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| 1 | Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis显示文摘BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an epiphenomenon.This study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe hypertriglyceridemia.METHODS:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum triglycerides.The APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being taken.The patients' progression,etiological diagnosis,hospital stay and clinical and radiological severity were all recorded.RESULTS:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) origin.Compared with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes mellitus.They usually consumed alcohol or consumed it excessively on the days before admission.Also,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption. | Radka Ivanova Susana Puerta Alfonso Garrido Ignacio Cueto Ana Ferro María José Ariza Andrés Cobos Pedro González-Santos Pedro Valdivielso | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 26 |
| 2 | Portal hypertensive biliopathy: A single center experience and literature review显示文摘Portal hypertensive biliopathy (PHB) is characterized by anatomical and functional abnormalities of the intrahepatic, extrahepatic and pancreatic ducts, in patients with portal hypertension associated to extrahepatic portal vein obstruction and less frequently to cirrhosis. These morphological changes, consisting in dilatation and stenosis of the biliary tree, are due to extensive venous collaterals occurring in an attempt to decompress the portal venous blockage. It is usually asymptomatic until it progresses to more advanced stages with cholestasis, jaundice, biliary sludge, gallstones, cholangitis and finally biliary cirrhosis. Imaging mo-dalities of the biliary tree such as Doppler ultrasound, computed tomography, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography are essential to establish the diagnosis and the need of therapeutical interventions. Once the diagnosis is established, treatment with ursodesoxycholic acid seems to be beneficial. Decompression of the biliary tree to dilate, remove stones or implant biliary prosthesis by endoscopic or surgical procedures (hepato-yeyunostomy) usually resolves the cholestatic picture and prevents septic complications. The ideal treatment is the decompression of the portal system, with transjugular intrahepatic porto-systemic shunt or a surgical porto-systemic shunt. Unfortunately, few patients will be candidates for these procedures due to the extension of the thrombotic process. The purpose of this paper is to report the first 3 cases of PHB seen in a Colombian center and to review the literature. | Vanessa Suárez Andrés Puerta Luisa Fernanda Santos Juan Manuel Pérez Adriana Varón Rafael Claudino Botero | 2013 | World Journal of Hepatology2013，5，3： | 10 |
| 3 | Nuclear domain 10 of the viral aspect显示文摘Nuclear domain 10(ND10) are spherical bodies distributed throughout the nucleoplasm and measuring around 0.2-1.0 μm. First observed under an electron microscope, they were originally described as dense bodies found in the nucleus. They are known by a number of other names, including Promyelocytic Leukemia bodies(PML bodies), Kremer bodies, and PML oncogenic domains. ND10 are frequently associated with Cajal bodies and cleavage bodies. It has been suggested that they play a role in regulating gene transcription. ND10 were originally characterized using human autoantisera, which recognizes Speckled Protein of 100 kD a, from patients with primary biliary cirrhosis. At the immunohistochemical level, ND10 appear as nuclear punctate structures, with 10 indicating the approximate number of dots per nucleus observed. ND10 do not colocalize with kinetochores, centromeres, sites of mR NA processing, or chromosomes. Resistance of ND10 antigens to nuclease digestion and salt extraction suggest that ND10 are associated with the nuclear matrix.They are often identified by immunofluorescent assay using specific antibodies against PML, Death domainassociated protein, nuclear dot protein(NDP55), and so on. The role of ND10 has long been the subject of investigation, with the specific connection of ND10 and viral infection having been a particular focus for almost 20 years. This review summarizes the relationship of ND10 and viral infection. Some future study directions are also discussed. | Yisel A Rivera-Molina Francisco Puerta Martínez Qiyi Tang | 2013 | World Journal of Virology2013，2，3： | 7 |
