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| 1 | Role of dynamic perfusion magnetic resonance imaging in patients with local advanced rectal cancer显示文摘BACKGROUND The management of rectal cancer patients is mainly based on the use of the magnetic resonance imaging(MRI)technique as a diagnostic tool for both staging and restaging.After treatment,to date,the evaluation of complete response is based on the histopathology assessment by using different tumor regression grade(TRG)features(e.g.,Dworak or Mandard classifications).While from the radiological point of view,the main attention for the prediction of a complete response after chemotherapy treatment focuses on MRI and the potential role of diffusion-weighted images and perfusion imaging represented by dynamiccontrast enhanced MRI.The main aim is to find a reliable tool to predict tumor response in comparison to histopathologic findings.AIM To investigate the value of dynamic contrast-enhanced perfusion-MRI parameters in the evaluation of the healthy rectal wall and tumor response to chemo-radiation therapy in patients with local advanced rectal cancer with histopathologic correlation.METHODS Twenty-eight patients with biopsy-proven rectal adenocarcinoma who underwent a dynamic contrast-enhanced MR study performed on a 1.5 T MRI system(Achieva,Philips),before(MR1)and after chemoradiation therapy(MR2),were enrolled in this study.The protocol included T1 gadolinium enhanced THRIVE sequences acquired on axial planes.A dedicated workstation was used to generate color permeability maps.Region of interest was manually drawn on tumor tissue and normal rectal wall,hence the following parameters were calculated and statistically analyzed:Relative arterial enhancement(RAE),relative venous enhancement(RVE),relative late enhancement(RLE),maximum enhancement(ME),time to peak and area under the curve(AUC).Perfusion parameters were related to pathologic TRG(Mandard’s criteria;TRG1=complete regression,TRG5=no regression).RESULTS Ten tumors(36%)showed complete or subtotal regression(TRG1-2)at histology and classified as responders;18 tumors(64%)were classified as non-responders(TRG3-5).Perfusion MRI parameters were significantly higher in the tumor tissue than in the healthy tissue in MR1(P<0.05).At baseline(MR1),no significant difference in perfusion parameters was found between responders and nonresponders.After chemo-radiation therapy,at MR2,responders showed significantly(P<0.05)lower perfusion values[RAE(%)54±20;RVE(%)73±24;RLE(%):82±29;ME(%):904±429]compared to non-responders[RAE(%):129±45;RVE(%):154±39;RLE(%):164±35;ME(%):1714±427].Moreover,in responders group perfusion values decreased significantly at MR2[RAE(%):54±20;RVE(%):73±24;RLE(%):82±29;ME(%):904±429]compared to the corresponding perfusion values at MR1[RAE(%):115±21;RVE(%):119±21;RLE(%):111±74;ME(%):1060±325];(P<0.05).Concerning the time-intensity curves,the AUC at MR2 showed significant difference(P=0.03)between responders and non-responders[AUC(mm2×10-3)121±50 vs 258±86],with lower AUC values of the tumor tissue in responders compared to nonresponders.In non-responders,there were no significant differences between perfusion values at MR1 and MR2.CONCLUSION Dynamic contrast perfusion-MRI analysis represents a complementary diagnostic tool for identifying vascularity characteristics of tumor tissue in local advanced rectal cancer,useful in the assessment of treatment response. | Davide Ippolito Silvia Girolama Drago Anna Pecorelli Cesare Maino Giulia Querques Ilaria Mariani Cammillo Talei Franzesi Sandro Sironi | 2020 | World Journal of Gastroenterology2020，26，20： | 3 |
