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| 1 | Understanding the need for pre-injection from permeability measurements: What is the connection?显示文摘Pre-grouting ahead of tunnels has three main functions:to control water inflow into the tunnel,to limit groundwater drawdown above the tunnel,and to make tunnelling progress more predictable since rock mass quality is effectively improved.It helps to avoid settlement damage caused by consolidation of clay deposits beneath built-up areas,since towns tend to be built where terrain is more flat,due to the clay deposits.There are so many instances of settlement damage that the profession needs to take note of the need for high-pressure pre-grouting,to use micro-cements and micro-silica additives.The use of highpressure injection may cause joint jacking,but this is local in extent when the rapid pressure decay away from an injection hole is understood.This effect is variable and depends on the geometrical parameters of the joints.This pressure-decay advantage must not be violated by maintaining high pressure when grout flow from the injection hole has ceased.The latter can cause damage to the grouting already achieved.Simplified methods of estimating mean hydraulic apertures(e)from Lugeon testing are described,and from more sophisticated three-dimensional(3D)permeability measurement.The estimation of the larger mean physical joint apertures(E)is based on the joint roughness coefficient(JRC).Comparison is then made with the empirical aperture-particle size criterion E>4d95,where d95 represents almost the largest cement particle size.Depending on joint set orientations and on the available micro-cements,the decision must be made of which range of pre-injection pressure should be aimed for,using successive reductions of the water-cement ratio w/c.More simple estimation of permeability,also with depth dependence,can be made with the empirical link between a modified rock mass quality Q and permeability,which is termed QH2O.The value of this parameter can be based on core-logging or intunnel face logging.The 3D before-and-after-grouting permeability measurements have been used to justify the quantification of rock mass quality Q-parameter improvement,and the consequent increases in expected P-wave velocity and deformation modulus,for application in dam foundation treatment and its monitoring. | Nick Barton Eda Quadros | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，3： | 5 |
| 2 | Thrombosis in ST-elevation myocardial infarction:Insights from thrombi retrieved by aspiration thrombectomy显示文摘In patients with ST-elevation myocardial infarction, recurrent cardiovascular events still remain the main cause of morbidity and mortality, despite significant improvements in antithrombotic therapy. We sought to review data regarding coronary thrombus analysis provided by studies using manual aspiration thrombectomy(AT), andto discuss how insights from this line of investigation could further improve management of acute coronary disease. Several studies investigated the fresh specimens retrieved by AT using techniques such as traditional morphological evaluation, optical microscopy, scanning electron microscopy, magnetic resonance imaging, and immunohistochemistry. These approaches have provided a better understanding of the composition and dynamics of the human coronary thrombosis process, as well as its relationship with some clinical outcomes. Recent data signaling to new antithrombotic therapeutic targets are still emerging. | Daniel Rios P Ribeiro Eduardo Cambruzzi Marcia Moura Schmidt Alexandre S Quadros | 2016 | World Journal of Cardiology2016，8，6： | 2 |
| 3 | Endothelial function in patients with slow coronary flow and normal coronary angiography 显示文摘 | SIGNORI LU QUADROS AS SBRUZZI G | 2012 | Clinics ( Sao Paulo)2012，67，6： | 1 |
| 4 | Serum bili-rubin concentration in patients with an established coronary arterydisease显示文摘 | Ghem C Sarmento-Leite RE de Quadros AS | 2010 | Int Heart J2010，51，2： | 1 |
| 5 | Measles elimination in the Americas 显示文摘 | De Quadros CA Olive JM Hersh BC | 1996 | J Am Med Assoc1996，275，3： | 1 |
| 6 | Inhibition of Aβ production by NF-κB inhibitors显示文摘 | Paris D Patel N Quadros A | 2007 | Neurosci Lett2007，415，1： | 1 |
| 7 | Understanding the physiological role of retinol-binding protein in vitamin A metabo- lism using transgenic and knockout mouse models显示文摘 | Quadro L Hamberger L Colantuoni V | 2003 | Mol Aspects Med2003，24，6： | 1 |
| 8 | Targeting the epidermal growth factor receptor in cancer:apoptosis takes center stage显示文摘 | Kari C Chan TO Rocha de Quadros M | 2003 | Cancer Res2003，，： | 1 |
| 9 | Basal metabolic rate and body composition in patients with post-polio syndrome显示文摘 | Bargieri JV Quadros AA Pereira RD | 2008 | Ann Nutr Metab2008，53，34： | 1 |
| 10 | Quality of life and health status after percutaneous coronary intervention in stable angina patients显示文摘 | De Quadros AS Lima TC | 2011 | Catherter Cardiovasc Interv2011，77，7： | 1 |
| 11 | EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-δ activities显示文摘 | Quadros MR Connelly S Kari C Abrams MT Wickstrom E Rodeck U | | 0，，05： | 1 |
| 12 | Progress in vaccination against Haemophilus inflaenzae type b in the Americas 显示文摘 | Danovaro-Holliday MC Garcia S de Quadros C | 2008 | PLoS Med2008，5，4： | 1 |
| 13 | Impaired retinal functionand vitamin A availability in mice lacking retinol-binding protein显示文摘 | Quadro L Blaner WS Salchow DJ | 1999 | EMBO J1999，18，17： | 1 |
| 14 | Source,level and age differences in fat utilization in broilers 显示文摘 | Machado L P Vieira S L Quadros R V | 2003 | Poul Sci2003，82，： | 1 |
| 15 | A computational framework for automating generation of sizing function in assembly meshing via disconnected skeletons显示文摘 | QUADROS W R VYAS V BREWER M | 2010 | Engineering with Computers2010，26，3： | 1 |
| 16 | Endovascular treatment of middle cerebral artery aneurysms as first option:a single center experience of 92 aneurysms显示文摘 | Quadros RS Gallas S Noudel R | 2007 | Am J Neuroradio12007，28，： | 1 |
| 17 | Risk of vaccine- associated paralytic poliomyelitis in Latin America, 1989-1991 显示文摘 | Andrus JK Strebel PM de Quadros CA | 1995 | Bull WHO1995，73，1： | 1 |
| 18 | Bacterial translocation:overview of mechanisms and clinical impact显示文摘 | Balzan S de Almeida Quadros C | 2007 | J Gastroenterol Hepatol2007，22，4： | 1 |
| 19 | High-pressure liquid chromatographic evaluation of cyclic paracetamol-acetysalicylate and its active metabolites with results of a comparative pharmacokinetic investigation in the rat显示文摘 | Marzo A Quadro G Treffner E | 1990 | Drugs Res1990，40，7： | 1 |
| 20 | Bacterial translocation:over view of mechanicsms and clinical impact显示文摘 | Balzan S de Almeida Quadros C de Cleva R | 2007 | J Gastroenterol Hepatol2007，22，4： | 1 |
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