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| 1 | Systematic review and meta-analysis on the association of tuberculosis in Crohn's disease patients treated with tumor necrosis factor-α inhibitors(Anti-TNFα)显示文摘AIM To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis(TB) infection in Crohn's disease(CD) patients treated with tumor necrosis factoralpha(TNFα) inhibitors.METHODS A meta-analysis of randomized, double-blind, placebocontrolled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction(EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds.RESULTS Twenty-three clinical trial studies were identified, including 5669 patients. Six TB infection cases were reported across 5 studies, all from patients receiving TNFα inhibitors. Eighteen studies reported no TB infection cases in placebo and TNFα inhibitor treatment arms. TB infection risk was significantly increased among patients receiving TNFα inhibitors, with a risk difference of 0.028(95%CI: 0.0011-0.055). The odds ratio was 4.85(95%CI: 1.02-22.99) with EBC and 5.85(95%CI: 1.13-30.38) without EBC.CONCLUSION The risk of TB infection is higher among CD patients receiving TNFα inhibitors. Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly Mycobacterium avium subspecies paratuberculosis, which ultimately could worsen their clinical condition. | Brent L Cao Ahmad Qasem Robert C Sharp Latifa S Abdelli Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，25： | 4 |
| 2 | Meteorological factors, aeroallergens and asthma-related visits in Kuwait: a 12-month retrospective study 显示文摘 | Qasem J A Nasrallah H A1-Khalaf B N | 2008 | Ann Saudi Med2008，28，： | 1 |
| 3 | Nitric: oxide regulates local arterial distensibility in vivo显示文摘 | Wilkinson B Qasem A McEniery M | 2002 | Circulation2002，105，2： | 1 |
| 4 | Fungicidal activity of some common weed extracts against different plant pathogenic fungi 显示文摘 | Qasem J R Abu-blan H A | 1996 | Journal of Phytopathology1996，144，： | 1 |
| 5 | Antifungal activity of aqueous extracts from some common weed species显示文摘 | Qasem J R Abu-blan H A | 1995 | Annuals of Applied Biology1995，127，1： | 1 |
| 6 | Multi-objective hybrid evolutionary algorithms for radial basis function neural network design 显示文摘 | QASEM S N SHAMSUDD1N S M ZAIN A M | 2012 | Knowledge-Based Systems2012，27，1： | 1 |
| 7 | Endothelin-1 regulates arterial pulse wave velocity in vivo 显示文摘 | McEniery C M Qasem A Schmitt M | 2003 | J Am Coll Cardiol2003，42，11： | 1 |
| 8 | Meteorological factors,aeroallergens and asthma-related visits in Kuwait :a 12 month retrospective sludy显示文摘 | Qasem J A Nasrallah H AI khalaf B N | 2008 | Ann Saudi Med2008，28，6： | 1 |
| 9 | In-situ observation of deep water corals in the northern Red Sea waters of Saudi Arabia显示文摘 | QURBAN M A KRISHNAKUMAR P K JOYDAS T V MANIKANDAN K P ASHRAF T T M QUADRI S 1 WAFAR M QASEM A CAIRNS S D | 2014 | Deep Sea Research Part I: Oceanographic Research Papets2014，89，： | 1 |
| 10 | Nitric oxide regulates local arterial distensibility in vivo 显示文摘 | Wilkinson IB Qasem A McEniery CM | 2002 | Circulation2002，105，2： | 1 |
| 11 | Isolation of Streptococcus agalactiae from cultured silver pomfret, Pampus argenteus (Euphrasen), in Kuwait显示文摘 | Duremdez R Al-Marzouk A Qasem J | 2004 | J Fish Dis2004，27，30： | 1 |
| 12 | Discriminating imaging findings of acute osteoporotic vertebral fracture:a prospective multicenter cohort study显示文摘 | Qasem K Suzuki A Yamada K | 2014 | J Orthop Surg Res2014，9，1： | 1 |
| 13 | Endothelin-Ⅰ regulates artenial pulse wave velocity in vivo显示文摘 | McEnieny CM Qasem A Schmitt M | 2003 | J Am Coll Cardiol2003，42，11： | 1 |
| 14 | Peripheral 'oscillatory' compliance is associated with aortic augmentation index显示文摘 | Segers P Qasem A De Backer T | 2001 | Hypertens2001，37，6： | 1 |
| 15 | Nitric oxide regulates local arterial distensibility in vivo 显示文摘 | Wilkinson I B Qasem A McEniery C M | 2002 | Circulation2002，105，2： | 1 |
| 16 | Nitric oxid : regulates local artery distensibility in vivo显示文摘 | Wilkinson IB Qasem A McEniery CM | 2002 | Circulatian2002，105，2： | 1 |
| 17 | Meteorological factor,aeroallergens and asthma-related visits in kuwait: a 12- month retrospective study显示文摘 | Qasem J A Nasrallah H A1 Khalaf B N | 2008 | Ann Saudi Med2008，28，6： | 1 |
| 18 | Nitric oxide regulates local arterial distensibility in vivo 显示文摘 | WILKINSON IB QASEM A MCENIERY CM | 2002 | Circulation2002，105，2： | 1 |
| 19 | Nitric oxide regulates local arterial distensibility in vivo显示文摘 | Wikinson B Qasem A McEniery M | 2002 | Circulation2002，105，2： | 1 |
| 20 | Role of natriuretic peptides in regulation of conduit artery distensibility 显示文摘 | Schmitt M Qasem A McEniery C | 2004 | Am J Physiol Heart Circ Physio12004，56，5： | 1 |
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