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| 1 | Preliminary Study on Mouse Interleukin-21 Application in Tumor Gene Therapy显示文摘Interleukin-21 (IL-21) is a recently characterized T cell-derived cytokine with a significant homology to IL-2,IL-4 and IL-15. To determine whether IL-21 has broad immunoregulatory activity and can stimulate durable antitumour responses, we constructed mouse IL-21 (mIL-21) recombinant plasmid and evaluated its antitumor efficacy. Mouse IL-21 cDNA was amplified from Con A-activated mouse T cells by RT-PCR. Recombinant pcDNA3.1/mIL-21 was constructed and transfected into Sp2/0 cells. Mouse IL-21 expression was analyzed by Western blotting and its activities were detected by 3H-TdR incorporation and MTT assay. The recombinant pcDNA3.1/mIL-21 was injected s.c. into tumor lump. Tumor size, weight, the activities of CTLs, NK cells and LAK cells and serum IFN-γlevel were measured for evaluating mIL-21 mediated antitumor responses. The results indicated that mIL-21 was correctly expressed in Sp2/0 cells and it can improve the proliferation of T cells and B cells, and enhance NK cytotoxic activity in vitro. The activities of CTL and NK cells, and serum IFN-γlevel were significantly improved, furthermore the tumor growth was obviously suppressed in pcDNA3.1/mIL-21 treated mice. However, the LAK activity did not alter significantly. Taken together, this study suggests that the injection with recombinant plasmid containing mIL-21 is a potential approach for tumor gene therapy. Cellular & Molecular Immunology. 2004;1(6):461-466. | JunDou GuobinChen JingWangt FengshuZhao JunsongChen XuesongFang QuanTang LiliChu | 2004 | Cellular & Molecular Immunology2004，1，6： | 14 |
| 2 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 3 | Novel Constructs of Tuberculosis Gene Vaccine and Its Immune Effect on Mice显示文摘A novel tuberculosis (TB) gene vaccine containing mouse granulocyte macrophage-colony stimulating factor (mGM-CSF) and a TB antigen (Ag85A) was developed in this study. The genes encoding Ag85A and mGM-CSF were amplified by PCR respectively from the Ag85A-containing pBSby5 and pC-mGM-CSF. The genes were then cloned into two different polylinker sites of plasmid pIRES, forming a novel TB gene vaccine construct pI85AGM.Following transfection of pI85AGM plasmid into 7721 cell line by LipofectamineTM, the expression of Ag85A and GM-CSF proteins was identified by Western blotting or RT-PCR. Then Balb/c mice were inoculated with the recombinant pI85AGM, pI85A, pIGM or plasmid alone, respectively. The activities of CTL, NK cells and the Ag85A-stimulated proliferation of spleen cells were measured by MTT method. The serum antibody against Ag85A was detected by ELISA. The results showed that the Ag85A and GM-CSF proteins could be expressed in 7721 cell line and the activity of CTLs and the proliferation of spleen cells were significantly increased in the pI85AGM-immunized mice, indicating that the pI85AGM-immunized mice could generate specific immune responses to Ag85A. This study might provide possibility for developing novel anti-TB gene vaccine. | JunDou JunsongChen JingWang GuobinChen FengshuZhao QuanTang XuesongFang LiliChu MengPan | 2005 | Cellular & Molecular Immunology2005，2，1： | 4 |
| 4 | 6 - 20 Primary Design of a C-band Traveling-wave Cell显示文摘 | Wang Yanru Zhang Zimin Cao Shuchun Shen Xiaokang Zhao Quantang Jing Yi Zong Yang | 2013 | IMP & HIRFL Annual Report2013，，1： | 2 |
| 5 | Mechanistic study of continuous polishing显示文摘To establish the mechanism of surface change in a continuous polishing system, an ideal mathematical model is built based on Winkler's hypothesis and the Preston equation. The basic features of the model are the change rates in the surface peak–valley(PV) values of the workpiece, conditioning disk and pitch lap, rather than the specific surface shapes. In addition, an equilibrium state exists in the system, indicating that the surface change rates are all zero. Under equilibrium, the surface of the lap could remain flat, and it is insensitive to the surface error of the workpiece. These characteristics lay the theoretical foundations for high-efficiency and high-precision polishing. The methods to obtain an equilibrium state with flat surfaces are then proposed and confirmed experimentally. High-precision surfaces better thanλ/10(λ = 632.8 nm) are consistently produced experimentally. | Xiang Jiao Jianqiang Zhu Quantang Fan Yangshuai Li | 2015 | High Power Laser Science and Engineering2015，3，2： | 1 |
