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| 1 | Geochemical evidence for submarine hydrothermal origin of the Middle-Upper Permian chert in Laibin of Guangxi, China显示文摘Lithologically, two kinds of chert can be recognized in the Middle-Upper Permian from the Tieqiao section in Laibin area, Guangxi, i.e., calcic chert occurring mainly in the Maokou Formation and pure chert mainly in the Wujiaping Formation. Geo- chemical data show that both kinds of chert contain very low Al2O3 (0-0.23%) and TiO2 (0.001%-0.024%) and low ΣREE (0.55-19.94 ppm, averaging 9.97 ppm), as well as high ratio of Fe2O3/TiO2 (17-443, averaging 111) and low ratio of Al2O3/(Al2O3+Fe2O3) (0-0.26, averaging 0.09). Given that the average value Ce anomalies in chert deposited in the ridge-proximal environment is about 0.29, and that in the pelagic environment is about 0.60, the low Ce anomalies in the Tieqiao chert (0.24-0.46, averaging 0.35) imply that they were deposited in an ocean basin with influence of submarine hydrothermal fluid and no input of terrigenous materials. The vertical variation of the silica abundance in strata (SAIS) in the Middle-Upper Permian strata, together with the Eu anomalies and the ratios of ΣREE/Fe, indicates a relationship between the hydrothermal activity and the Emeishan basalt eruption, and that submarine hydrothermal activity was stronger in the Upper Permian (the Wujiapingian Stage) than in the Middle Permian (the Maokou Stage). | QIU Zhen WANG QingChen | 2011 | Science China Earth Sciences2011，54，7： | 25 |
| 2 | Late Mesozoic extensional tectonics of the Liaodong Peninsula massif:Response of crust to continental lithosphere destruction of the North China Craton显示文摘Unlike most Precambrian cratons that have thick sub-continental lithospheric roots,the Archean lithosphere beneath the North China Craton is thin (reduced from 200 km to about 80 km),and has been replaced by a geochemically juvenile lithospheric mantle.This is a unique regional geological event,which has attracted worldwide attention.In the North China Block,Late Mesozoic extensional tectonics is evident by low-angle detachment faults,syntectonic plutons bounded by ductile faults,metamorphic core complexes (MCC) and widespread Jurassic to Cretaceous half-grabens filled by continental terrigenous deposits and volcanic rocks.At a regional scale,these structures share the same NW-SE extensional direction,while maintaining their own individual kinematics.In other words,the MCC feature a top-to-the-NW sense of shear,and syntectonic plutons are typified by a top-to-the-SE shearing deformations.Geochronological results indicate that the extensional structures were formed between 130-120 Ma.These extensional events lead to magmatic rock emplacement,distributed at the footwall of the detachment faults.Two different exhumation stages can be identified based on regional structural and magmatic interpretation:a Jurassic slow or negligible exhumation and a Cretaceous fast one assisted by normal faulting.These two cooling stages correspond to distinct geodynamic processes that occurred during the Jurassic and Cretaceous.Extensional tectonics appear to have been insignificant before the Early Cretaceous,and the process may be demonstrated by partial melting of the crust.The second stage,dominated by an extensional regime,developed after ca 120 Ma,and is tentatively correlated with crustal extension caused by lithospheric removal of the North China Craton. | LIN Wei WANG QingChen WANG Jun WANG Fei CHU Yang CHEN Ke | 2011 | Science China Earth Sciences2011，54，6： | 24 |
