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| 1 | A national report from China Liver Transplant Registry: steroid avoidance after liver transplantation for hepatocellular carcinoma显示文摘Objective:We aimed to evaluate the efficacy and safety of steroid-free immunosuppression after liver transplantation(LT)for hepatocellular carcinoma(HCC).Methods:We retrospectively analyzed HCC recipients without steroids after LT(SF group,n=368)based on the China Liver Transplant Registry(CLTR)database.These recipients were matched 1:2 with patients using steroids(S group,n=736)for the same period after LT for HCC,according to propensity scores.Results:Multivariate analysis indicates that recipients with younger age[odds ratio(OR),1.053;P=0.011],preoperative hepatitis B virus(HBV)DNA≥1,000 copies/mL(OR,2.597;P=0.004)and beyond Milan criteria(OR,4.255;P<0.001)were identified as the risk factors associated with tumor recurrence in steroid avoidance recipients after LT.The patients fulfilling the Milan criteria in the SF group presented higher overall and tumor-free survival rates than those in the S group(P<0.05).Multivariate analysis revealed that recipient beyond Milan criteria was an independent prognostic factor for overall survival(OR,1.690;P<0.001)and tumor-free survival(OR,2.066;P<0.001).The incidences of new-onset diabetes mellitus(21.20% vs.33.29%,P<0.001),new-onset hypertension(10.05%vs.18.61%,P<0.001)and hyperlipidemia(4.08% vs.7.20%,P=0.042)were significantly lower in the SF group.Conclusions:Steroid-free immunosuppression could be safe and feasible for HBV-related HCC patients in LT.Age,HBV DNA level and Milan criteria maybe risk factors associated with tumor recurrence in steroid avoidance recipients.Recipient beyond Milan criteria was an independent prognostic factor and recipient fulfilling Milan criteria can benefit the most from steroid-free immunosuppression. | Qiang Wei Feng Gao Runzhou Zhuang Qi Ling Qinghong Ke Jian Wu Tian Shen Mangli Zhang Min Zhang Xiao Xu Shusen Zheng | 2017 | Chinese Journal of Cancer Research2017，29，5： | 25 |
| 2 | Effect of neoadjuvant chemotherapy on expressions of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and Ki-67 in breast cancer显示文摘 | Qin Qinghong Gao Fangfang Jiang Wei Tan Qixing Mo Qinguo Wei Changyuan | 2014 | Chinese Medical Journal2014，，18： | 13 |
| 3 | Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway显示文摘As an important component of the tumor microenvironment,cancer-associated fibroblasts(CAFs)secrete energy metabolites to supply energy for tumor progression.Abnormal regulation of long noncoding RNAs(lncRNAs)is thought to contribute to glucose metabolism,but the role of lncRNAs in glycolysis in oral CAFs has not been systematically examined.In the present study,by using RNA sequencing and bioinformatics analysis,we analyzed the lncRNA/mRNA profiles of normal fibroblasts(NFs)derived from normal tissues and CAFs derived from patients with oral squamous cell carcinoma(OSCC).LncRNA H19 was identified as a key lncRNA in oral CAFs and was synchronously upregulated in both oral cancer cell lines and CAFs.Using small interfering RNA(siRNA)strategies,we determined that lncRNA H19 knockdown affected proliferation,migration,and glycolysis in oral CAFs.We found that knockdown of lncRNA H19 by siRNA suppressed the MAPK signaling pathway,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3)and miR-675-5p.Furthermore,the lncRNA H19/miR-675-5p/PFKFB3 axis was involved in promoting the glycolysis pathway in oral CAFs,as demonstrated by a luciferase reporter system assay and treatment with a miRNA-specific inhibitor.Our study presents a new way to understand glucose metabolism in oral CAFs,theoretically providing a novel biomarker for OSCC molecular diagnosis and a new target for antitumor therapy. | Jin Yang Xueke Shi Miao Yang Jingjing Luo Qinghong Gao Xiangjian Wang Yang Wu Yuan Tian Fanglong Wu Hongmei Zhou | 2021 | International Journal of Oral Science2021，13，1： | 8 |
