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| 1 | Utility of fluorescent cholangiography during laparoscopic cholecystectomy: A systematic review显示文摘AIM: To verify the utility of fluorescent cholangiography for more rigorous identification of the extrahepatic biliary system.METHODS: MEDLINE and Pub Med searches were performed using the key words 'fluorescent cholangiography', 'fluorescent angiography', 'intraoperative fluorescent imaging', and 'laparoscopic cholecystectomy' in order to identify relevant articles published in English, French, German, and Italian during the years of 2009 to 2014. Reference lists from the articles were reviewed to identify additional pertinent articles. For studies published in languages other than those mentioned above, all available information was collected from their English abstracts. Retrieved manuscripts(case reports, reviews, and abstracts) concerning the application of fluorescent cholangiography were reviewed by the authors, and the data were extracted using a standardized collection tool. Data were subsequently analyzed with descriptive statistics. In contrast to classic meta-analyses, statistical analysis was performed where the outcome was calculated as the percentages of an event(without comparison) in pseudo-cohorts of observed patients.RESULTS: A total of 16 studies were found that involved fluorescent cholangiography during standard laparoscopic cholecystectomies(n = 11), singleincision robotic cholecystectomies(n = 3), multiport robotic cholecystectomy(n = 1), and single-incision laparoscopic cholecystectomy(n = 1). Overall, these preliminary studies indicated that this novel technique was highly sensitive for the detection of important biliary anatomy and could facilitate the prevention of bile duct injuries. The structures effectively identified before dissection of Calot's triangle included the cystic duct(CD), the common hepatic duct(CHD), the common bile duct(CBD), and the CD-CHD junction. A review of the literature revealed that the frequenciesof detection of the extrahepatic biliary system ranged from 71.4% to 100% for the CD, 33.3% to 100% for the CHD, 50% to 100% for the CBD, and 25% to 100% for the CD-CHD junction. However, the frequency of visualization of the CD and the CBD were reduced in patients with a body mass index > 35 kg/m2 relative to those with a body mass index < 35 kg/m2(91.0% and 64.0% vs 92.3% and 71.8%, respectively).CONCLUSION: Fluorescent cholangiography is a safe procedure enabling real-time visualization of bile duct anatomy and may become standard practice to prevent bile duct injury during laparoscopic cholecystectomy. | Antonio Pesce Gaetano Piccolo Gaetano La Greca Stefano Puleo | 2015 | World Journal of Gastroenterology2015，21，25： | 21 |
| 2 | Adjusting CA19-9 values to predict malignancy in obstructive jaundice:Influence of bilirubin and C-reactive protein显示文摘AIM:To find a possible relationship between inflammation and CA19-9 tumor marker by analyzing data from patients with benign jaundice(BJ) and malignant jaundice(MJ).METHODS:All patients admitted for obstructive jaundice,in the period 2005-2009,were prospectively enrolled in the study,obtaining a total of 102 patients.On admission,all patients underwent complete standard blood test examinations including C-reactive protein(CRP),bilirubin,CA19-9.Patients were considered eligible for the study when they presented obstructive jaundice confirmed by instrumental examinations and increased serum bilirubin levels(total bilirubin > 2.0 mg/dL).The standard cut-off level for CA19-9 was 32 U/mL,whereas for CRP this was 1.5 mg/L.The CA19-9 level was adjusted by dividing it by the value of serum bilirubin or by the CRP value.The patients were divided into 2 groups,MJ and BJ,and after the adjustment a comparison between the 2 groups of patients was performed.Sensitivity,specificity and positive predictive values were calculated before and after the adjustment.RESULTS:Of the 102 patients,51 were affected by BJ and 51 by MJ.Pathologic CA19-9 levels were found in 71.7% of the patients.In the group of 51 BJ patients there were 29(56.9%) males and 22(43.1%) females with a median age of 66 years(range 24-96 years),whereas in the MJ group there were 24(47%) males and 27(53%) females,with a mean age of 70 years(range 30-92 years).Pathologic CA19-9 serum level was found in 82.3% of MJ.CRP levels were