| 3 | The Dabie-Sulu UHP rocks belt:review and prospect显示文摘The new results in the studies of the Dabie-Sulu UHP rocks belt during the past 5 years were summarized and discussed. The discussion included the following key points: ( i ) UHP eclogite has two kinds of country rocks, with one being UHP eclogite facies rocks and the other non-UHP granitic gneiss. ( ii ) The FeTiO3 in olivine indicated exsolution at depth of 300-400 km. However, the key point is to prove the peridotite in which the FeTiO3 in olivine was found once had been subducted down that depth. (iii ) UHP hydrous phase evidenced that fluids had taken part in the UHP metamorphism, while the meter-scale inhomogeneous distribution of O-, C-isotope indicated no fluid activity in the deep subduction environment. (iv ) No agreement has been arrived on many problems related to the tectonic background of the UHP rocks, such as 'whether or not ophiolitic rocks there exist now?', 'when did UHP metamorphism proceed?', 'what is the subdution polarity?', etc. ( V ) How did the UHP rocks exhume from mantle | Bolin Cong Qingchen Wang | 1999 | Chinese Science Bulletin1999，44，12： | 21 |
| 4 | Geochemical changes across the Ordovician-Silurian transition on the Yangtze Platform,South China显示文摘The trace element and rare earth element(REE) variations across the Ordovician-Silurian succession are presented from two outcrop sections on the Yangtze Platform:the Nanbazi section,Guizhou Province,deposited in a shallow platform interior setting,and the Wangjiawan section,Hubei Province,deposited in a deeper basinal environment.Geochemical analysis of closely spaced samples through three intervals,the Wufeng,Guanyinqiao and Longmaxi,revealed vast palaeoceanographic changes.Some geochemical proxies,including Th/U,Ni/Co,V/Cr,and V/(V+Ni) ratios,together with sedimentary facies and biotic data,indicate that an anoxic condition on the most of the Yangtze Platform during the Wufeng and Longmaxi intervals,but an oxic condition during the Guanyinqiao time.The shift of the anoxic to the oxic environment during the Guanyinqiao time coincided with a global sea-level lowstand,in parallel with the global glaciation.The Longmaxian anoxic environment was a result of a global sea-level rise,which may be synchronized with a mainly catastrophic event in the latest Ordovician.Although the two sections generally show similar variation patterns of trace and REE concentrations and some element ratios,a minor difference occurs between the Wangjiawan and Nanbazi sections,likely reflecting a difference in depositional setting during the accumulation.Such an oceanic oxygen-level variation may add a useful constraint to the current arguments on the cause and consequence of the latest Ordovician mass extinction. | YAN DeTian CHEN DaiZhao WANG QingChen WANG JianGuo | 2009 | Science China Earth Sciences2009，52，1： | 17 |
| 5 | Tectonic Framework and Deep Structure of South China and Their Constraint to Oil-Gas Field Distribution显示文摘华南能在包围区域被划分成一稳定的 craton , Yangtze Craton ( YzC ),和几条 orogenic 带,那在北方是三叠纪的 Qinling-Dabie Orogenic 带( QDOB ),在西北的 Songpan-Garz ê Orogenic 带( SGOB ),在西方,在西南的 Youjiang Orogenic 带(出生年),在东南的中间的古生代的 Huanan Orogenic 带(壁炉内部的一锅架),和沿着海岸的中生代新生代海上的 Orogenic 带(乌合之众)的中生代新生代三河的 Orogenic 带( TOB )。地震 tomographic 图象表明莫霍深度比 40 km 深,岩石圈是在 YzC 下面厚的大约 210 km。SGOB 被厚外壳(>40 km ) 和薄岩石圈(<150 km ) 描绘。壁炉内部的一锅架,出生年和乌合之众有一个薄外壳(<40 km ) 和薄岩石圈(<150 km ) 。陆上的热流动调查分别地在 TOB 和乌合之众在东方 YzC 和西方的壁炉内部的一锅架和二个高热流动区域与一个低热流动区域揭示了一个分发模式。如此的“ high-low-high ”热流动分发模式能在 welling 上面源于新生代岩流圈。所有油气体地在 YzC 的中央部分被集中。残余油水池沿着 YzC 和它的邻近的 orogenic 带的南部的边缘被发现了。从地质、地球物理的结构,在有厚岩石圈和低热流动价值的华南的区域,以及弱变丑的一个观点,可能是为进一步的石油探索的理想的区域。 | WANG Qingchen LIU Jinsong DU Zhili CAI Liguo | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 16 |
| 6 | High-Q resonances governed by the quasi-bound states in the continuum in all-dielectric metasurfaces显示文摘The realization of high-Q resonances in a silicon metasurface with various broken-symmetry blocks is reported. Theoretical analysis reveals that the sharp resonances in the metasurfaces originate from symmetry-protected bound in the continuum(BIC) and the magnetic dipole dominates these peculiar states. A smaller size of the defect in the broken-symmetry block gives rise to the resonance with a larger Q factor. Importantly, this relationship can be tuned by changing the structural parameter, resulting from the modulation of the topological