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| 1 | HiQoS:An SDN-Based Multipath QoS Solution显示文摘Today's Internet architecture provides only 'best effort' services,thus it cannot guarantee quality of service(QoS) for applications.Software Defined Network(SDN)is a new approach to computer networking that separates control plane and forwarding planes,and has the advantage of centralized control and programmability.In this paper,we propose HiQoS that provides QoS guarantees using SDN.Moreover,HiQoS makes use of multiple paths between source and destination and queuing mechanisms to guarantee QoS for different types of traffic.Experimental results show that our HiQoS scheme can reduce delay and increase throughput to guarantee QoS.Very importantly,HiQoS recovers from link failure very quickly by rerouting traffic from failed path to other available path. | YAN Jinyao ZHANG Hailong SHUAI Qianjun LIU Bo GUO Xiao | 2015 | China Communications2015，12，5： | 19 |
| 2 | Dynamic analysis of urban spatial expansion and its determinants in Xiamen Island显示文摘大多数世界城市在沿海的区域被集中。作为沿海的系统的一个特殊地理部件,岛城市的空间扩大是在城市开发和物理环境之间的相互作用的结果。这篇论文拿厦门岛,在东南的中国定位了,,分析岛的一个例子由在城市的发展政策,城市的全面计划,人口生长和工业开发上联合文学的分析的城市的空间扩大和它的决定因素,与用历史的地图和遥感相片的地理信息分析。第一,我们在最后 100 年期间考察了厦门城市发展的历史,它能被划分成四个时期:从 1908 ~ 1949 的胚胎的现代城市和早开发;从 1950 ~ 1979 的行政边界扩大和基础结构开发;从 1980 ~ 2003 的特殊经济地区建设和快速的都市化;并且海湾城市建设自从 2003。海岸线的动态变化,岛形状,布满建筑物区域,交通,行政部门,和主要陆地使用打发生了在期间的变换近似,过去的 100 年被分析并且岛的特征城市的空间扩大被结束:从一个中央点的早扩大,从海岸线内陆沿着海岸线,和扩大的节由扩大列在后面。第二,我们讨论了岛的潜在的决定因素包括行政部门调整,城市的主人计划修订,工业发展,地形学的因素,沿海的区域开垦,交通扩大,和人口的城市的空间扩大生长。最后,岛上的每个潜在的决定因素的效果城市的空间扩大被结束。岛城市的空间扩大是不独立却交往的自然、社会经济的因素的合成的结果。布满建筑物区域扩大是岛土地的主要司机盖子和陆地使用变化。由这份报纸,我们希望提供在远处在中国,和世界贡献岛和沿海的持续都市化的合理理解的一本科学参考书。 | LI Xinhu LIN Tao ZHANG Guoqin XlAO Lishan ZHAO Qianjun CUI Shenghui | 2011 | Journal of Geographical Sciences2011，21，3： | 10 |
| 3 | Remote sensing based monitoring of interannual variations in vegetation activity in China from 1982 to 2009显示文摘Terrestrial vegetation is one of the most important components of the Earth's land surface. Variations in terrestrial vegetation directly impact the Earth system's balance of material and energy. This paper describes detected variations in vegetation activity at a national scale for China based on nearly 30 years of remote sensing data derived from NOAA/AVHRR(1982–2006) and MODIS(2001–2009). Vegetation activity is analyzed for four regions covering agriculture, forests, grasslands, and China's Northwest region with sparse vegetation cover(including regions without vegetation). Relationships between variations in vegetation activity and climate change as well as agricultural production are also explored. The results show that vegetation activity has generally increased across large areas, especially during the most recent decade. The variations in vegetation activity have been driven primarily by human factors, especially in the southern forest region and the Northwest region with sparse vegetation cover. The results further show that the variations in vegetation activity have influenced agricultural production, but with a certain time lag. | LI Fei ZENG Yuan LI XiaoSong ZHAO QianJun WU BingFang | 2014 | Science China Earth Sciences2014，57，8： | 8 |
| 4 | Strategies for engineering advanced nanomedicines for gas therapy of cancer显示文摘As an emerging and promising treatment method,gas therapy has attracted more and more attention for treatment of inflammation-related diseases,especially cancer.However,therapeutic/therapy-assisted gases(NO,CO,HgS,H2,O2,SO and CO2)and most of their prodrugs lack the abilities of active intratumoral accumulation and controlled gas release,resulting in limited cancer therapy efficacy and potential side effects.Therefore,development of nanomedicines to realize tumor-targeted and controlled release of therapeutic/therapy-assisted gases is greatly desired,and also the combination of other therapeutic modes with gas therapy by multifunctional nanocarrier platforms can augment cancer therapy efficacy and also ced gas-releasingnanomedicines from four aspects:(1)stimuli-responsive strategies for controlled gas release;multi-model combination strategies based on gas therapy.Moreover,we highlight current issues and gaps in knowledge,and envisage current trends and future prospects of advanced nanomedicines for gas therapy of cancer.This review aims to inspire and guide the engineering of advanced gas-releasing nanomedicines.reduce their side effects.The design ofnanomedicines with these functions is vitally important,but challenging.In this review,we summarize a series of engineering strategies for construction of advar(2)catalytic strategies for controlled gas release;(3)tumor-targeted gas delivery strategies;(4) | Yingshuai Wang Tian Yang Qianjun He | 2020 | National Science Review2020，7，9： | 7 |
