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| 1 | New challenges in perioperative management of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of cancer-related death in the industrialized world.Despite progress in the understanding of the molecular and genetic basis of this disease,the5-year survival rate has remained low and usually does not exceed 5%.Only 20%-25%of patients present with potentially resectable disease and surgery represents the only chance for a cure.After decades of gemcitabine hegemony and limited therapeutic options,more active chemotherapies are emerging in advanced PDAC,like 5-Fluorouracil,folinic acid,irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine,that have profoundly impacted therapeutic possibilities.PDAC is considered a systemic disease because of the high rate of relapse after curative surgery in patients with resectable disease at diagnosis.Neoadjuvant strategies in resectable,borderline resectable,or locally advanced pancreatic cancer may improve outcomes.Incorporation of tissue biomarker testing and imaging techniques into preoperative strategies should allow clinicians to identify patients who may ultimately achieve curative benefit from surgery.This review summarizes current knowledge of adjuvant and neoadjuvant treatment for PDAC and discusses the rationale for moving from adjuvant to preoperative and perioperative therapeutic strategies in the current era of more active chemotherapies and personalized medicine.We also discuss the integration of good specimen collection,tissue biomarkers,and imaging tools into newly designed preoperative and perioperative strategies. | Francesco Puleo Raphaёl Maréchal Pieter Demetter Maria-Antonietta Bali Annabelle Calomme Jean Closset Jean-Baptiste Bachet Jacques Deviere Jean-Luc Van Laethem | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 2 | Recombinant creatine kinase proteins and proposed standards for creatine kinase isoenzymes and subforms assays显示文摘 | Friedman D L Kesterson R Puleo P | 1993 | Clin Chem1993，39，8： | 1 |
| 3 | Poroelastic Plate and Shell Theories显示文摘 | Taber L A Puleo A M | 1996 | Solid Mechanics and its Applications1996，，35： | 1 |
| 4 | Thyrotropin suppression by metformin in a cohort of patients with differentiated thyroid cancer in follow-up显示文摘 | Citarrella R Puleo L Chiofalo F | 2009 | Endocrine Abstracts2009，20，： | 1 |
| 5 | Osteoblast responses to orthopedic implant materials in vitro显示文摘 | Puleo D A Holleran L A Doremus R H | 1991 | J Biomed Mater Res1991，25，6： | 1 |
| 6 | Revisional bariatric surgery: who, what, where, and when?显示文摘 | Radtka JR Puleo FJ Wang L | 2010 | Surg Obes Re- lat Dis2010，6，6： | 1 |
| 7 | Flexible Applications of the Coping Cat Program for Anxious Youth显示文摘 | Beidas R S Benjamin C L Puleo C M | 2010 | Cogn Behav Pract2010，17，2： | 1 |
| 8 | Grain refined and basal textured surface produced by burnishing for improved corrosion performance of AZ31B Mg alloy 显示文摘 | PU Z SONG G L YANG S OUTEIRO J C DILLON 0 W Jr PULEO D A JAW AHIR I S | 2012 | Corrosion Science2012，57，： | 1 |
| 9 | Revisional bariatric surgery: who, what, where, and when? 显示文摘 | Radtka JF 3rd Puleo FJ Wang L | 2010 | Surg Obes Relat Dis2010，6，： | 1 |
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