configuration of BICs. Consequently, a Q factor of more than 3,000 can be easily achieved by optimizing dimensions of the nanostructure. At this sharp resonance, the intensity of the third harmonic generation signal in the patterned structure can be 368 times larger than that of the flat silicon film. The proposed strategy and underlying theory can open up new avenues to realize ultrasharp resonances, which may promote the development of the potential meta-devices for nonlinearity, lasing action, and sensing. | Cizhe Fang Qiyu Yang Qingchen Yuan Xuetao Gan Jianlin Zhao Yao Shao Yan Liu Genquan Han Yue Hao | 2021 | Opto-Electronic Advances2021，4，6： | 8 |
| 7 | Seismic tomography showing subduction and slab breakoff of the Yangtze block beneath the Dabie-Sulu orogenic belt显示文摘Seismic tomography reveals that a subducted ancient block has been preserved beneath the Moho of the Dabie-Sulu orogenic belt. Taking into account of geological and geochronological data, we inferred from the tomographic images that the Yangtze block was subducted northward beneath the Sino-Korean block and broken off at the depth <200 km during 200-190 Ma. The slab breakoff of the Yangtze block is the most important dynamic mechanism to control the exhumation of UHP rocks. | Peifen Xu Ruomei Sun Futian Liu Qingchen Wang Bolin Cong | 2000 | Chinese Science Bulletin2000，45，1： | 7 |
| 8 | Development of joints and shear fractures in the Kuqa depression and its implication to regional stress field switching显示文摘The superimposed basin must have undergone the changes of regional stress field. Study on the nature and switch of regional stress field of superimposed basin is very useful to understanding its stress state and tectonic events during its formation and evolution. As sensitive markers of small stress changes, joint and shear fracture, characterized by consistency of ori-entation over wide area, can be used to reconstruct paleostress state and its evolution. Detailed observations and analysis on the orientations, geometrical patterns, sequences of joints and shear fractures and their chronological relation to faults and folds show that, the NEE-SWW systematic joints and NNW-SSE systematic joints developed in the Mesozoic and Cenozoic strata are much more prominent than NW-SE systematic joints and shear fractures with different orientations. And the NWW-SEE and NW-SE systematic joints formed later than NEE-SWW systematic joints but earlier than shear fractures with different orientations. According to the rela-tionships between joint and shear fractures and stress, the NEE-SWW systematic joints are in-ferred to result from lateral weak extension caused by the late Cretaceous regional uplift, while the NNW-SSE and NW-SE systematic joints are interpreted as syn-tectonic deformation relating to strong N-S compression in the Neogene. But some conjugate shear fractures occur probably due to sinistral strike-slip faulting in the Kuqa depression. At the beginning of the Neogene, the stress field changed and the maximal principal stress s1 switched from vertical to horizontal. | ZHANG Zhongpei WANG Qingchen | 2004 | Science China Earth Sciences2004，47，z2： | 7 |
| 9 | First imaging observation of the gravity waves in the mesopause region in China显示文摘The first imaging observation experiment of the atmospheric gravity waves in the mesopause region with the all-sky OH Meinel band airglow CCD imager is made during 02:00 to 06:00 on January 5,2009,at Hancun (39.4°N,116.6°E),Langfang,Hebei in China.Quasi-monochromatic gravity waves (QMGWs) are found clearly in the observation data.Case studies show that their horizontal wavelengths,horizontal phase velocities,azimuth angles of horizontal propagation directions and periods of three QMGW examples are about 12.3 km,41 m/s,327°,5 min;25 km,35 m/s,68°,12 min;and 10 km,48 m/s,341°,3.5 min respectively. | TU Cui HU Xiong YAN ZhaoAi XU QingChen ZHAO MingLiang LIU Jia | 2010 | Chinese Science Bulletin2010，55，6： | 7 |
