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1篇 您的检索式：作者名="Quanfeng Deng"

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		题名	作者	年代	出处	被引量
	1	3D bioprinted breast tumor model for structure–activity relationship study显示文摘In this paper,we present a 3D printed tumor spheroidal model suitable for drug discovery.This model is based on a hydroxyethyl cellulose/alginate/gelatin(HCSG)composite biomaterial that has three distinct properties:(1)the HCSG is similar to the commercial basement membrane extract in Ki67,MUC1,and PARP1 expressions of MCF-7 cells for embedding culture;(2)the HCSG is printable at room temperature;and(3)the HCSG can be large-scale manufactured at an ultralow cost.We printed a 3D MCF-7 spheroid model with HCSG and characterized it in terms of cell viability,spheroid size,key protein expression,and mitochondrial metabolic activity.We used the 3D MCF-7 spheroid model to evaluate the anti-breast cancer activity of 13 amino acid-based flavone phosphoramidates and found that the alanine structure induced a stronger drug resistance,whereas phenylalanine hardly caused drug resistance in the MCF-7 cells.This is the first time that 3D bioprinting technology has been used in a structure–activity relationship study.	Xiaorui Li Quanfeng Deng Tiantian Zhuang Yao Lu Tingjiao Liu Weijie Zhao Bingcheng Lin Yong Luo Xiuli Zhang	2020	Bio-Design and Manufacturing2020，3，4：	0

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