| 6 | Mechanism research of the impact of heterogeneity on the low permeability reservoir recovery显示文摘 | PAN Ling FANG Quantang DUAN Yonggang | 2012 | Journal of Southwest Petroleum University(Science&Technology Edition)2012，34，3： | 1 |
| 7 | 6 - 30 Electric Field Measurement Results and Analysis of PLIA显示文摘 | Shen Xiaokang Zhang Zimin Cao Shuchun Zhao Hongwei Wang Bo Shen Xiaoli Zhao Quantang Liu Ming Jing Yi | 2012 | IMP & HIRFL Annual Report2012，，1： | 1 |
| 8 | 6-45 Brief Introduction of IMP Electron Linear Accelerator Development and Its Applications显示文摘An electron linear accelerator (e-LINAC) is under designing and constructing in IMP for various imaging diagnostics application. The primary layout design is shown in Fig. 1. The e-LINAC is based on two kinds of electron guns, thermionic radio frequency (RF) gun for high average current and photocathode RF gun for ultra-short bunch length, which are able to provide various beam parameters and can satisfy requirement of the beam parameters from many applications. | Zhang Zimin Zhao Quantang Cao Shuchun Shen Xiaokan Zong Yang Zhu Yunliang Zhou Youwei Gai Wei | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 9 | 6-46 Research Progress of a 100 MeV Electron Linac for High Energy Electron Radiography显示文摘High Energy Electron Radiography (HEER) is a new method suitable for High Energy Density Physics (HEDP) research that uses a high energy electron beam as a probe for time resolved imaging measurements of high energy density processes in materials[1]. A high energy electron imaging research platform based on a 100 MeV Electron Linac (e-Linac) which was designed for experimental research of HEER has been proposed by Electron Accelerator Group in IMP. This e-Linac has two injection beam lines. One is a thermionic RF gun with Alpha magnet and quadrupole magnets, and the other is a photo-cathode RF gun with emittance compensation solenoid(Fig. 1), and parameters details is shown in Table 1. The experimental terminals of this e-linac have been designed for HEER and the Thick Target X-ray imaging. | Cao Shuchun Zhang Zimin Shen Xiaokang Liu Ming Zong Yang Zhu Yunliang Zhou Youwei Wang Yanru Zhang Xiaoming Li Zhongping Zhao Quantang Xiao Rongqing Jing Yi Gai Wei | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 10 | 6-47 Primary Research of ILC Positron Source Target Cooling显示文摘In recent years, the idea for undulator based Positron source had become a current design for international linear Collider (ILC). This design is that the beam from the electron main linac passes through a long helical undulator to generate a highly polarized and multi-Mev photon beam which hits a thin metal rotating target to generate showers of Positron[1]. During this procedure, the multi-Kev energy Positron will heat target and then damage the rotating target system[2]. | Zhang Xiaoming Zhang Zimin Cao Shuchun Shen Xiaokang Zhao Quantang Zong Yang Wang Yanru | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 11 | 6-49 Primary Design and Simulation of LEBT for High Energy Electron Radiography显示文摘At the beginning of 2013, the Institute of Modern Physics proposed to develop electron radiography technique based on high-energy and short-pulsed electron accelerator, which is applied to high energy density state/thick target diagnostics[1]. A low energy beam transport system (LEBT) was designed to matching the transmission between the gun and the LINAC. | Zhu Yunliang Zhang Zimin Cao Shuchun Liu Ming Shen Xiaokang Zong Yang Zhang Xiaoming Wang Yanru Zhou Youwei Li Zhongping Zhao Quantang Xiao Rongqing Jing Yi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 12 | 4-23 An Initiative Design of High Energy Electron Radiography with Ultrahigh Spatial and Temporal Resolution显示文摘In general, high energy density matter can only be transiently produced in the laboratory on a time scale ofnanoseconds. In addition, the pressure in a high energy density sample exceeds 1 Mbar, thus the hydro-dynamicresponse of the sample is a high expansion velocity in the range of km/s (or m/ns). Therefore diagnostics whichare capable of high time resolution (< ns) and