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| 1 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 2 | Proposed approach to the challenging management of progressive gastroesophageal reflux disease显示文摘The progression of gastroesophageal reflux disease(GERD) in patients who are taking proton pump inhibitors(PPIs) has been reported by several investigators,leading to concerns that PPI therapy does not address all aspects of the disease.Patients who are at risk of progression need to be identified early in the course of their disease in order to receive preventive treatment.A review of the literature on GERD progression to Barrett's esophagus and the associated physiological and pathological changes was performed and risk factors for progression were identified.In addition,a potential approach to the prevention of progression is discussed.Current evidence shows that GERD can progress;however,patients at risk of progression may not be identified early enough for it to be prevented.Biopsies of the squamocolumnar junction that show microscopic intestinalization of metaplastic cardiac mucosa in endoscopically normal patients are predictive of future visible Barrett's esophagus,and an indicator of GERD progression.Such changes can be identified only through biopsy,which is not currently recommended for endoscopically normal patients.GERD treatment should aim to prevent progression.We propose that endoscopically normal patients who partially respond or do not respond to PPI therapy undergo routine biopsies at the squamocolumnar junction to identify histological changes that may predict future progression.This will allow earlier intervention,aimed at preventing Barrett's esophagus. | Joachim Labenz Parakrama T Chandrasoma Laura J Knapp Tom R DeMeester | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 7 |
| 3 | Evidence for internal dielectronic excitation of slow highly charged Uranium ions显示文摘 | Schuch R Schneider D Knapp D A | 1993 | Phys Rev Letter1993，70，： | 1 |
| 4 | Effects of activated carbon surface chemistry and pore structure on the adsorption of organic contaminants from aqueous solution显示文摘 | Li Lei Patricia A Quinlivan Detlif R U Knappe | 2002 | Carbon2002，40，： | 1 |
| 5 | Energy distribution in wavelets and implications on resolving power显示文摘 | Knapp R W | 1993 | Geophysics1993，58，1： | 1 |
| 6 | An evaluation of the quality of drug-related services in neighborhood pharmacies显示文摘 | Knapp D Knapp D | 1975 | Drugs Health Care1975，2，： | 1 |
| 7 | Synthesis and structure of a copper sulfate/kinked organo di- imine coordination显示文摘 | Warren R Knapp Ronald M Supkowski Robert L LaDuca | 2008 | Inorg Chem Commun2008，11，10： | 1 |
| 8 | A Psychology of Rumor显示文摘 | Knapp R | 1944 | Public Relations Quarterly1944，8，1： | 1 |
| 9 | Effects of activated carbon surface chemistry and pole atrueture on the adsorption of organic contaminanta from aqueous solution显示文摘 | Quirdivan P A Knappe D R U | 2002 | Carbon2002，40，12： | 1 |
| 10 | New onset hypertension after extracorporeal shock wave lithotfipsy:age related incidence and prediction by intrarenal resistive index显示文摘 | Janetschek G Frauseher F Knapp R | 1997 | J Urol1997，158，： | 1 |
| 11 | Effects of activated carbon surface chemistry and pore structure on the ad- sorption of organic contaminants from aqueous solution 显示文摘 | Li L Quinlivan P A Knappe D R U | 2002 | Carbon2002，40，12： | 1 |
| 12 | Measurement and analysis of audible noise显示文摘 | Popeck R A Knapp R F | 1981 | IEEE Transactions on Power Apparatus and Systems1981，100，4： | 1 |
| 13 | Biofilm Development on Stainless in Mains Water显示文摘 | PERCIVAL S L KNAPP J S EDYVEAN R | 1998 | Water Research1998，32，1： | 1 |
| 14 | Electromagnetically induced transparency and absorption in a standing wave 显示文摘 | Affolderbach C Knappe S Wynands R | 2002 | Phys Rev A2002，65，04： | 1 |
| 15 | Effects of somatotropin and substrates on patterns of liver me- tabolism in lactating dairy cattle 显示文摘 | KNAPP J R FREETLY H C REIS B L | 1992 | Journal of Dairy Science1992，75，4： | 1 |
| 16 | Transport and release of chemicals from plastics to the environment and to wild- life显示文摘 | Teuten E L Saquing J M Knappe D R U | 2009 | Philosophical Transactions of the Royal Society of London B2009，364，1526： | 1 |
| 17 | High-resolution common-depth-point seismic reflection profiling: Field acquisition parameter design 显示文摘 | Knapp R W Steeples D W | 1986 | Geophysics1986，51，2： | 1 |
| 18 | Evolution of rDNA in Nicotiana allopolyploids: a potential link between rDNA homogenization and epigenetics 显示文摘 | Kovarik A Dadejova M Lim Y K Chase M W Clarkson J J Knapp S Leitch A R | 2008 | Ann Bot (Lond)2008，101，6： | 1 |
| 19 | Discovery of potent and selective small-molecule PAR-2 agonists 显示文摘 | Seitzberg J G Knapp A E Olsson R | 2008 | J Med Chem2008，51，18： | 1 |
| 20 | Geophysical evi dence for gas hydrates in the deep water of the South Caspian Basin, Azerbaijan显示文摘 | Diaconescu C C Kieckhefer R M Knapp J H | 2001 | Marine and Petroleum Geology2001，18，： | 1 |
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