| 5 | Energy Storage Performance of a PCM in the Solar Storage Tank显示文摘High-temperature solar thermal power station with solar energy storage is one of the effective ways to solve energy shortage and environmental pollution. The heat storage characteristics of phase change materials in solar energy storage tanks directly affect the performance of the system and its future promotion and utilization. Based on the knowledge of heat transfer, fluid mechanics and engineering thermodynamics, this paper uses MATLAB software to compile the dynamic heat storage characteristics calculation program of phase change materials in energy storage tanks, and verify the results. This paper analyzes the phase change heat storage process with three PCM initial temperatures and three HTF speeds. The results show that when the initial temperature of the PCM changes from 185°C to 210°C, the latent heat storage heat increases by 21.8%, and the total heat storage decreases. Increasing the HTF speed from 1.8 m/s to 2.2 m/s, the melting time was reduced from 414 minutes to 390 minutes, and the total heat storage and sensible heat storage were also increased. The results also show that changing the initial temperature of the PCM and the flow rate of the HTF will change the thermal storage performance of the system. The research has certain reference significance for mastering the basic principle of high temperature solar thermal power generation system and promoting the application of the system. | MAO Qianjun CHEN Hongzhang YANG Yizhi | 2019 | Journal of Thermal Science2019，28，2： | 6 |
| 6 | A New Carbon and Oxygen Balance Model Based on Ecological Service of Urban Vegetation显示文摘The application of human induced oxygen consumption and carbon emission theory in urban region was summed up and on this base a new model of urban carbon and oxygen balance (UCOB) was constructed by calculating the carbon and oxygen fluxes. The purpose was to highlight the role of vegetation in urban ecosystems and evaluate the effects of various human activities on urban annual oxygen consumption and carbon emission. Hopefully,the model would be helpful in theory to keep the regional balance of carbon and oxygen,and provide guidance and support for urban vegetation planning in the future. To test the UCOB model,the Jimei District of Xiamen City,Fujian Province,China,a very typical urban region,was selected as a case study. The results turn out that Jimei′s vegetation service in oxygen emission and carbon sequestration could not meet the demand of the urban population,and more than 31.49 times of vegetation area should be added to meet the whole oxygen consumption in Jimei while 9.60 times of vegetation area are needed to meet the carbon sequestration targets. The results show that the new UCOB model is of a great potential to be applied to quantitative planning of urban vegetation and regional eco-compensation mechanisms. | YIN Kai ZHAO Qianjun LI Xuanqi CUI Shenghui HUA Lizhong LIN Tao | 2010 | Chinese Geographical Science2010，20，2： | 6 |
| 7 | Solid oxide fuel cells in combination with biomass gasification for electric power generation显示文摘Biomass,a source of renewable energy,represents an effective substitute to fossil fuels.Gasification is a process that organics are thermochemically converted into valuable gaseous products(e.g.biogas).In this work,the catalytic test demonstrated that the biogas produced from biomass gasification mainly consists of H2,CH4,CO,and CO2,which were then be used as the fuel for solid oxide fuel cell(SOFC).Planar SOFCs were fabricated and adopted.The steam reforming of biogas was carried out at the anode of a SOFC to obtain a hydrogen-rich fuel.The performance of the SOFCs operating on generated biogas was investigated by I-V polarization and electrochemical impedance spectra characterizations.An excellent cell performance was obtained,for example,the peak power density of the SOFC reached 1391 mW·cm-2 at 750℃when the generated biogas was used as the fuel.Furthermore,the SOFC fuelled by simulated biogas delivered a very stable operation. | Huangang Shi Qianjun Li Wenyi Tan Hao Qiu Chao Su | 2020 | Chinese Journal of Chemical Engineering2020，28，4： | 6 |
