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		题名	作者	年代	出处	被引量
	1	Mitochondrial protection by low doses of insulin-like growth factor-Ⅰin experimental cirrhosis显示文摘AIM: To characterize the mitochondrial dysfunction in experimental cirrhosis and to study whether insulin-like growth factor-Ⅰ(IGF-Ⅰ) therapy (4 wk) is able to induce beneficial effects on damaged mitochondria leading to cellular protection. METHODS: Wistar rats were divided into three groups: Control group, untreated cirrhotic rats and cirrhotic rats treated with IGF-Ⅰtreatment (2 μg/100 g bw/d). Mitochondrial function was analyzed by flow cytometry in isolated hepatic mitochondria, caspase 3 activation was assessed by Western blot and apoptosis by TUNEL in the three experimental groups. RESULTS: Untreated cirrhotic rats showed a mitochon- drial dysfunction characterized by a significant reduction of mitochondrial membrane potential (in status 4 and 3); an increase of intramitochondrial reactive oxigen species (ROS) generation and a significant reduction of ATPase activity. IGF-Ⅰtherapy normalized mitochondrial func-tion by increasing the membrane potential and ATPase activity and reducing the intramitochondrial free radical production. Activity of the electron transport complexes Ⅰand Ⅲ was increased in both cirrhotic groups. In addition, untreated cirrhotic rats showed an increase of caspase 3 activation and apoptosis. IGF-Ⅰtherapy reduced the expression of the active peptide of caspase 3 and resulted in reduced apoptosis.	Raquel Pérez María García-Fernández Matías Díaz-Sánchez Juan E Puche Gloria Delgado Marian Conchillo Jordi Muntané Inma Castilla-Cortázar	2008	World Journal of Gastroenterology2008，14，17：	11
	2	Regulation of angiogenesis by hypoxia : role of the HIF system 显示文摘	Puch C W Ratcliffe P J	2003	Nat Med2003，9，6：	1
	3	Interleukin‐6 as a predictor of cardiovascular events in troponin‐negative non‐ST elevation acute coronary syndrome patients显示文摘	J. M. García‐Salas A. Tello‐Montoliu S. Manzano‐Fernández T. Casas‐Pina A. López‐Cuenca P. Pérez‐Berbel C. Puche‐Morenilla P. Martínez‐Hernández M. Valdés F. Marín	2014	Int J Clin Pract2014，，3：	1
	4	Morphology and performance of epoxy nanocomposites modified with organoclay and rubber显示文摘	Liu W P Suong V HO A Martin Puch	2004	Polymer Engineering and Science2004，44，6：	1
	5	Treatment of biliary injuries after laparoseopic eholeeystectomy: retrospective study of 27 pa- tients显示文摘	Puche P Jacquet E Borie F	2007	J Chir2007，144，5：	1
	6	Ultrasensitive pheromone detection by mammalian vomeronasal neurons 显示文摘	Zufall T L Lane A P Puche A C Mat W Novotny M V Shipley M T Zufall F	2000	Nature2000，405，：	1
	7	Evaluation of in- guinal hernia in ambulatory surgery: A prospective mono- centric study on 1009 inguinal hernia 显示文摘	Jacquet E Puche P Alahyane J	2006	Ambul Surg2006，12，4：	1
	8	Restoration of the DNA Damage Resistance of Deinococcus radiodurans DNA Polymerase Mutants by Escherichia coli DNA Polymerase Ⅰ and Klenow Fragment显示文摘	GUTMAN P D PUCHS P MINTON K W	1994	Mutat Res1994，314，：	1
	9	Cirrhosis:candidates for liver transplantation显示文摘	Jacquet E Puche P Jaber S	2005	Rev Prat2005，55，14：	1

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