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| 1 | Fluxes of CO_2, N_2O and CH_4 from a typical temperate grassland in Inner Mongolia and its daily variation显示文摘Using a dark enclosed chamber technique, the fluxes of CO2, N2O and CH4 from nature and disturbed grassland were measured on the spot in Inner Mongolian Temperate Grassland along the annual rainfall gradient section ranging from 450 to 200 mm. The results showed that the measured mean fluxes of CO2, N2O and CH4were (1 180.4 ±308.7), (0.010 ± 0.004) and (-0.039 ± 0.016) mg · m-2/h, respectively. The decrease of the fluxes of CO2, N2O and CH4 follows with that of annual rainfall gradient in the measurement area. Human activities, such as grazing and reclamation are also critical factors to affect the fluxes of these gases from grassland. Daily continuous measurement of CO2, N2O and CH4 fluxes showed a strong diurnal variation with higher emission in the daytime. A good relationship between the fluxes of CO2, N2O, CH4 and temperature was exposed in this study. | DONG Yunshe, ZHANG Shen, Ql Yuchun, CHEN Zuozhong & GENG Yuanbo1. Institute of Geography, Chinese Academy of Sciences, Beijing 100101, China:2, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China Correspondence should be addressed to Dong Yunshe | 2000 | Chinese Science Bulletin2000，45，17： | 66 |
| 2 | 慢性阻塞性肺疾病加重期间肠道和肺部微生物的动态变化显示文摘肠道-肺微生态系统紊乱和调节障碍在慢性阻塞性肺疾病(COPD)恶化过程中发挥关键性作用然而,COPD急性加重期肠道-肺菌群的动态变化及其在疾病病因学中的潜在作用仍知之甚少。研究者为了解慢性阻塞性肺疾病急性加重期(AECOPD)肠道和肺部微生物的动态变化,在15例AECOPD患者急性发作第1、7天和第4天纵向收集90份标本(痰液和粪便标本各45份)。 | Sun Z Zhu QL Shen Y 曾雪涛(编译) | 2020 | 中华医学杂志2020，100，40： | 23 |
| 3 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 4 | Excited states of coherent state and their nonclassical properties显示文摘QUANTIZED radiation fields exhibiting nonclassical properties have been of great theoretical andexperimental interest in the last two decades. It is shown that various nonclassical states suchas squeezed state and Schrodinger cat state can be generated out of coherent state in thenonlinear process of the interaction of atom and field although the radiation field in a | Wei, LF Wang, SJ Jie, QL | 1997 | Chinese Science Bulletin1997，42，20： | 11 |
| 5 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 6 | 组蛋白甲基转移酶SETD2在肝组织中的缺陷导致脂质代谢异常及肝癌显示文摘【据Hepatology 2021年5月报道】题:组蛋白甲基转移酶SETD2在肝组织中的缺陷导致脂质代谢异常及肝癌(作者Li XJ等)组蛋白甲基转移酶SETD2所催化的H3K36me3是从酵母到哺乳动物都保守的表观遗传修饰之一。SETD2可以抑制肿瘤发生且在多种癌症中频繁发生突变。来自武汉大学生命科学学院免疫与代谢前沿科学中心的Li等利用SETD2肝脏特异性敲除的小鼠模型发现,SETD2缺失可导致自发性肝癌。 | LI XJ LI QL JU LG 吴旻 | 2021 | 临床肝胆病杂志2021，37，6： | 6 |
| 7 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 8 | Nonlinear analytical solution for one-dimensional consolidation of soft soil under cyclic loading显示文摘This paper presents an analytical solution for one-dimensional consolidation of soft soil under some common types of cyclic loading such as trapezoidal cyclic loading, based on the assumptions proposed by Davis and Raymond (1965) that the decrease in permeability is proportional to the decrease in compressibility during the consolidation process of the soil and that the distribution of initial effective stress is constant with depth. It is verified by the existing analytical solutions in special cases. Using the solution obtained, some diagrams are prepared and the relevant consolidation behavior is investigated. | XIE Kang-he Ql Tian DONG Ya-qin | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，8： | 3 |
| 9 | Functions and applications of polypyridyl complexes in DNA显示文摘The syntheses and desymmetration of a series of novel polypyridyl ligands as well as their complexes, and their DNA-binding properties are reported in this review. The stresses are focused on the functions and potential applications of such complexes as DNA structural probe, DNA molecular light switches, anti-cancer drugs, and photoactivated cleavage agents. | Ji, LN Zhang, QL Chao, H | 2001 | Chinese Science Bulletin2001，46，16： | 2 |