| 8 | Convolutional adaptive denoising autoencoders for hierarchical feature extraction显示文摘Convolutional neural networks (CNNs)are typical structures for deep learning and are widely used in image recognition and classification.However,the random initialization strategy tends to become stuck at local plateaus or even diverge,which results in rather unstable and ineffective solutions in real applications.To address this limitation, we propose a hybrid deep learning CNN-AdapDAE model, which applies the features learned by the AdapDAE algorithm to initialize CNN filters and then train the improved CNN for classification tasks.In this model,AdapDAE is proposed as a CNN pre-training procedure,which adaptively obtains the noise level based on the principle of annealing,by starting with a high level of noise and lowering it as the training progresses.Thus,the features learned by AdapDAE include a combination of features at different levels of granu- larity.Extensive experimental results on STL-10,CIFAR-10, and MNIST datasets demonstrate that the proposed algorithm performs favorably compared to CNN (random filters),CNNAE (pre-training filters by autoencoder),and a few other unsupervised feature learning methods. | Qianjun ZHANG Lei ZHANG | 2018 | Frontiers of Computer Science2018，12，6： | 5 |
| 9 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 10 | Light-triggered nitric oxide release and structure transformation of peptide for enhanced intratumoral retention and sensitized photodynamic therapy显示文摘Tumor-targeted delivery of nanomedicine is of great importance to improve therapeutic efficacy of cancer and minimize systemic side effects.Unfortunately,nowadays the targeting efficiency of nanomedicine toward tumor is still quite limited and far from clinical requirements.In this work,we develop an innovative peptide-based nanoparticle to realize light-triggered nitric oxide(NO)release and structural transformation for enhanced intratumoral retention and simultaneously sensitizing photodynamic therapy(PDT).The designed nanoparticle is self-assembled from a chimeric peptide monomer,TPP-RRRKLVFFK-Ce6,which contains a photosensitive moiety(chlorin e6,Ce6),aβ-sheet-forming peptide domain(Lys-Leu-Val-Phe-Phe,KLVFF),an oligoarginine domain(RRR)as NO donor and a triphenylphosphonium(TPP)moiety for targeting mitochondria.When irradiated by light,the constructed nanoparticles undergo rapid structural transformation from nanosphere to nanorod,enabling to achieve a significantly higher intratumoral accumulation by 3.26 times compared to that without light irradiation.More importantly,the conversion of generated NO and reactive oxygen species(ROS)in a light-responsive way to peroxynitrite anions(ONOO)with higher cytotoxicity enables NO to sensitize PDT in cancer treatment.Both in vitro and in vivo studies demonstrate that NO sensitized PDT based on the well-designed transformable nanoparticles enables to eradicate tumors efficiently.The light-triggered transformable nanoplatform developed in this work provides a new strategy for enhanced intratumoral retention and improved therapeutic outcome. | Lingdong Jiang Danyang Chen Zhaokui Jin Chao Xia Qingqing Xu Mingjian Fan Yunlu Dai Jia Liu Yuanpei Li Qianjun He | 2022 | Bioactive Materials2022，7，6： | 3 |
| 11 | Sharp bounds for Hardy type operators on higher-dimensional product spaces显示文摘Abstract We investigate a class of fractional Hardy type operators Hβ2,β2,...βm defined on higher-dimensional product spaces R^n1×R^n2×...R^nm and use novel methods to obtain their sharp result due to S.M.Wang,S.Z.Lu,and D.Y.Yan. | Qianjun HE Xiang LI Dunyan YAN | 2018 | Frontiers of Mathematics in China2018，13，6： | 3 |
| 12 | Equivalence of operator norm for Hardy-Littlewood maximal operators and their truncated operators on Morrey spaces显示文摘We will prove that for 1 | Xingsong ZHANG Mingquan WEI Dunyan YAN Qianjun HE | 2020 | Frontiers of Mathematics in China2020，15，1： | 2 |
| 13 | Effects of Inclusion of Chrysin in Cucurbit[8]uril on Its Stability, Solubility and Antioxidant Potential显示文摘 | XU Zhiling LIAN Xiaowei LI Mengjie ZHANG Xiaodong WANG Yi TAO Zhu ZHANG Qianjun | 2017 | Chemical Research in Chinese Universities2017，33，5： | 2 |