| 2 | Disordered consciousness: delirium in the intensive care unit 显示文摘 | J Querques | 2006 | Seminars in Anesthesia Perioperative Medicine and Pain2006，25，4： | 1 |
| 3 | The spectrum of subclinical Best vitelliform macular dystrophy in subjects with mutations in BEST1 gene 显示文摘 | Querques G Zerbib J Santacroce R | 2011 | Invest Ophthalmol Vis Sci2011，52，7： | 1 |
| 4 | Hypertension in hemodialysis patients显示文摘 | Querques M Manunta P | 2010 | Minerva Urol Nefrol2010，62，1： | 1 |
| 5 | A preliminary study on geno- type-independent Agrobacterium-mediated transformation method to obtain genetically engineered apricot plants显示文摘 | WANG H NORTES MD FAIZE M FAIZE L LOPEZ-NOGUERA S GARCIA-ALMODOVAR R C PADILLA I M G ALBUR- QUERQUE N PETRI C BURGOS L | 2009 | Acta Hort2009，839，： | 1 |
| 6 | Intravitreal ranibizumab injec- tion for nonarteritic ischemic optic neuropathy显示文摘 | Pece A Querques G Quinto A | 2010 | Journal of Ocular Pharmacology and Therapeutics2010，26，5： | 1 |
| 7 | North American Ginseng(Panax quinquefolius)prevents hyperglycemia and associated pancreatic abnormalities in diabetes显示文摘 | Sen S Querques MA Chakrabarti S | 2013 | J Med Food2013，16，7： | 1 |
| 8 | Enhanced Depth Imaging Optical Coherence Tomography in Type 2 Diabetes 显示文摘 | Giuseppe Querques Rosangela Lattanzio | 2012 | Invest Oph- thalmol Vis Sei2012，53，6： | 1 |
| 9 | Enhanced depth imaging optical coherence tomography in type 2 diabetes显示文摘 | Querques G Lattanzio R Querques L | | 0，，： | 1 |
| 10 | Monitoring of central retinal artery and vein with color doppler ultrasound during heart surgery as an alternative to transcranial doppler ultrasonography: A case report显示文摘 | Massimo Venturini Massimo Zambon Giulia Cristel Giulia Agostini Giulia Querques Michele Colombo Stefano Benussi Giovanni Landoni Alberto Zangrillo Alessandro Maschio | 2014 | J. Clin. Ultrasound2014，，2： | 1 |
| 11 | Primitive retinal vascular abnormalities:tu- mors and telangiectasias显示文摘 | Knutsson KA De Benedetto U Querques G Del Turco C Ban- dello F Lattanzio R | 2012 | Ophthalmologica2012，228，2： | 1 |
| 12 | Wheat growth and yield responses to bioehar addition under Mediterranean climate conditions 显示文摘 | Olmo M Albm'querque J A Bapr N V | 2014 | Biology and Fertility of Soils2014，50，8： | 1 |
| 13 | High-resolution spectral domain optical coherence tomography features in adult onset foveomacularvitelliform dystrophy显示文摘 | Puche N Querques G Benhamou N Tick S Mimoun G Martinelli D et ai | 2010 | Br J Ophthalrrwl2010，94，9： | 1 |
| 14 | High-resolution spectral domain optical coherence tomography features in adult onset foveomacular vitelliform dystrophy 显示文摘 | Puche N Querques G Benhamou N | 2010 | Br J Ophthalmol2010，94，： | 1 |
| 15 | Incidence and treat- ment of diplopia after three-wall orbital decompression in Graves' ophthalmopathy 显示文摘 | Russo V Querques G Primavera V | 2004 | J PediatrOphthalmol Strabismus2004，41，4： | 1 |
| 16 | Short-term fluctuation of diabetic macuIar edema after intravitreal ranibizumab injec- tion显示文摘 | Querques G Bux A V Martinelli D | 2009 | Retina2009，29，9： | 1 |
| 17 | Intravitreal pegaptanib sodium Macugen for diabetic macular oedema 显示文摘 | Querques G Bux AV MartineUi D Iaculli C Noci ND | 2009 | Acta Ophthalmol2009，87，6： | 1 |
| 18 | Age-related macular degeneration显示文摘 | Querques G Avellis FO Querques L | 2011 | Clin Ophthalmo12011，，： | 1 |
| 19 | Spectral-Domian versus time domain optical coherence tomography before and after ranibizumab for age-related macular degeneration 显示文摘 | Querques G Forte R Berboucha E | 2011 | Ophthalmic Res2011，46，： | 1 |
| 20 | An approach to the patient with dys- regulated mood: major depression and bipolar disorder 显示文摘 | QUERQUES J KONTOS N | 2010 | Med Clin North Am2010，94，6： | 1 |
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