| 4 | Recent advances in developing small-molecule inhibitors against SARS-CoV-2显示文摘The COVID-19 pandemic caused by the novel SARS-CoV-2 virus has caused havoc across the entire world.Even though several COVID-19 vaccines are currently in distribution worldwide,with others in the pipeline,treatment modalities lag behind.Accordingly,researchers have been working hard to understand the nature of the virus,its mutant strains,and the pathogenesis of the disease in order to uncover possible drug targets and effective therapeutic agents.As the research continues,we now know the genome structure,epidemiological and clinical features,and pathogenic mechanism of SARS-CoV-2.Here,we summarized the potential therapeutic targets involved in the life cycle of the virus.On the basis of these targets,small-molecule prophylactic and therapeutic agents have been or are being developed for prevention and treatment of SARS-CoV-2 infection. | Rong Xiang Zhengsen Yu Yang Wang Lili Wang Shanshan Huo Yanbai Li Ruiying Liang Qinghong Hao Tianlei Ying Yaning Gao Fei Yu Shibo Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 5 | Inferring user profiles in social media by joint modeling of text and networks显示文摘Dear editor,With the rapid growth of social media platforms such as Twit ter and Chinese Weibo,personalized services,such as recommendation and personalized advertising,provide more engaging experiences for the users.A prerequisite to personalized services is effective user profiling.However,many users do not want to share their profiles online due to the privacy concerns.To address this problem,automatic user profiling based on users5 posted contents and their social activities online has attracted many attentions in recent years[1-3]. | Ruifeng XU Jiachen DU Zhishan ZHAO Yulan HE Qinghong GAO Lin GUI | 2019 | Science China(Information Sciences)2019，62，11： | 3 |
| 6 | One-step preparation of size-defined aggregates of Ti02 nanocrystals with tuning of their phase andcomposition 显示文摘 | Zhang Qinghong Gao Lian | 2006 | Journal of the European Ceramic Society2006，26，： | 1 |
| 7 | Preparation of long TiO2 nanotubes from ultrafine rutile nanocrystals显示文摘 | Zhang Qinghong Gao Lian Sun Jing | 2002 | Chemistry Letter2002，31，2： | 1 |
| 8 | Effects of calcinations on the photocatalytic properties of nanosized TiO2 powders prepared by TiCl4 hydrolysis显示文摘 | ZHANG Qinghong GAO Lian GUO Jingkun | 2000 | Applied Catalysis B:Environmental2000，26，： | 1 |
| 9 | Preparation Of oxide nanocrystals with tunable morphologies by the moderate hydro-thermal method: insights from rutile TiO2显示文摘 | ZHANG Qinghong GAO Lian | 2003 | Langmuir2003，19，3： | 1 |
| 10 | Effect of hydrolysis conditions on morphology and crystallization of nanosized TiO2 powder显示文摘 | ZHANG Qinghong GAO Lian GUO Jingkun | 2000 | Journal of the European Ceramic Society2000，20，： | 1 |
| 11 | Effects of calcination on the photoeatalytic properties of nanosized TiO2 powders prepared by TiCl4 hydrolysis 显示文摘 | QINGHONG ZHANG LIAN GAO JINGKUN GUO | 2000 | Applied Catalysis B2000，26，： | 1 |
| 12 | Singlewalled carbon nanotubes coated with titania nanoparticles 显示文摘 | Jing Sun Mikio lwasa Lian Gao Qinghong Zhang | 2004 | Carbon2004，42，4： | 1 |
| 13 | 显示文摘 | Zhang Rubing Gao Lian Zhang qinghong | 2004 | Chemosphere2004，54，： | 1 |
| 14 | 显示文摘 | Zhang Qinghong | 2001 | Scripta Mater2001，44，： | 1 |
| 15 | Preparation of oxide nano crystals with tunable morphologies by the moderate hy drothermal method: insights from futile TiO2显示文摘 | Zhang Qinghong Gao Lian | 2003 | Lang muir2003，19，96： | 1 |
| 16 | 显示文摘 | Zheng Shan Gao Lian Zhang Qinghong Guo Jingkun | 2000 | J Mater Chem2000，10，4： | 1 |
| 17 | TiO2 tubes synthsized by using ammonium sulfate and carbon nanotubes as templates显示文摘 | Sun Jin Gao Lian Zhang Qinghong | 2003 | Materials Science Letters2003，22，： | 1 |
| 18 | 显示文摘 | Zhang Qinghong Gao Lian Guo Jingkun | 2000 | Journal of the European Ceramic Society2000，，20： | 1 |
| 19 | Preparation of long TiO2 nanotubes from ultrafine rutile nanocrystals显示文摘 | Zhang Qinghong Gao Lian Sum Jing | 2002 | Chem Lett2002，31，2： | 1 |
| 20 | Effects of calcination on the photocatalytic properties of nanosized TiO2 powders prepared by TiCl4 hydrolysis显示文摘 | ZHANG Qinghong GAO Lian | 2000 | Appl Catal B Environ2000，26，： | 1 |
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