| 14 | Determination of water content in corn stover silage using near-infrared spectroscopy显示文摘The aim of this study was to evaluate the feasibility of utilizing near-infrared spectroscopy to determine the water content of corn stover silage across a wide range.The water contents of 208 samples were measured,and their corresponding near-infrared spectra were simultaneously collected.The effects of different preprocessing methods,such as derivation,standard normal variety(SNV),multiplicative scatter correction(MSC),and non-preprocessing methods for the obtained near-infrared spectra on the performance of calibration models were compared.The calibration models were established by modified partial least squares(MPLS)regression.The results showed that the calibration model developed from the successive preprocessing of MSC and first-order derivation(1-D)achieved the optimal performance.The correlation coefficients of the calibration and validation subset were 0.974 and 0.949,respectively,and the standard errors of the calibration and cross validation were 4.249% and 4.256%,respectively.External validation was performed on 60 samples.The correlation coefficient between the measured and predicted values of the calibration model was 0.973 and the prediction model’s relative percent deviation was 4.317.This indicated that the mathematical model of near-infrared spectroscopy predicted the water content in corn stover silage with high accuracy.The study showed that the near-infrared spectroscopy technology can be used for rapid and non-destructive testing across a wide range of water contents in the corn stover silage. | Maoqun Zhang Chao Zhao Qianjun Shao Zidong Yang Xuefen Zhang Xiaofeng Xu Muhammad Hassan | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 2 |
| 15 | Whole-genome sequencing reveals selection signals among Chinese,Pakistani,and Nepalese goats显示文摘The goat(Capra hircus)is one of the oldest domesticated animal species,with archeological evidence indicating that its earliest domestication from the wild ancestor(bezoar)occurred in the Fertile Crescent 10,000 calibrated calendar years ago(Zeder and Hesse,2000).A variety of well-adapted goat breeds with excellent economic traits have been selected artificially and naturally for human needs in China,Pakistan,and Nepal.For example,cashmere goat breeds produce fine cashmere wool and are mainly distributed on the Himalayan Plateau(e.g.,Nepal and Tibet)and in cold northern China(e.g.,Inner Mongolia and Liaoning).The Toggenburg dairy goat is the most productive breed of dairy goat and is distributed in at least 50 countries on all continents(Ferro et al.,2017).Pakistani ewes are reared mostly for meat and wool purposes,but some are used as dairy goats,such as the Bugi Toori goat and Pateri goat(Bilal et al.,2018).Additionally,indigenous goats of the southern Asian regions are well adapted to the local hot environment.Their unique traits and biodiversity serve as genetic resources that can be used for the artificial breeding of goats.Recently,several studies have provided patterns of genome-wide characteristics in goat populations to explore the underlying genetic basis of trait formation and environmental adaptability in China(Zhang et al.,2018),Pakistan(Kumar et al.,2018),and Nepal(Sasazaki et al.,2021),respectively.However,due to the proximity of these geographic regions,the profiles of genetic differences,gene flow,and common genes related to high trait performance between goat populations from China,Pakistan,and Nepal remain unclear. | Yefang Li Ying Gong Zhengkai Zhang Ling Li Xuexue Liu Xiaohong He Qianjun Zhao Yabin Pu Yuehui Ma Lin Jiang | 2023 | Journal of Genetics and Genomics2023，50，5： | 2 |
| 16 | Effect of Jianpi Bushen formula on aromatase-inhibitor-associated bone loss after menopause显示文摘OBJECTIVE: To investigate the effect of Jianpi Bushen(JPBS) formula on aromatase inhibitor(AI)-associated bone loss after menopause.METHODS: Six-month-old female rats were randomly divided into 6 groups: a sham group, an ovariectomized(OVX) group, an OVX treated with exemestane and 3 OVX groups each treated with a different dose of JPBS formula. Bone mineral density(BMD) at the lumbar vertebrae, histology, bone markers and serum levels of estrogen were assessed. Furthermore, a cohort study was conducted in 130 postmenopausal women with breast cancer that had undergone treatment with AIs. The subjects were given JPBS + caltrate D or caltrate D only, administered orally. BMD at the lumbar vertebrae and femoral neck and bone markers were evaluated in both control and herbal treatment groups at baseline and 12 months.RESULTS: Experimental results indicated that a high dose of JPBS significantly increased the trabecular bone area percentage(Tb.Ar %) and broadened the trabecular thickness(Tb.Th). The JPBS formula enriched the carboxyterrninal propeptide of type ipmcollagen and increased serum estrogen level significantly. The clinical investigation revealed that bone loss was decreased in the group treated with JPBS vs control(BMD T score at lumbar vertebrae, 3.9% increased vs 14.58% decreased, respectively, P = 0.004 and BMD T score on femoral neck, 1.8% decreased vs 22.45% decreased, respectively, P = 0.008). Besides, JPBS formula elevated Nmiddle osteocalcin and decreased type Ⅰ collagen cross-linked C-terminal telopeptide.CONCLUSION: JPBS formula prevented aromatase-inhibitor-associated bone loss after menopause by inhibiting bone resorption and promoting bone formation. | Dai Yan Chen Qingqing Guan Ruodan Xu Rui Qiu Chang Song Xue Guo Qianqian Wang Zhiyu Chen Qianjun | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 2 |