pathologic in 66.6% of the patients with BJ and in 49% with MJ.Bilirubin and CA19-9 average levels were significantly higher in MJ compared with BJ(P = 0.000 and P = 0.02),while the CRP level was significantly higher in BJ(P = 0.000).Considering a CA19-9 cut-off level of 32 U/mL,82.3% in the MJ group and 54.9% in the BJ group were positive for CA19-9(P = 0.002).A CA19-9 cut-off of 100 U/mL increases the difference between the two groups:35.3% in BJ and 68.6% in MJ(P = 0.0007).Adjusting the CA19-9 value by dividing it by serum bilirubin level meant that 21.5% in the BJ and 49% in the MJ group remained with a positive CA19-9 value(P = 0.003),while adjusting the CA19-9 value by dividing it by serum CRP value meant that 31.4% in the BJ group and 76.5% in the MJ group still had a positive CA19-9 value(P = 0.000004).Sensitivity,specificity,positive predictive values of CA19-9 > 32 U/mL were 82.3%,45% and 59.1%;when the cutoff was CA19-9 > 100 U/mL they were,respectively,68.6%,64.7% and 66%.When the CA19-9 value was adjusted by dividing it by the bilirubin or CRP values,these became 49%,78.4%,69.4% and 76.5%,68.6%,70.9%,respectively.CONCLUSION:The present study proposes CRP as a new and useful correction factor to improve the diag-nostic value of the CA19-9 tumor marker in patients with cholestatic jaundice. | Gaetano La Greca Maria Sofia Rosario Lombardo Saverio Latteri Agostino Ricotta Stefano Puleo Domenico Russello | 2012 | World Journal of Gastroenterology2012，18，31： | 20 |
| 3 | Colorectal cancer and lymph nodes:The obsession with the number 12显示文摘Lymphadenectomy of colorectal cancer is a decisive factor for the prognostic and therapeutic staging of the patient.For over 15 years,we have asked ourselves if the minimum number of 12 examined lymph nodes(LNs)was sufficient for the prevention of understaging.The debate is certainly still open if we consider that a limit of 12 LNs is still not the gold standard mainly because the research methodology of the first studies has been criticized.Moreover many authors report that to date both in the United States and Europe the number'12'target is uncommon,not adequate,or accessible only in highly specialised centres.It should however be noted that both the pressing nature of the debate and the dissemination of guidelines have been responsible for a trend that has allowed for a general increase in the number of LNs examined.There are different variables that can affect the retrieval of LNs.Some,like the surgeon,the surgery,and the pathology exam,are without question modifiable;however,other both patient and disease-related variables are non-modifiable and pose the question of whether the minimum number of examined LNs must be individually assigned.The lymph nodal ratio,the sentinel LNs and the study of the biological aspects of the tumor could find valid application in this field in the near future. | Giovanni Li Destri Isidoro Di Carlo Roberto Scilletta Beniamino Scilletta Stefano Puleo | 2014 | World Journal of Gastroenterology2014，20，8： | 4 |
| 4 | New challenges in perioperative management of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of cancer-related death in the industrialized world.Despite progress in the understanding of the molecular and genetic basis of this disease,the5-year survival rate has remained low and usually does not exceed 5%.Only 20%-25%of patients present with potentially resectable disease and surgery represents the only chance for a cure.After decades of gemcitabine hegemony and limited therapeutic options,more active chemotherapies are emerging in advanced PDAC,like 5-Fluorouracil,folinic acid,irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine,that have profoundly impacted therapeutic possibilities.PDAC is considered a systemic disease because of the high rate of relapse after curative surgery in patients with resectable disease at diagnosis.Neoadjuvant strategies in resectable,borderline resectable,or locally advanced pancreatic cancer may improve outcomes.Incorporation of tissue biomarker testing and imaging techniques into preoperative strategies should allow clinicians to identify patients who may ultimately achieve curative benefit from surgery.This review summarizes current knowledge of adjuvant and neoadjuvant treatment for PDAC and discusses the rationale for moving from adjuvant to preoperative and perioperative therapeutic strategies in the