high space resolution (< 10 m) are needed. Here, we present ascheme that uses a high energy electron beam as a probe for dynamic imaging measurements of high energy densityprocesses in materials with spatial, temporal resolution and frame rate in the order of 1 m, 1 ps and 1010 FPS,respectively.The device uses an e-LINAC (electron Linear Accelerator), which can produce electron beams with bunchintensity ranging from a few pC to 100 nC, bunch length and bunch interval of 1 and 100 ps in minimum, respectively.The beam energy can be increased easily from a few MeV to GeV by adding more accelerating sections. Detailscan be found in Ref. [1]. | Zhao Yongtao Zhang Zimin Gai Wei Du Yingchao Cheng Rui Cao Shuchun Zhao Quantang Zhou Xianming Tang Chuanxiang Zhan Wenlong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 13 | 4-29 Step-target Design for High Energy Electron Radiography Research显示文摘High energy proton beam has the long penetration length in solid matter and it could produce the radiographsand indicate the tomography and material properties inside of the specimen. Considering the expensive coststo construct a high energy proton accelerator, the other candidate of high energy electron beam becomes moreacceptable[1??3]. Due to the high spatial and temperal resolution of high energy electron beam. It is a power tool todiagnose the inner structure change during the high energy density matter production and the inertial confinementfusion process. In order to study the density resolution of the high energy electron beam radiography, a step-targetwas designed and produced. The structure and the target pictures are shown in Fig. 1 and the Si targets withdifferent slot-width were produced by using the microetch technics. | Cheng Rui Zhao Yongtao Zhang Ziming Gai Wei Du Yingchao Cao Shuchun Zhou Xianming Zhao Quantang Shen Xiaokang Zong Yang Wang Yangru Xiao Jiahao Li Haixia | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 14 | 6-17 Research Progress of High Energy Electron Radiography显示文摘High Energy Density Physics (HEDP) aims to study the properties of matter under extreme states of temperatureand pressure. The pressure in a high energy density sample exceeds 1 Mbar (100 GPa), thus the hydrodynamicresponse of the sample is a high expansion velocity in the range of km/s (m/ns). Therefore, diagnostics which arecapable of high time resolution (< ns) and space resolution (10 m) are needed. High Energy Electron Radiography(HEER) is a new method suitable for HEDP research that uses a high energy electron beam as a probe for timeresolved imaging measurements of high energy density processes in materials. The device uses an electron bunchtrain with a flexible time structure penetrating a time varying high density target. The electron bunch-lets, eacha few ps long and with charges nC is suitable, traverses the HEDP target where the electrons are scattered bythe nuclei. The angular distribution depends on the density and thickness of the target. The scattered electronsthen travel through the point-to-point imaging lattice with a suitable magnification. A small aperture is used tocollimate the scattered electron beam for off axis particles and bremsstrahlung photons, and the target image willbe detected by a luminescent screen located after the imaging lattice, as shown in the Fig. 1. | Cao Shuchun Zhang Ziming Shen Xiaokang Zhao Quantang Liu Ming Wang Yanru Zong Yang Zhang Xiaoming Li Zhongping Xiao Rongqing Jing Yi Wei Gai | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 15 | 6-18 Development of Cooling Technology research for ILC Undulator Based Positron Source Target System显示文摘In the recent years, the idea for undulator based positron source had became a current design for internationallinear collider (ILC). This design is that the beam from the electron main linac passes through a long helical undu-lator to generate a highly polarized and multi-Mev photon beam which hits a thin metal rotating target to generateshowers of positron[1]. In this progress, the multi-Kev energy deposition will heat target and then damage therotating target system[2]. | Zhang Xiaoming Zhang Zimin Wang Li Cao Shuchun Zhao Quantang Shen Xiaokang Li Zhongpin Zong Yang Wang Yanru | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 16 | 6-19 Development of the Simulation of