| 4 | Marginal pricing of transmission service: an analysis of cost recovery 显示文摘 | PEREZ-ARRIAGA I J RUBIO F J PUERTA J F | 1995 | IEEE Trans on Power Systems1995，10，1： | 2 |
| 5 | Widespread dispersal of the microsporidian Nosema ceranae , an emergent pathogen of the western honey bee, Apis mellifera显示文摘 | Julia Klee Andrea M. Besana Elke Genersch Sebastian Gisder Antonio Nanetti Dinh Quyet Tam Tong Xuan Chinh Francisco Puerta José Maria Ruz Per Kryger Dejair Message Fani Hatjina Seppo Korpela Ingemar Fries Robert J. Paxton | 2007 | Journal of Invertebrate Pathology2007，，1： | 2 |
| 6 | Effect of PCs superplasticizers on the rheological properties and hydration process of slag-blended cement pastes显示文摘 | M. Palacios F. Puertas P. Bowen Y. F. Houst | 2009 | Journal of Materials Science2009，，10： | 2 |
| 7 | Effect of PCs superplasticizers on the rheological properties and hydration process of slag-blended cement pastes显示文摘 | M Palacios F Puertas P Bowen | 2009 | J Mater Sci2009，，44： | 1 |
| 8 | Alkali-activated slag cements:kinetic studies显示文摘 | FERNANDEZ-JIMENEZ A PUERTAS F | 1997 | Cem Concr Res1997，27，3： | 1 |
| 9 | Leptin administration to cold acclimated rats reduces both food intake and brown adipose tissue thermogenesis 显示文摘 | Abelenda M Ledesma A Rial E Puerta M | 2003 | Journal of Thermal Biology2003，28，： | 1 |
| 10 | Differences between structural and functional environmental heterogeneity caused by seed dispersal 显示文摘 | Gemez J M Valladares F Puerta C | 2004 | Functional Ecology2004，18，6： | 1 |
| 11 | Colloidal Stability of Polymer Colloids with Variable Surface Charge 显示文摘 | PUERTAS A M NIEVES F J D L | 1999 | Journal ofColloid and Interface Science1999，216，2： | 1 |
| 12 | Determination of kinetic equations of alkaline activation of blast furnace slag by means of calorimetric data显示文摘 | FERNANDEZ-JIMENEZ A PUERTAS F ARTEAGA A | 1998 | J Therm Anal Calori1998，52，2： | 1 |
| 13 | Development of an immunochromatographic method to determineβ–lactoglobulin at trace levels显示文摘 | Puerta A Diez–Masa J C Frutos M | 2005 | Analytica Chimica Acta2005，537，： | 1 |
| 14 | Mite allergens显示文摘 | FERNNDEZ-CALDAS E PUERTA L CARABALLO L | 2005 | Clinical Allergy and Immunology2005，5，5： | 1 |
| 15 | Determination of volatile aldehydes forevaluafionof in vitro antioxidant activity 显示文摘 | Elena E Stashenko M A Puertas J R | 2002 | Anal Bioanal Chem2002，373，： | 1 |
| 16 | Methodology for developing technological tables used in EDM processes of conductive ceramics显示文摘 | Luis J Puertas I | 2007 | Journal of Materials Processing Technology2007，189，： | 1 |
| 17 | Deveolopment of an immunochromatographic method to determine β- lactoglobulin at trace levels 显示文摘 | Angel Puerta Jose Carlos Diez-Masa Mercedes de Frutos | 2005 | Analytica Chimica Acta2005，537，： | 1 |
| 18 | Surgical treatment of eosinophilic granuloma in the thoracic spine in patients with neurological lesions显示文摘 | Puertas EB Milani C Chagas JC | 2003 | J Pediatr Orthop B2003，12，5： | 1 |
| 19 | Dietary trans fatty acids affect doeosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats 显示文摘 | LARQUE E LLAMAS F P PUERTA V | 2000 | Pediatr Res2000，47，2： | 1 |
| 20 | Nutritional Constraints Determine the Expression of a Sexual Trait in the House Sparrow, Passer domesticus显示文摘 | Jose P. Veiga Marisa Puerta | 1996 | Proceedings of the Royal Society B: Biological Sciences . 1996 (1367)1996，，： | 1 |
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