| 10 | Responses of zonal wind at -40°N to stratospheric sudden warming events in the stratosphere, mesosphere and lower thermosphere显示文摘Based on the data at^40°N at different longitudes during different stratospheric sudden warming(SSW)events,the responses of zonal winds in the stratosphere,mesosphere and lower thermosphere to SSWs are studied in this paper.The variations of zonal wind over Langfang,China(39.4°N,116.7°E)by MF radar and the modern era retrospective-analysis for research and applications(MERRA)wind data during 2010 and 2013 SSW and over Fort Collins,USA(41°N,105°W)by lidar and MERRA wind data during 2009 SSW are compared.Results show that the zonal wind at^40°N indeed respond to the SSWs while different specifics are found in different SSW events or at different locations.The zonal wind has significant anomalies during the SSWs.Over Langfang,before the onset of 2010 and 2013 SSW,the zonal wind reverses from eastward to westward below about 60–70 km and accelerates above this region,while westward wind prevails from 30 to 100 km after the onset of2010 SSW,and westward wind prevails in 30–60 and 85–100 km and eastward wind prevails in 60–85 km after the onset of2013 SSW.Over Fort Collins during 2009 SSW,eastward wind reverses to westward in 20–30 km before the onset while westward wind prevails in 20–30 and 60–97 km and eastward wind prevails in 30–60 and in 97–100 km after the onset.Moreover,simulations by the specified dynamics version of the whole atmosphere community climate model(SD-WACCM)are taken to explain different responding specifics of zonal wind to SSW events.It is found that the modulation of planetary wave(PW)plays the main role.Different phases of PWs would lead to the different zonal wind along with longitudes and the different amplitudes and phases in different SSW events can lead to the different zonal wind responses. | YANG JunFeng XIAO CunYing HU Xiong XU QingChen | 2017 | Science China(Technological Sciences)2017，60，6： | 5 |
| 11 | Rutile U-Pb age for the ultra-high pressure eclogite from the Dabie Mountains, central China: Evidence for rapid cooling显示文摘The U-Pb isotope compositions of rutile, om-phacite and garnet in the eclogite from the Jinheqiao area in the Southern Dabie ultrahigh-pressure metamorphic zonewere analyzed. The consistent high precision U-Pb age (218± 1.2) Ma of rutile in eclogite from the Dabie Mountains was obtained by two ways of isochron and common Pb correction based on the composition of omphacite. This proves that the omphacite in eclogite has a U/Pb ratio (μ = 2.8) low enough to be used for common Pb correction in the analyses of rutile. Under the rapid cooling condition (40℃/Ma) the closure temperature for U-Pb diffusion in rutile is about 470℃. Thus, this U-Pb age of rutile proves that 218 Ma should be the cooling age of eclogite at 470℃ instead of the peak meta-morphic age. | LI Qiuli LI Shuguang ZHOU Hongying LI Huimin HONG Ji’an WANG Qingchen H.J.Massonne | 2002 | Chinese Science Bulletin2002，47，1： | 5 |
| 12 | Magnetostratigraphic study of Cretaceous depositional succession in the northern Kuqa Depression,Northwest China显示文摘There are some quite different disputes about chronostratigraphic division of the Cretaceous in the Kuqa Depression, northern margin of the Tarim Basin. We then carried on a magnetostratigraphic study on Cretaceous succession in the Kuqa River and Kezilenuer Channel profiles. Detailed paleomag- netic analyses on 446 specimens from 265 sites permit a construction of a preliminary magnetic polar- ity sequence for the Cretaceous strata. Together with paleobiologic constraints from calcareous nannofos- sils, magnetostratigraphic results show that the Bash- enjiqike Formation was probably deposited during the late Campanian to Maastrichtian stages of the Late Cretaceous, ranging from about 79.1 to 65.6 Ma. On the other hand, magnetozones identified from the Yageliemu, Shushanhe, and Baxigai formations may principally correlate with chrons M18r to M3 of the Geomagnetic Polarity Time Scale (GPTS). This cor- relation suggests that these three formations were very likely to be formed during the early-middle stage of the Early Cretaceous between the Berriasian to the early Berremian stages (141.9―124.1Ma). Therefore it is possible that the Bashenjiqike Formation con- tacts the underlying strata with an unconformity and there is a giant sedimentary hiatus during the period of the late Barremian to early Maastrichtian stages in the Kuqa Depression. | PENG Shoutao LI Zhong HUANG Baochun LIU Tao WANG Qingchen | 2006 | Chinese Science Bulletin2006，51，1： | 5 |
