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| 1 | Outcome of curative resection for perihilar cholangiocarcinoma in Northeast Thailand显示文摘AIM: To examine survival outcomes of perihilar cholangiocarcinoma(PCCA) resection including mortality, morbidity and prognostic factors. METHODS: Multivariate analyses were carried out based on the survival data of all patients with histologically confirmed PCCA who underwent curative resection at Srinagarind Hospital from January 2006 to December 2011. RESULTS: There were 29(19%) cases of intrahepatic CCA that involved hilar and 124(81%) with hilar bileduct cancer. R0 resection was carried out on 66(43.1%) patients of whom 50(32.7%) also had lymph node metastasis. The other patients underwent R1 resection. The overall 5-year survival rate was 20.6%(95%CI: 13.8-28.4) and median survival time was 19.9 mo. Postoperative mortality was 2%, and 30% of patients had complications. Patients without lymph node metastasis were 60% less likely to die than those with metastasis. Achieving R0 led to a 58% reduction in the chance of mortality as compared to R1. CONCLUSION: To achieve a better survival outcome, focus should center on performing radical surgery and detection of patients with early stage cancer. | Attapol Titapun Ake Pugkhem Vor Luvira Tharatip Srisuk Ongart Somintara O-tur Saeseow Anan Sripanuskul Anongporn Nimboriboonporn Bandit Thinkhamrop Narong Khuntikeo | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 5 |
| 2 | Efficacy of metal and plastic stents in unresectable complex hilar cholangiocarcinoma: a randomized controlled trial显示文摘 | Apichat Sangchan Worrarat Kongkasame Ake Pugkhem Kriangsak Jenwitheesuk Pisaln Mairiang | 2012 | Gastrointestinal Endoscopy2012，，1： | 3 |
| 3 | Expression of sialyl Lewis^a relates to poor prognosis in cholangiocarcinoma显示文摘AIM: High levels of serum sialyl Lewisa (sLea) are frequently found in cholangiocarinnoma (CCA) patients and have been suggested to be a serum marker for CCA. However, the significance of this antigen in CCA is unknown. In this study,the clinical significance of sLea expression in CCA tissues and the possible role of sLea in vascular invasion in vitro were elucidated.METHODS: Expression of sLea in tumor tissues of 77patients with mass-forming CCA and 33 with periductal infiltrating CCA was determined using immunohistochemistry.The in vitro assays on adhesion and transmigration of CCA cells to human umbilical vein endothelial cells were compared between CCA cell lines with and without sLea expression.RESULTS: sLea was aberrantly expressed in 60% of CCA tumor tissues. A significant relationship was found between the frequency of sLea expression and the mass-forming type CCA (P = 0.041), well differentiated histological grading (P = 0.029), and vascular invasion (P = 0.030). Patients with positive sLea expression had a significantly poorer prognosis (21.28 wk, 95% CI = 16.75-25.81 wk) than those negative for sLea (37.30 wk, 95% CI = 27.03-47.57 wk)(P<0.001). Multivariate analysis with adjustment for all covariates showed that patients positive for sLea possessed a 2.3-fold higher risk of death than patients negative for sLea (P<0.001). The role of sLea in vascular invasion was demonstrated using in vitro adhesion and transmigration assays. KKU-M213, a human CCA cell-line with a high expression of sLea, adhered and transmigrated to IL-1β-activated endothelial cells of the human umbilical vein more than KKU-100, the line without sLea expression (P<0.001).These processes were significantly diminished when the antibodies specific to either sLea or E-selectin were added to the assays (P<0.001).CONCLUSION: This study demonstrates the clinical significance of sLea expression in vascular invasion, and an unfavorable outcome in CCA. The role of sLea in vascular invasion which may lead to poor prognosis is supported by the in vitro adhesion and transmigration studies. | Apa Juntavee Banchob Sripa Ake Pugkhem Narong Khuntikeo Sopit Wongkham | 2005 | World Journal of Gastroenterology2005，11，2： | 2 |
| 4 | Intrahepatic cholangiocarcinoma in Thailand显示文摘 | Thongueb Uttaravichien Vajarabhongsa Bhudhisawasdi Chawalit Pairojkul Ake Pugkhem | 1999 | Journal of Hepato - Biliary - Pancreatic Surgery1999，，2： | 1 |
| 5 | Efficacy of metal and plastic stents in unresectable complex hilar cholangiocarcinoma: a randomized controlled trial显示文摘 | Apichat Sangchan Worrarat Kongkasame Ake Pugkhem Kriangsak Jenwitheesuk Pisaln Mairiang | 2012 | Gastrointestinal Endoscopy2012，，1： | 1 |
| 6 | Intrahepatic cholangiocarcinoma in Thailand显示文摘 | Thongueb Uttaravichien Vajarabhongsa Bhudhisawasdi Chawalit Pairojkul Ake Pugkhem | 1999 | Journal of Hepato - Biliary - Pancreatic Surgery1999，，2： | 1 |
| 7 | Major hepatic resection for hilar cholangiocarcinoma without preoperative biliary drainage显示文摘 | Khuntikeo N Pugkhem A Bhudhisawasdi V | 2008 | Asian Pac J Cancer Prev2008，9，1： | 1 |
| 8 | Major hepatic resection for hilar cholangiocarcinoma without preoperative biliary drainage显示文摘 | KHUNTIKEO N PUGKHEM A BHUDHISAWASDI V | 2008 | Asian Pac J Cancer Prev2008，9，1： | 1 |
| 9 | Major hepatic resection for hilar eholangiocareinoma without preoperative biliary drainage显示文摘 | Khuntikeo N Pugkhem A Bhudhisawasdi V | 2008 | Asian Pac J Cancer Prev2008，9，1： | 1 |
