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291篇 您的检索式：作者名="Quirion"

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	题名	作者	年代	出处	被引量
1	神经生长因子诱导神经干细胞分化的作用机制探讨显示文摘目的探讨神经生长因子(NGF)对体外培养的小鼠神经干细胞(NSCs)分化为神经元的作用及可能机制。方法以无血清培养法从孕13~14 d的昆明小鼠大脑皮质分离培养获得NSCs,传至3代后,进行NGF处理,并对培养的细胞进行MAP-2免疫细胞化学染色,荧光显微镜下对MAP-2阳性细胞进行计数。同时运用蛋白免疫印迹法(Western blot)考察NGF对TrkA、Akt、Erk磷酸化水平的影响;在研究NGF作用的信号转导通路时,预先给予各种信号通路抑制剂处理,再进行NGF干预,通过MAP-2染色及Western blot考察NGF促进神经干细胞分化为神经元的信号通路。结果 NGF可以显著促使NSCs分化为神经元并可以促进TrkA、Akt和Erk的磷酸化,呈现剂量和时间依赖性;各种通路抑制剂结果显示PI3K/Akt抑制剂可以阻断NGF对Akt的磷酸化作用,同时阻断了NGF对NSCs的促分化作用,MAPK抑制剂处理可以阻断NGF对Erk的磷酸化作用,但未见明显阻断NGF的促分化作用。结论 NGF可以促进NSCs分化为神经元,其作用机制可能与激活PI3K/Akt信号通路有关。	苏肖英汪海涛孟茜 Remi Quirion 郑文华	2012	广东医学2012，33，1：	11
2	The molecular pharmacology of CGRP and related peptide receptor subtypes 显示文摘	Juaneda C Dumont Y Quirion R	2000	Trends Pharmacol Sci2000，21，11：	1
3	Aging and long-term caloric restriction regulate neuropeptide Y receptor subtype densities in the rat brain显示文摘	Veyrat-Durebex C Quirion R Ferland G	2013	Neuropeptides2013，47，3：	1
4	The pharmacology of adrenomedullin 2/intermedin显示文摘	Hong YG Hay DL Quirion R	2012	Br J Pharmacol2012，166，1：	1
5	Neuroprotective and neurorescuing effect of isoform-specific nitric oxide synthase inhitors, nitric oxide scavenger, and antioxidant against beta-amyloid toxicity显示文摘	Law A Gauthier S Quirion R	2001	Br J Pharmacol2001，133，：	1
6	Recognizing and treating upper extremity lymphede- ma in postmastectomy / lumpectomy patients : a guide for pri- mary care providers显示文摘	Quirion E	2010	J Am Acad Nurse Pract2010，22，9：	1
7	Cutting edge: Ikaros is a regulator of Th2 cell differentiation 显示文摘	Quirion MR Gregory GD Umetsu SE	2009	J Immunol2009，182，2：	1
8	Stimulation of protein kinase C modulates insulin-like growth factor-l-induced akt activation in PC12 cells 显示文摘	Zheng W H Kar S Quirion R	2000	J Biol Chem2000，275，13：	1
9	Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons显示文摘	Zheng WH Quirion R	2000	Br J Pharmacol2000，131，：	1
10	Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons显示文摘	Zheng WH Kar S Quirion R	2002	Mol Pharmacol2002，62，2：	1
11	Neuropeptide Y (NPY) and depression:from animal studies to the human condition 显示文摘	Redrobe JP Dumont Y Quirion R	2002	Life Sci2002，71，25：	1
12	Neuropeptidey (NPY) and depression:from animal studies to the human condition显示文摘	REDROBE J P DUMONTY QUIRION R	2002	Life Scj2002，71，25：	1
13	Does COX2-dependent PGE2 play a role in neuropathic pain? 显示文摘	Ma W Quirion R	2008	Neurosci Lett2008，437，：	1
14	Prices versus quantities in a second-best setting显示文摘	Philippe Quirion	2004	Environmental & Resource Economics2004，29，3：	1
15	The Cinkgo biloba extract (EGb761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C 显示文摘	Bastianetto S Zheng W H Quirion R	2000	J Neurochem2000，74，6：	1
16	The common environmental pollutant dioxin-induced memory deficitsby altering estrogen pathways and a major route of retinol transport involving transthyretin显示文摘	BROUILLETTE J QUIRION R	2008	Neurotoxicology2008，29，2：	1
17	Polyphenols as potential inhibitors of amyloid aggregation and toxicity : possible significance to Alzheimer' s disease 显示文摘	Bastianetto S Krantic S Quirion R	2008	Mini Rev Med Chem2008，8，5：	1
18	The Ginkgo biliba exfract (EGB>61) Protects and resues hippocampal cell again 5t nitric Dxide-induced toxity:involement of its flavonoid constituents and protein kinase显示文摘	Bastianettos Zheng WH Quirion R	2000	Neurochem2000，74，：	1
19	Alfalfa root flavonoid production is nitrogen regulated显示文摘	CORONADO C ZUANAZZI J A S SALLAUD C QUIRION J C ESNAULT R HUSSON H P KONDOROSI A RATET P	1995	Plant Physiology1995，108，：	1
20	Neurotensin regulation of endogenous acetylcholine release from rat striatal slices is independent of dopaminergic tone显示文摘	Lapchak PA Araujo DM Quirion R	1991	J Neurochem1991，56，2：	1

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