| 10 | Synthesis of 3-D ordered macroporous silicate using the template formed from monodispersed polystyrene latex显示文摘Based on the template formed from monodispersed polystyrene (PS) latex, a modified fast sol-gel process was employed to synthesize a three-dimensional ( 3-D ) ordered macroporous silica material after removing the template by calcination at high temperature. It was indicated that there existed highly ordered packed pores within the whole silica material by SEM morphology observation. It was also found that the pores were interconnected. The pore size could be controlled mainly by varying the particle size of the latex ranging from 101 to 102 nm. The formation process of the ordered pores was also preliminarily discussed. | Ql Kai YANG Zhenzhong WANG Lijun LIU Zhengping ZHAO Delu | 2000 | Chinese Science Bulletin2000，45，11： | 2 |
| 11 | Isolated olistoliths from the Lower Triassic Xikou Formation in southwestern Fujian and its geological significance显示文摘ISOLATED olistoliths refer to massive blocks of rock occurring out of place, but with sedimentary contact relationship, within unrelated sediments. They were transported as single masses into the basins in which they occurred. In this note we will first report examples found from the Lower Triassic Xikou Formation in southwestern Fujian and discuss its geological significance. | Li, PJ Hou, QL Li, JL Sun, S | 1997 | Chinese Science Bulletin1997，42，2： | 2 |
| 12 | THE NUMERICAL METHODS FOR SOLVING EULER SYSTEM OF EQUATIONS IN REPRODUCING KERNEL SPACE H^2(R)显示文摘A new method is presented by means of the theory of reproducing kernel space and finite difference method, to calculate Euler system of equations in this paper. The results show that the method has many advantages, such as higher precision, better stability, less amount of calculation than any other methods and the reproducing kernel function has good local properties and its derived function is wavelet function. | Wu, BY Zhang, QL | 2001 | Journal of Computational Mathematics2001，19，3： | 2 |
| 13 | Cleavage of human inhibitor of apoptosis XIAP results in fragments with distinct specificities for caspases 显示文摘 | Deveraux QL Leo E Stennicke HR | 1999 | EMBO J1999，18，19： | 1 |
| 14 | Repression of telomerase reverse transcriptase mRNA and hTERT promoter by inhibitory effects of oncogene C-myc in gambogic acid treated-human gastric carcinoma cells显示文摘 | Guo QL You QD | 2006 | Cancer Chemother Pharmacol2006，58，6： | 1 |
| 15 | Boron influences pollen germination and pollen tube growth in Picea meyeri显示文摘 | Lu LD Wu XQ | 2003 | Tree physiology2003，23，5： | 1 |
| 16 | Spatial variation regularities of cosmic radiation and evaluation of exposure doses to aircrews显示文摘 | Gui SG Fan XM | 1996 | Chin J Radiol Med Prot1996，16，6： | 1 |
| 17 | Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy:a meta-analysis显示文摘 | Liang QL Shi HZ Wang K | 2008 | Respir Med2008，102，5： | 1 |
| 18 | Epidemiology of chronic kidney disease: results from a population of older adults in Germany 显示文摘 | Zhang QL Koenig W Raum E | 2009 | Prey Med2009，48，2： | 1 |
| 19 | Expression of bc1-2in bladder neoplasm-ma is cell lineage associated and P53-independent evnt显示文摘 | LU QL LDAIDO M | 1997 | Mol Pathot1997，50，： | 1 |
| 20 | Differential gene expression of CD34^+ hematopoietic stem and progenitor cells before and after culture 显示文摘 | Li QL Cai HB Tan WS | 2006 | Biotechnol Lett2006，28，6： | 1 |
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