| 10 | Abdominal angiostrongyliasis caused by Angiostrongylus cantonensis : A possible cause of eosinophilie infiltration in human digestive tract显示文摘 | Sawanyawisuth K Pugkhem A Mitchai J | 2010 | Pathol Res Pratt2010，206，2： | 1 |
| 11 | Abdominal angio strongyliasis caused by Angiostrongylus cantonensis:a possible causeof eosinophilic infiltration in human digestive tract显示文摘 | Sawanyawisuth K Pugkhem A Mitchai J | 2010 | Pathol ResPract2010，206，2： | 1 |
| 12 | Compliance with enhanced recovery after surgery predicts long-term outcome after hepatectomy for cholangiocarcinoma显示文摘BACKGROUND Enhanced recovery after surgery(ERAS)program has been proved to improve postoperative outcome for many surgical procedures,including liver resection.There was limited evidence regarding the feasibility and benefit of ERAS in patients who underwent liver resection for cholangiocarcinoma.AIM To evaluate the feasibility of ERAS in patients who underwent liver resection for cholangiocarcinoma and its association with patient outcomes.METHODS We retrospectively analyzed 116 cholangiocarcinoma patients who underwent hepatectomy at Srinagarind Hospital,Khon Kaen University between January 2015 and December 2016.The primary outcome was the compliance with ERAS.To determine the association between ERAS compliance and patient outcomes.the patients were categorized into those adhering more than and equal to 50%(ERAS≥50),and below 50%(ERAS<50)of all components.Details on type of surgical procedure,preoperative and postoperative care,tumor location,postoperative laboratory results,and survival time were evaluated.The compliance with ERAS was measured by the percentage of ERAS items achieved.The Kaplan-Meier curve was used for survival analysis.RESULTS The median percentage of ERAS goals achieved was 40%(±12%).Fourteen patients(12.1%)were categorized into the ERAS≥50 group,and 102 patients were in the ERAS<50 group.Postoperative hospital stay was significantly shorter in the ERAS≥50 group[8.9 d,95%confidence interval(CI):7.3-10.4 d]than in the ERAS<50 group(13.7 d,95%CI:12.2-15.2 d)(P=0.0217).No hepatobiliary-related complications or in-hospital mortality occurred in the ERAS≥50 group.Overall survival was significantly higher in the ERAS≥50 group.The median survival of the patients in the ERAS<50 group was 1257 d(95%CI:853.2-1660.8 d),whereas that of the patients in the ERAS≥50 group was not reached.CONCLUSION Overall ERAS compliance for patients who underwent liver resection for cholangiocarcinoma is poor.Greater ERAS compliance could predict in-hospital,short-term,and long-term outcomes of the patients. | Chaowasaporn Jongkatkorn Vor Luvira Chalisa Suwanprinya Kantaruthai Piampatipan Natwutpong Leeratanakachorn Theerawee Tipwaratorn Attapol Titapun Tharatip Srisuk Suapa Theeragul Apiwat Jarearnrat Vasin Thanasukarn Ake Pugkhem Narong Khuntikeo Chawalit Pairojkul Supot Kamsa-Ard Vajarabhongsa Bhudhisawasdi | 2023 | World Journal of Gastrointestinal Surgery2023，15，3： | 1 |
| 13 | Orotate phosphoribosyl transferase mRNA expression and the response of cholangiocarcinoma to 5-fluorouracil显示文摘AIM:To determine whether expression of certain enzymes related to 5-fluorouracil(5-FU)metabolism predicts 5-FU chemosensitivity in cholangiocarcinoma(CCA).METHODS:The histoculture drug response assay(HDRA)was performed using surgically resected CCA tissues.Tumor cell viability was determined morphologically with hematoxylin and eosin-and terminal deoxynucleotide transferase-mediated dUTP nick-end labeling-stained tissues.The mRNA expression of thymidine phosphorylase(TP),orotate phosphoribosyl transferase(OPRT),thymidylate synthase(TS),and dihydropyrimidine dehydrogenase(DPD)was determined with realtime reverse transcriptase-polymerase chain reaction.The levels of gene expression and the sensitivity to 5-FU were evaluated.RESULTS:Twenty-three CCA tissues were obtained from patients who had been diagnosed with intrahepatic CCA and who underwent surgical resection at Srinagarind Hospital,Khon Kaen University from 2007 to 2009.HDRA was used to determine the response of these CCA tissues to 5-FU.Based on the dose-response curve,200μg/mL 5-FU was selected as the test concentration.The percentage of inhibition index at the median point was selected as the cut-off point to differentiate the responding and non-responding tumors to 5-FU.When the relationship between TP,OPRT,TS and DPD mRNA expression levels and the sensitivity of CCA tissues to 5-FU was examined,only OPRT mRNA expression was significantly correlated with the response to 5-FU.The mean expression level of OPRT was significantly higher in the responder group compared to the non-responder group(0.41±0.25 vs 0.22±0.12,P<0.05).CONCLUSION:OPRT mRNA expression may be a useful predictor of 5-FU chemosensitivity of CCA.Whether OPRT mRNA could be used to predict the success of 5-FU chemotherapy in CCA patients requires confirmation in patients. | Chariya Hahnvajanawong Jariya Chaiyagool Wunchana Seubwai Vajarabhongsa Bhudhisawasdi Nisana Namwat Narong Khuntikeo Banchob Sripa Ake Pugkhem Wichittra Tassaneeyakul | 2012 | World Journal of Gastroenterology2012，18，30： | 0 |
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