| 13 | A Versatile Crosslinking Strategy on Facile Fabrication of Fluorescent Hydrogels via o-Phthalaldehyde Ternary Condensation显示文摘It is of great sighificance to develop rapid crosslinking strategies to enrich the functions of hydrogels and simplify the preparation process of hydrogels.Herein,we applied the ternary condensation reaction of o-phthalaldehyde(OPA)with thiol and amino moieties to con struct hydrogel n etworks with fast gelati on rate,excellent mecha nical stre ngth,and favorable stability. | Qingchen Cao Hufei Wang Xing Wang Decheng Wu | 2021 | Chinese Journal of Chemistry2021，39，8： | 4 |
| 14 | Building Osteogenic Microenvironments with a Double-Network Composite Hydrogel for Bone Repair显示文摘The critical factor determining the in vivo effect of bone repair materials is the microenvironment,which greatly depends on their abilities to promote vascularization and bone formation.However,implant materials are far from ideal candidates for guiding bone regeneration due to their deficient angiogenic and osteogenic microenvironments.Herein,a double-network composite hydrogel combining vascular endothelial growth factor(VEGF)-mimetic peptide with hydroxyapatite(HA)precursor was developed to build an osteogenic microenvironment for bone repair.The hydrogel was prepared by mixing acrylatedβ-cyclodextrins and octacalcium phosphate(OCP),an HA precursor,with gelatin solution,followed by ultraviolet photo-crosslinking.To improve the angiogenic potential of the hydrogel,QK,a VEGF-mimicking peptide,was loaded in acrylatedβ-cyclodextrins.The QK-loaded hydrogel promoted tube formation of human umbilical vein endothelial cells and upregulated the expression of angiogenesis-related genes,such as Flt1,Kdr,and VEGF,in bone marrow mesenchymal stem cells.Moreover,QK could recruit bone marrow mesenchymal stem cells.Furthermore,OCP in the composite hydrogel could be transformed into HA and release calcium ions facilitating bone regeneration.The double-network composite hydrogel integrated QK and OCP showed obvious osteoinductive activity.The results of animal experiments showed that the composite hydrogel enhanced bone regeneration in skull defects of rats,due to perfect synergistic effects of QK and OCP on vascularized bone regeneration.In summary,improving the angiogenic and osteogenic microenvironments by our double-network composite hydrogel shows promising prospects for bone repair. | Jiaying Li Jinjin Ma Qian Feng En Xie Qingchen Meng Wenmiao Shu Junxi Wu Liming Bian Fengxuan Han Bin Li | 2023 | Research2023，，3： | 3 |
| 15 | Environmental Redox Changes of the Ancient Sea in the Yangtze Area during the Ordo-Silurian Transition显示文摘摘要:广泛有机物(OM ) 富有的外形(黑页岩) 在 Yangtze 区域发生在 Ordo 志留纪边界继任,华南。为了在 Ordo 志留纪期间调查 Yangtze 海的氧化还原作用变化,转移,二 OM 节(在在 Zhangjiajie 的 Yichang,湖北省,和 Sanjiaguan 的 Wangjiawan,湖南省) 跨骑 Ordo 志留纪边界被学习。在这研究完成的大小包括总数的内容 Fe 的器官的碳( TOC ),黄铁矿硫,和不同种类,包括dithionite可引出的 Fe (喂),黄铁矿 Fe ( FeP ),HCI可引出的 Fe ( FeH ),和全部的 Fe ( FeT )在黑页岩,象另外的氧化还原作用代理一样,例如 S/C 比率,在高度反应的 Fe 之间的比率( FeHR =喂了+ FeP )并且 FeT ,和Fep/(FeP + FeH )比率,作为 pyritization ( DOP )的度知道。在 Wangjiawan 节,中间的 Ashgill 沉积有高 FeHR/FeT 比率(0.20-0.77;avg。0.45 ) ,高 DOP 价值(0.21-0.72;avg。0.54 ) ,并且器官的碳内容的一个相对经常的硫内容独立人士。由对比,中间早, Hirnantian 存款通常有低 FeHR/FeT 比率(0.10-0.35;avg。0.21 ) ,低 DOP 价值(0.11-0.40;avg。0.28 ) ,并且 S/C 价值在正常海洋的价值上正在聚类(S/C = 0.36 ) 。迟了的 Hirnantian 和早 Rhuddanian 存款,类似于那些中间的 Ashgill 存款,被高 FeHR/FeT 比率描绘(0.32-0.49;avg。