| 17 | Camptothecin@HMSNs/thermosensitive hydrogel composite for applications in preventing local breast cancer recurrence显示文摘Camptothecin has a strong tumor killing ability for a variety of tumor cells with its special anti-cancer mechanism including the breast cancer. However, because of its infinite hydrophobic property, its clinical application has been greatly limited. Early prevention of loco regional recurrence for the breast cancer is critical for patients who have undergone breast-conserving therapy. In the study,CPT was used for the inhibition of the recurrence after the operation. The hollow mesoporous silica nanoparticles were used as the carrier to improve the hydrophilic property and increase its bioavailability with the high loading capacity. The ability of the cellular uptake and antitumor activity was increased. Hydrogel was the ideal carrier for local therapy, so the CPT@HMSNs were loaded into the PLEL thermo sensitive hydrogel to be injected into the tumor sites after the tumor was resected. The recurrence was reduced in the group of CPT-HMSNs-PLEL and the side effect of CPT was decreased. They exhibit distinguished potential as drug carrier for local delivery. | Jing Wu Ying Qu Kun Shi Bingyang Chu Yanpeng Jia Xue Xiao Qianjun He Zhiyong Qian | 2018 | Chinese Chemical Letters2018，29，12： | 2 |
| 18 | Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing显示文摘It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm.H_(2)is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability.In this work,we propose a concept of sonocatalytic hydrogen/hole-combined’inside/outside-cooperation’anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric nanomaterials.Proof-of-concept experiments using C_(3)N_(4)nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H_(2)and holes rapidly penetrate into biofilm to inhibit bacterial energy metabolism and oxidatively deprive polysaccharides/NADH in biofilm to destroy the bacterial membrane/electron transport chain,respectively,inside/outside-cooperatively eradicating biofilm.A bacteria-infected diabetic wound model is used to confirm the excellent in vivo antibacterial performance of sonocatalytic hydrogen/hole-combined therapy,remarkably improving bacteria-infe cted diabetic wound healing.The proposed strategy of sonocatalytic hole/hydrogen-combined’inside/outside-cooperation’will make a highway for treatment of deep-seated biofilm infection. | Qingqing Xu Shengqiang Chen Lingdong Jiang Chao Xia Lingting Zeng Xiaoqing Cai Zhaokui Jin Shucun Qin Wenjiang Ding Qianjun He | 2023 | National Science Review2023，10，5： | 2 |
| 19 | The mechanism of a railway landslide caused by rainfall显示文摘 | Qianjun Xu Limin Zhang | 2010 | Landslides2010，7，4： | 1 |
| 20 | Fe-porphyrin:A redox-related biosensor of hydrogen molecule显示文摘Hydrogen molecule(H_(2))exhibits broad-spectrum but microenvironment-dependent biomedical effects in varied oxidation stress-related diseases,but its molecular mechanism is unclear and its targeting molecule is unknown so far.Herein,we originally reveal that Fe-porphyrin is a H_(2)-targeted molecule.We have demonstrated that the oxidized Fe-porphyrin in both free and protein-confining states can self-catalyze the hydrogenation/reduction by reacting with H_(2)to catalytically scavenge∙OH,and can also catalytically hydrogenate to reduce CO_(2)into CO in the hypoxic microenvironment of in vitro simulation and in vivo tumor,confirming that Fe-porphyrin is a redox-related biosensor of H_(2)and H_(2)is an upstream signaling molecule of CO.These discoveries are favorable for deep understanding and exploration of profound biomedical effects of H2,and helpful for development of innovative drugs and hydrogen energy/agricultural materials. | Zhaokui Jin Penghe Zhao Wanjun Gong Wenjiang Ding Qianjun He | 2023 | Nano Research2023，16，2： | 1 |
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