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| 1 | Hepatitis B virus infection in Latin America:A genomic medicine approach显示文摘Hepatitis B virus(HBV)infection is the leading cause of severe chronic liver disease.This article provides a critical view of the importance of genomic medicine for the study of HBV infection and its clinical outcomes in Latin America.Three levels of evolutionary adaptation may correlate with the clinical outcomes of HBV infection.Infections in Latin America are predominantly of genotype H in Mexico and genotype F in Central and South America;these strains have historically circulated among the indigenous population.Both genotypes appear to be linked to a benign course of disease among the native and mestizo Mexicans and native South Americans.In contrast,genotypes F,A and D are common in acute and chronic infections among mestizos with Caucasian ancestry.Hepatocellular carcinoma is rare in Mexicans,but it has been associated with genotype F1b among Argentineans.This observation illustrates the significance of ascertaining the genetic and environmental factors involved in the development of HBV-related liver disease in Latin America,which contrast with those reported in other regions of the world. | Sonia Roman Alexis Jose-Abrego Nora Alma Fierro Griselda Escobedo-Melendez Claudia Ojeda-Granados Erika Martinez-Lopez Arturo Puro | 2014 | World Journal of Gastroenterology2014，20，23： | 4 |
| 2 | 优化磁性粒子为基础的系统的DNA纯化方案的重要性显示文摘从复杂生物基质中快速、高效地分离核酸是在获取各种实验的最佳起始原料的重要一步。磁性粒子为基础的操作流程提供了一个快速简单的解决方案,它特别适合用于自动化,在获得纯净和完整的DNA或RNA时以最少的动手时间获得良好的重现性结果。因此,必须优化基于磁珠的纯化流程来达到最高质量与数量的核酸提取。本文介绍了一个自动化、高速、以磁性粒子为基础的纯化系统来实现理想的DNA纯化方案,并考察了不同搅拌速度组合,以及在洗脱步骤的加热效应对DNA纯化数量和质量的影响。 | Marika SUOMALAINEN Sini SUOMALAINEN Virpi PURO Vuokko KYTNIEMI Arja LAMBERG | 2010 | 生命科学仪器2010，8，6： | 2 |
| 3 | Diabetes-induced dysfunction of the glutamate transporter in retinal Mfiller cells 显示文摘 | Li Q Puro DG | 2002 | Invest Ophthalmol Vis Sci2002，43，9： | 1 |
| 4 | Bidding strategies for real-life small loan auctions显示文摘 | Puro Lj Teich J E Wallenius H | 2011 | Decision Support Systems2011，51，1： | 1 |
| 5 | Tumor necrosis factor activates a conserved innate antiviral response to hepatitis B virus that destabilizes nucleocapsids and reduces nuclear viral DNA显示文摘 | Puro R Schneider RJ | | 0，，： | 1 |
| 6 | Risk of exposure to blood bone infection for Italian health care workers by job category and work area显示文摘 | Puro V Carli GD Petrosillo N | 2001 | Infection Control of Hospital Epidemiol2001，22，4： | 1 |
| 7 | Occupational humah immunodeficieney virus infection in health care workers: worldwide cases through September1997 显示文摘 | Ippolito G Puro V Heptonstall J | 1999 | Clin Infect Dis1999，28，： | 1 |
| 8 | Diabetes-induced dysfunction of the glutamate trans- porter in retinal muller cells显示文摘 | Li Q Puro DG | 2002 | Invest ophthalmol Vis Sci2002，43，9： | 1 |
| 9 | Estimating diagnostic accuracy of tests for latent tuberculosis infection without a gold standard among healthcare workers显示文摘 | Girardi E Angeletti C Puro V | | 0，，： | 1 |
| 10 | Frequency of detection of respiratory viruses in the lower respiratory tract of hospitalized adults显示文摘 | Minossc C Selleri M Zaniratti MS Cappiello G Longo R Schifano E Span6 A Petrosillo N Lauria FN Puro V Capobianchi MR | 2008 | J Clin Vriol2008，42，2： | 1 |
| 11 | Sevoflurane titration u- sing bispectral index decreases postoperative vomiting in phase Ⅱ recov- ery after ambulatory surgery 显示文摘 | Nelskyla KA Yli-Hankala AM Puro HP | 2001 | Anesth Analg2001，93，5： | 1 |
| 12 | The Italian Study Group on Occupational Risk of HIV Infection in health care workers显示文摘 | IPPOLITO G PURO V DE CARLI G | 1993 | Arch Intern Med1993，153，3： | 1 |
| 13 | Effects of angiotensin II on the pericyte-containing microvascμLature of the rat retina J Physiol显示文摘 | Kawamura H Kobayashi M Li Q Yamanishi S Katsumura K Minami M Wu DM Puro DG | 2004 | 561(3) :671-6832004，561，3： | 1 |
| 14 | Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication显示文摘 | Bouchard M J Puro R J Wang L | | 0，，14： | 1 |
| 15 | Borrower De- cision Aid for people - to - people lending 显示文摘 | Puro L Teich J E Wallenius H | 2010 | Decision Support Systems2010，49，1： | 1 |
| 16 | Bidding strat- egies for real - life small loan auctions 显示文摘 | Puro L Teich J E Wallenius H | 2011 | Decision Support Systems2011，51，1： | 1 |
| 17 | Molecularepidemiology of a hepatitis C virus epidemic in ahaemodialysis unit : outbreak investigation and infectionoutcome显示文摘 | LANINI S ABBATE I PURO V | 2010 | BMC Infect Dis2010，10，： | 1 |
| 18 | Tumor necrosis factor alpha inhibition of hepatitis B virus replication involves disruption of capsid integrity through activation of NF- kappaB 显示文摘 | Biermer M Puro R Schneider RJ | 2003 | Virol2003，77，7： | 1 |
| 19 | Bidding strategies for real-life small loan auctions显示文摘 | Puro L Teich J E Wallenius H | 2011 | Decision Support Systems2011，51，1： | 1 |
| 20 | Risk of exposure to bloodborne infection for Italian healthcare workers, by job category and work area显示文摘 | Calri GD Petrosilo N | 2001 | Infect Control Hosp Epidemiol2001，22，4： | 1 |
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