0.41 ) ,高 DOP 价值(0.46-0.68;avg。0.53 ) 并且相当经常的硫内容。这些数据在间隔期间在 Yangtze 海架上建议海洋的血缺氧的出现中间的 Ashgill,迟了的 Hirnantian 和早 Rhuddanian,和通气并且氧化的水兵调节在期间中间早 Hirnantian 时间。中间早, Hirnantian 通气了事件是有全球冰川的经期的伴随物,多半在架海床之上源于 glacio 海面升降的海平面的秋天和冷、稠密的氧化的水的随后的循环。因此,突然的变化从从迟了的 Hirnantian 氧化了到缺氧的海洋的水,早 Rhuddanian 从海面升降的海水平的冰期后的上升被结果。在 subemergent 高地附近从 Sanjiaguan 节与数据结合了,水列的咸度层化被很低的 S/C 比率强烈证实(0.00-0.08, avg。0.02 ) ,低 FeHR/FeT 比率(0.10-0.37, avg。0.27 ) ,低 DOP 价值(0.01-0.27, avg。0.10 ) ,并且 TOC 内容(0.72%-4.27% , avg。2.55%) 。在这种情形下面,缺氧的水列能在 halocline,脱盐的水在上面形成了下面形成了。在 Wangjiawan 节, TOC 内容通常高(0.94-9.32% , avg。4.44%) ,但是低(0.35%-2.12% , avg。1.29%) 在里面中间早,与海洋的 oxic 阶段是重合的和到 stratal 厚度的器官的内容的关系,建议有机物的累积被氧主要控制的 Hirnantian 水列铺平;在另一方面,生产率和 depositional 率可能也在器官的累积和保藏起了一个作用。 | YAN Detian CHEN Daizhao WANG Qingchen WANG Jianguo CHU Yang | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 3 |
| 16 | Arabidopsis EXO70A1 recruits Patellin3 to the cell membrane independent of its role as an exocyst subunit显示文摘The exocyst is a well-known complex which tethers vesicles at the cell membrane before fusion. Whether an individual subunit can execute a unique function is largely unknown. Using yeast-two-hybrid(Y2H) analysis, we found that EXO70A1 interacted with the GOLD domain of Patellin3(PATL3). The direct EXO70A1-PATL3 interaction was supported by in vitro and in vivo experiments. In Arabidopsis, PATL3-GFP colocalized with EXO70A1 predominantly at the cell membrane, and PATL3 localization was insensitive to BFA and Try A23. Remarkably, in the exo70 a1 mutant, PATL3 proteins accumulated as punctate structures within the cytosol, which did not colocalize with several endomembrane compartment markers, and was insensitive to BFA. Furthermore, PATL3 localization was not changed in the exo70 e2, PRsec6 or exo84b mutants. These data suggested that EXO70A1, but not other exocyst subunits, was responsible for PATL3 localization,which is independent of its role in secretory/recycling vesicletethering/fusion. Both EXO70A1 and PATL3 were shown to bind PI4 P and PI(4,5)P2 in vitro. Evidence was obtained that the other four members of the PATL family bound to EXO70A1 as well, and shared a similar localization pattern as PATL3.These findings offered new insights into exocyst subunitspecific function, and provided data and tools for further characterization of PATL family proteins. | Chengyun Wu Lu Tan Max van Hooren Xiaoyun Tan Feng Liu Yan Li Yanxue Zhao Bingxuan Li Qingchen Rui Teun Munnik Yiqun Bao | 2017 | Journal of Integrative Plant Biology2017，59，12： | 3 |
| 17 | Ectopic expression of BdCIPK31 confers enhanced low-temperature tolerance in transgenic tobacco plants显示文摘Calcineurin 象 B 一样蛋白质(CBL ) , Ca 2+ 传感器,和它的交往的蛋白质 kinases (CIPK ) 在植物反应起必要作用强调。然而,很少研究在低温度的反应集中了于 CIPK 的功能。在现在的学习, BdCIPK31,在 Brachypodium distachyon 的寒冷应答的 CIPK,被发现参予低温度的反应。BdCIPK31 的宫外的表示在转基因的烟草授与冷忍耐。进一步的分析显示 BdCIPK31 的那个表达式在低温度的处理下面在转基因的植物改进了 ROS 解毒和 omsoprotectant 生合成,建议 BdCIPK31 在到导致寒冷的氧化、渗透的压力的植物改编断然工作。而且, BdCIPK31 能 upregulate 在寒冷下面的一些代表性的压力相关的基因的表情强调。在结论,这些调查结果建议 BdCIPK31 在植物寒冷反应断然工作。 | Qingchen Luo Qiuhui Wei Ruibin Wang Yang Zhang Fan Zhang Yuan He Guangxiao Yang Guangyuan He | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 3 |
| 18 | TGF-β1-supplemented decellularized annulus fibrosus matrix hydrogels promote annulus fibrosus repair显示文摘Annulus fibrosus(AF)repair remains a challenge because of its limited self-healing ability.Endogenous repair strategies combining scaffolds and growth factors show great promise in AF repair.Although the unique and beneficial characteristics of decellularized extracellular matrix(ECM)in tissue repair have been demonstrated,the poor mechanical property of ECM hydrogels largely hinders their applications in tissue regeneration.In the present study,we combined polyethylene glycol diacrylate(PEGDA)and decellularized annulus fibrosus matrix(DAFM)to develop an injectable,photocurable hydrogel for AF repair.We found that the addition of PEGDA markedly improved the mechanical