current era of more active chemotherapies and personalized medicine.We also discuss the integration of good specimen collection,tissue biomarkers,and imaging tools into newly designed preoperative and perioperative strategies. | Francesco Puleo Raphaёl Maréchal Pieter Demetter Maria-Antonietta Bali Annabelle Calomme Jean Closset Jean-Baptiste Bachet Jacques Deviere Jean-Luc Van Laethem | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 5 | Small scale biodiesel synthesis from waste frying oil and crude methanol in Morocco显示文摘Biodiesel was produced at small scale by transesterification of used frying oil(UFO) recovered from Moroccan pastry shops and fish frying restaurants. Biodiesel was first synthesised at laboratory scale in order to optimize the transesterification parameters. The cost of the final product was also optimized using low-cost raw materials.The UFO and the produced biodiesel were characterized with several techniques including gas chromatography,1H NMR,13 C NMR, FTIR, and TGA–TDA techniques.1H NMR gas chromatographic analyses of the final product confirmed that the transesterification in the chosen experimental conditions was completed. These results were confirmed by TGA–TDA analysis used as new techniques to monitoring triglyceride conversion. The biodiesel did not contain any trace of glycerol, and it did meet the international standards. The transesterification at low cost in small scale conditions was performed at 60 °C using 1.2% of KOH and a methanol/oil molar ratio of 6:1. A yield of 80.8% was achieved. The properties of the produced biodiesel were found to be as good as those of biodiesels obeying to European standards. The biodiesel production was also performed at small-scale for individual utilisation. Thus, the product was tested in a kerosene stove for heating and non-modified commercial diesel engine producing electricity. | Fatiha Ouanji Marouane Nachid Mohamed Kacimi Leonarda F.Liotta Fabtizio Puleo Mahfoud Ziyad | 2016 | Chinese Journal of Chemical Engineering2016，24，9： | 3 |
| 6 | Gut Failure in the ICU显示文摘 | Francesco Puleo Marianna Arvanitakis André Van Gossum Jean-Charles Preiser | 2011 | Semin Respir Crit Care Med2011，，05： | 2 |
| 7 | Noninvasive detection of allograft re- jection in heart transplant recipients by use of Doppler tissue imaging 显示文摘 | Puleo JA Aranda JM Weston MW | 1998 | J Heart Lung Transplant1998，17，2： | 1 |
| 8 | Gut failure in the ICU 显示文摘 | Puleo F Arvanitakis M Van Gossum A | 2011 | Semin Respir Crit Care Med2011，32，5： | 1 |
| 9 | Gut failure in the ICU 显示文摘 | Puleo F Arvanitakis M Van Gossum A | 2011 | Semin Respir Crit Care Med2011，32，5： | 1 |
| 10 | A technique to immobilize bioactive proteins, including bone morphogenetic protein-4 (BMP-4) on titanium alloy显示文摘 | Puleo DA Kissling RA Shet MS | 2002 | Biomaterials2002，23，9： | 1 |
| 11 | Health care system factors and colorectal cancer screening显示文摘 | Zapka J G Puleo E Vickers-Lahti M | 2002 | Am J Prev Med2002，23，1： | 1 |
| 12 | Quantification of swash flows using video-based particle image velocimetry显示文摘 | K.T Holland J.A Puleo T.N Kooney | 2001 | Coastal Engineering2001，，2： | 1 |
| 13 | Animal models for periodontal disease显示文摘 | Oz HS Puleo DA | 2011 | J Biomed Biotechnol2011，2011，75： | 1 |
| 14 | Endometrialadenocarcinoma within a single horn of a didelphic uterus: areport of 2 cases显示文摘 | Molpus KL Puleo JG Williams AM | 2004 | J Reprod Med2004，49，2： | 1 |
| 15 | Gut failure in the ICU 显示文摘 | Puleo F Arvanitakis M Van Gossum A | 2011 | Semin Respir Crit Care Med2011，32，5： | 1 |
| 16 | Implant surfaces 显示文摘 | Puleo DA Thomas MV | 2006 | Dent Clin North Am2006，50，3： | 1 |
| 17 | 显示文摘 | XieA Skatrud JB Puleo DS | 2002 | Am J Respir Crit Care Med2002，165，： | 1 |
| 18 | Grain refined and basal textured surface produced by burnishing for improved corrosion performance of AZ31B Mg alloy显示文摘 | Z. Pu G.-L. Song S. Yang J.C. Outeiro O.W. Dillon D.A. Puleo I.S. Jawahir | 2011 | Corrosion Science2011，，： | 1 |
| 19 | Noninvasive detection of allograft rejection in heart transplant recipients by use of Doppler tissue imaging显示文摘 | Puleo JA Aranda JM WestonMW | 1998 | J Heart Lung Transplant1998，17，： | 1 |
| 20 | Infection, Inflammation, and Bone Regeneration a Paradoxical Relationship显示文摘 | THOMAS M V PULEO D A | 2011 | Journal of dental re- search2011，90，9： | 1 |
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