C-band显示文摘The program about the C-band linac for high energy density physics needs a high current photocathode electrongun with very short pulse which is designed in IMP. The quantity of the electric charge is 1nC per pulse, and thepulse width is several ps. The cavity about the gun is formed by a whole cell cavity and a 0.6 cell cavity. The RFcharacteristic about the 1.6 cell cavity of the electron gun is simulated with Superfish[1] and Parmela.Fig. 1 shows the equivalent circuit diagram of the 1.6 cell C-band photocathode electron gun. In this figure, L1,C1 are the capacitor and inductor about the 0.6 cell cavity, and L2, C2 are the capacitor and inductor about the 1cell cavity. The natural frequency of the 0.6 cell cavity is f1, and the natural frequency of the 1 cell cavity is f2. | Zong Yang Zhang Zimin Cao Shuchun Shen Xiaokang Zhao Quantang Wang Yanru | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 17 | 6-21 Primary Design of Beam Dynamics on Compact C-band Electron Linear Accelerator for High Energy Electron Radiography显示文摘At the beginning of 2014, the Institute of Modern Physics started to develop the research of high energy electronradiography towards high energy density state/inertial confinement fusion diagnostics. One of the important topicsis the electron linac specification for the high energy density target imaging system. A C-band electron Linac wasselected in order to meet the specific requirement of beam dynamics parameters and achieve a compact design,which is designed to work at the frequency of 5.712 | Wang Yanru Zhang Zimin Cao Shuchun Shen Xiaokang Zhao Quantang Li Zhongpin Liu Ming Jing Yi Zong Yang Zhang Xiaoming | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 18 | 电子加速器中心年度研究报告显示文摘In the year 2018,our group mainly focused on two fields of studies.The first important work is High Energy Electron Radiography(HEER)research.Especially we focused on the Lanzhou HEER experimental platform setup.Another one is the investigation on the high average current electron injector for Phase II of HIAF project and some pre-research schemes are planned. | Zhang Zimin Cao Shuchun Sheng Xiaokang Zhao Quantang Zong Yang Liu Ming Li Zhongping Xiao Rongqing | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 19 | 离子束与等离子体相互作用与高能量密度物理研究新型诊断技术进展显示文摘Plasma as the fourth state of matter widely exists in universe and it is the essential state in the process of Initial Confinement Fusion sciences.Ion beam is a unique tool to understand some special properties of plasma itself form the aspect of kinetic interaction between ion and plasma surrounding.The energy loss of helium ions in a dense plasma relates to the self-heating process in a ICF capsule and the radiation protection by Van Allen Radiation Belt of Earth-self against the solar wind.It is a very interesting topic to carry out the series of experiments applying the ion beam and plasma target together in lab[1,2]. | Cheng Rui Wang Yuyu Zhou Xianming Lei Yu Chen Yanhong Zhao Yongtao Ren Jieru Gao Fei Hu Zhanghu Zhang Zimin Cao Shuchun Du Yingchao Zhao quantang Wang Younian Ma Xinwen Xiao Guoqing | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 20 | 3-18 Research Activities Related to High Energy Density Physics显示文摘High energy density is generally defined as a state with energy content larger than 1011 J/m3,or equivalently with pressure higher than 1 Mbar.High energy density matter widely exists in the universe,like the cores of Jupiter,Sun and Earth,as well as inertial confinement fusion.The creation of high energy density state in the laboratory and the research on its properties are very important in astrophysics,planetary sciences,geophysics,inertial fusion sciences and so on.Related to high energy density physics,we carried out a series of research activities including simulation of the state of warm dense matter at HIAF,ion-plasma interaction,highly charged ions induced nanoscale defect on surface and X-ray emission,as well as developing a new multi-channel pyrometer and high energy electron radiography. | Cheng Rui Wang Yuyu Zhou Xianming Lei Yu Zhao Yongtao Hu Zhanghu Zhang Zimin Cao Shuchun Du Yingchao Zhao quantang Chen Yanhong Wang Younian Ma Xinwen Xiao Guoqing | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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