| 1 | Aurora-A 激酶的研究进展显示文摘Aurora激酶家族是一组近年来发现的调节中心体和微管功能的丝氨酸/苏氨酸蛋白激酶,在细胞有丝分裂的正常进程中起着非常重要的作用。相关研究表明在一些实体肿瘤如乳腺癌、卵巢癌、食管癌、结肠癌、肺癌及膀胱癌等肿瘤中均出现Aurora-A基因的高表达。目前,Aurora-A激酶作为肿瘤治疗的一个新的靶点,已经逐渐引起人们重视,其小分子抑制剂的研究和使用,尤其是与化疗药物的联合应用,将成为今后恶性肿瘤治疗的新方向。本文对近几年国内外在Aurora-A激酶的研究,对其生物学功能、与肿瘤的关系及其抑制剂的研究进展进行综述。 | 郑向前(综述) 高明(综述) 任秀宝(综述) Jin Q.Cheng(审校) | 2014 | 中国肿瘤临床2014，41，4： | 9 |
| 2 | Unveiling anneal hardening in dilute Al-doped Al_(x)CoCrFeMnNi(x = 0,0.1) high-entropy alloys显示文摘Anneal hardening has been one of the approaches to improve mechanical properties of solid solution alloys with the face-centered cubic(FCC) structure,whereby a considerable strengthening can be attained by annealing of cold-worked alloys below the recrystallization temperature(T_(rx)).Microscopically,this hardening effect has been ascribed to several mechanisms,i.e.solute segregation to defects(dislocation and stacking fault) and short-range chemical ordering,etc.However,none of these mechanisms can well explain the anneal hardening recently observed in phase-pure and coarse-grained FCC-structured high-entropy alloys(HEAs).Here we report the observations,using high-resolution electron channeling contrast imaging and transmission electron microscopy,of profuse and stable dislocation substructures in a cold-rolled CoCrFeMnNi HEA subject to an annealing below T_(rx).The dislocation substructures are observed to be thermally stable up to T_(rx),which could arise from the chemical complexity of the high-entropy system where certain elemental diffusion retardation occurs.The microstructure feature is markedly different from that of conventional dilute solid solution alloys,in which dislocation substructures gradually vanish by recovery during annealing,leading to a strength drop.Furthermore,dilute addition of 2 at.% Al leads to a reduction in both microhardness and yield strength of the cold-rolled and subsequently annealed(≤500℃) HEA.This Al induced softening effect,could be associated with the anisotropic formation of dislocation substructure,resulting from enhanced dislocation planar slip due to glide plane softening effect.These findings suggest that the strength of HEAs can be tailored through the anneal hardening effect from dislocation substructure strengthening. | Q.Cheng X.D.Xu P.Xie L.L.Han J.Y.He X.Q.Li J.Zhang Z.T.Li Y.P.Li B.Liu T.G.Nieh M.W.Chen J.H.Chen | 2021 | Journal of Materials Science & Technology2021，，32： | 3 |
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