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	题名	作者	年代	出处	被引量
1	Mitochondrial protection by low doses of insulin-like growth factor-Ⅰin experimental cirrhosis显示文摘AIM: To characterize the mitochondrial dysfunction in experimental cirrhosis and to study whether insulin-like growth factor-Ⅰ(IGF-Ⅰ) therapy (4 wk) is able to induce beneficial effects on damaged mitochondria leading to cellular protection. METHODS: Wistar rats were divided into three groups: Control group, untreated cirrhotic rats and cirrhotic rats treated with IGF-Ⅰtreatment (2 μg/100 g bw/d). Mitochondrial function was analyzed by flow cytometry in isolated hepatic mitochondria, caspase 3 activation was assessed by Western blot and apoptosis by TUNEL in the three experimental groups. RESULTS: Untreated cirrhotic rats showed a mitochon- drial dysfunction characterized by a significant reduction of mitochondrial membrane potential (in status 4 and 3); an increase of intramitochondrial reactive oxigen species (ROS) generation and a significant reduction of ATPase activity. IGF-Ⅰtherapy normalized mitochondrial func-tion by increasing the membrane potential and ATPase activity and reducing the intramitochondrial free radical production. Activity of the electron transport complexes Ⅰand Ⅲ was increased in both cirrhotic groups. In addition, untreated cirrhotic rats showed an increase of caspase 3 activation and apoptosis. IGF-Ⅰtherapy reduced the expression of the active peptide of caspase 3 and resulted in reduced apoptosis.	Raquel Pérez María García-Fernández Matías Díaz-Sánchez Juan E Puche Gloria Delgado Marian Conchillo Jordi Muntané Inma Castilla-Cortázar	2008	World Journal of Gastroenterology2008，14，17：	11
2	Low Doses of Insulin-Like Growth Factor I Improve Insulin Resistance, Lipid Metabolism, and Oxidative Damage in Aging Rats 显示文摘	Mari a Garci a-Fema'ndez Gloria Delgado Juan Enrique Puche et al	2007	Endocrinology2007，149，5：	1
3	Surgical treatment of child nevus 显示文摘	Fink Puches R Soyer HP	2000	Eur J Surg2000，10，：	1
4	TOX4 and its binding partners recognize DNA adducts generated by platinum anticancer drugs显示文摘	Bounaix Morand du Puch C Barbier E Kraut A	2011	Arch Biochem Biophys2011，507，2：	1
5	From progenitors to integrated neurons: role of neurotransmitters in adult olfactory neurogenesis显示文摘	Bovetti S Gribaudo S Puche AC	2011	J Chem Neuroanat2011，42，4：	1
6	Regulation of angiogenesis by hypoxia : role of the HIF system 显示文摘	Puch C W Ratcliffe P J	2003	Nat Med2003，9，6：	1
7	Intravitreal rainbizumab for macular oedema secondary to retinal vein occlusion: a retrospective study of 34 eyes显示文摘	Puche N Glacet A Mimoun G	2012	Ac- ta Ophtalmol2012，90，4：	1
8	Human conditions of insulin - like growth factor- 1 (IGF- I ) deficiency 显示文摘	Puche JE CastiUa - Cort:tzar I	2012	J Transl Med2012，10，：	1
9	Olfactory cell derivation and migration 显示文摘	Puche AC Baker H	2007	J Mol Histol2007，38，：	1
10	The natural history of kyphosis in postmenopausal women 显示文摘	Puche R C Morosano M Masoni A	1995	Bone1995，17，：	1
11	The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse显示文摘	Levi G Puche AC Mantero S	2003	Mol Cell Neurosci2003，22，4：	1
12	Hepatic stellate cells and liver fibrosis显示文摘	Puche JE Saiman Y Friedman SL	2013	Compr Physiol2013，3，4：	1
13	Surgical treatment of child nevus显示文摘	Fink Puches R Soyer HP	2000	Eur J Surg2000，10，：	1
14	Effect of sodium fluoride administration to rats on bone phosphorous content and phosphatemia 显示文摘	Di Loreto V Rigalli A Puche R	2006	Arzneimittelforschung2006，56，11：	1
15	Polymers and drug delivery systems 显示文摘	Vilar G Tulla - Puche J Albericio F	2012	Curr Drug Deliv2012，9，4：	1
16	Review Diagnosis Methods of Induction Electrical Machines based on Steady State Current显示文摘	Rub(e)n Puche Panadero Joan Pons Llinares Vicente Climente Alarcon y Manuel Pineda S(a)nchez	2009	l lth Spanish Portuguese Conference On Electrical Engineering2009，，：	1
17	Serum aspirin-esterase activity in epileptic patients receiving treatment with Phenobarbital,phenytoin,carbamazepine and valproic acid显示文摘	Puche E Garcia de la Serrana H Mota C		0，，01：	1
18	N-cadherin is developmentally regulated and functionally involved in early hematopoietic cell differentiation显示文摘	Puch S Armeanu S Kibler C	2001	J Cell Sci2001，114，8：	1
19	Hepatic stellate cells and liver fibrosis显示文摘	Puche JE Yedidya S Friedman SL	2007	Arch Pathol Lab Med2007，131，11：	1
20	Capital utilization, mainte- nance costs and the business cycle 显示文摘	LICANDRO O PUCH L A	2000	Annales d''economie et de Statistique2000，，58：	1

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