strength of DAFM hydrogels while maintaining their porous structure.Transforming growth factor-β1(TGF-β1)was further incorporated into PEGDA/DAFM hydrogels,and it could be continuously released from the hydrogel.The in vitro experiments showed that TGF-β1 facilitated the migration of AF cells.Furthermore,PEGDA/DAFM/TGF-β1 hydrogels supported the adhesion,proliferation,and increased ECM production of AF cells.In vivo repair performance of the hydrogels was assessed using a rat AF defect model.The results showed that the implantation of PEGDA/DAFM/TGF-β1 hydrogels effectively sealed the AF defect,prevented nucleus pulposus atrophy,retained disc height,and partially restored the biomechanical properties of disc.In addition,the implanted hydrogel was infiltrated by cells resembling AF cells and well integrated with adjacent AF tissue.In summary,findings from this study indicate that TGF-β1-supplemented DAFM hydrogels hold promise for AF repair. | Qiang Wei Dachuan Liu Genglei Chu Qifan Yu Zhao Liu Jiaying Li Qingchen Meng Weishan Wang Fengxuan Han Bin Li | 2023 | Bioactive Materials2023，，1： | 3 |
| 19 | Wind Tunnel and CFD Study on Identification of Flutter Derivatives of a Long‐Span Self‐Anchored Suspension Bridge显示文摘 | Zhi‐wenZhu MingGu Zheng‐qingChen | 2008 | Computer‐Aided Civil and Infrastructure Engineering2008，，8： | 2 |
| 20 | Single-cell atlas reveals a distinct immune profile fostered by T cell-B cell crosstalk in triple negative breast cancer显示文摘Background:Characterizing the unique immune microenvironment of each tumor is of great importance for better predicting prognosis and guiding cancer immunotherapy.However,the unique features of the immune microenvironment of triple negative breast cancer(TNBC)compared with other subtypes of breast cancer remain elusive.Therefore,we aimed to depict and compare the immune landscape among TNBC,human epidermal growth factor receptor 2-positive(HER2^(+))breast cancer,and luminal-like breast cancer.Methods:Single-cell RNA sequencing(scRNA-seq)was performed on CD45^(+)immune cells isolated from human normal breast tissues and primary breast tumors of various subtypes.By analyzing the scRNA-seq data,immune cell clusters were identified and their proportions as well as transcriptome features were compared among TNBC,human HER2^(+)breast cancer,and luminal-like breast cancer.Pseudotime and cell-cell communication analyses were also conducted to characterize the immune microenvironment.Results:ScRNA-seq data of 117,958 immune cells were obtained and 31 immune clusters were identified.A unique immunosuppressive microenvironment in TNBC was decoded as compared to that in HER2^(+)or luminal-like breast cancer,which was characterized by higher proportions of regulatory T cells(Tregs)and exhausted CD8+T cells and accompanied by more abundant plasma cells.Tregs and exhausted CD8+T cells in TNBC exhibited increased immunosuppression signature and dysfunctional scores.Pseudotime analyses showed that B cells tended to differentiate to plasma cells in TNBC.Cell-cell communication analyses indicated that these unique features are fostered by the diversified T cell-B cell crosstalk in TNBC.Based on the T cell-B cell crosstalk,a prognostic signaturewas established that could effectively predict the prognosis status for patients with TNBC.Additionally,it was found that TNBC had a higher proportion of cytotoxic natural killer(NK)cells,whereas HER2^(+)or luminal-like breast cancer lost this feature,suggesting thatHER2^(+)or luminal-like breast cancer,but not TNBC,may benefit from NK-based immunotherapy.Conclusions:This study identified a distinct immune feature fostered by T cell-B cell crosstalk in TNBC,which provides better prognostic information and effective therapeutic targets for breast cancer. | Shuning Ding Niu Qiao Qingchen Zhu Yiwei Tong Shengyue Wang Xiaosong Chen Qiang Tian Yichuan Xiao Kunwei Shen | 2023 | Cancer Communications2023，43，6： | 2 |
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