spizzo R Atlasi Y | 2013 | Genome Res2013，23，9： | 1 |
| 20 | Differential develop- ment of acute tolerance to analgesia, respiratory depression, gas- trointestinal transit and hormone release in a morphine infusion model显示文摘 | LING GS PAUL D SIMANTOV R | 1989 | Life Sci1989，45，18： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员