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| 1 | Biotribology of artificial hip joints显示文摘Hip arthroplasty can be considered one of the major successes of orthopedic surgery, with more than 350000 replacements performed every year in the United States with a constantly increasing rate. The main limitations to the lifespan of these devices are due to tribological aspects, in particular the wear of mating surfaces, which implies a loss of matter and modification of surface geometry. However, wear is a complex phenomenon, also involving lubrication and friction. The present paper deals with the tribological performance of hip implants and is organized in to three main sections. Firstly, the basic elements of tribology are presented, from contact mechanics of ball-in-socket joints to ultra high molecular weight polyethylene wear laws. Some fundamental equations are also reported, with the aim of providingthe reader with some simple tools for tribological investigations. In the second section, the focus moves to artificial hip joints, defining materials and geometrical properties and discussing their friction, lubrication and wear characteristics. In particular, the features of different couplings, from metal-on-plastic to metal-on-metal and ceramic-on-ceramic, are discussed as well as the role of the head radius and clearance. How friction, lubrication and wear are interconnected and most of all how they are specific for each loading and kinematic condition is highlighted. Thus, the significant differences in patients and their lifestyles account for the high dispersion of clinical data. Furthermore, such consideration has raised a new discussion on the most suitable in vitro tests for hip implants as simplified gait cycles can be too far from effective implant working conditions. In the third section, the trends of hip implants in the years from 2003 to 2012 provided by the National Joint Registry of England, Wales and Northern Ireland are summarized and commented on in a discussion. | Francesca Di Puccio Lorenza Mattei | 2015 | World Journal of Orthopedics2015，6，1： | 8 |
| 2 | 从定期安全性更新报告过渡到定期受益-风险评价报告:初步经验和挑战显示文摘人用药品注册技术要求国际协调会议(ICH)提供了定期安全性更新报告指南(PSUR,ICH E2C(R1))和新的定期受益-风险评价报告指南(PBRER,ICH E2C(R2))。PBRER由PSUR演变而来,实现了从比较传统的获批后药物警戒定期总结报告到现代定期受益-风险评价总结报告的转变,根据累积信息对批准上市产品做出最新的受益-风险评价。通过总结ICH E2C PSUR指南和PBRER指南的主要区别,介绍了某跨国制药公司在由编写PSUR改为编写PBRER的转变过程中所积累的初步经验及其遇到的挑战,讨论了中国在推进药物警戒系统的背景下实行PBRER的可能性。 | 张晓兰 Lester REICH 梁冰 Donald PUCCIO Craig HAR TFORD | 2014 | 中国药物警戒2014，11，4： | 3 |
| 3 | Orthogonal frequency coding for SAW tagging and sensors显示文摘 | Puccio D Malocha D Saldanha N | 2006 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2006，53，2： | 1 |
| 4 | Induced normothermia attenuates intracranial hypertension and reduces fever burden after severe traumatic brain injury显示文摘 | Puccio AM Fischer MR Jankowitz BT | 2009 | Neurocrit Care2009，11，1： | 1 |
| 5 | Earlier appearance of the ossification center of the femoral hend in breast-fed versus formula-fed infants 显示文摘 | Narese F Puccio G Mazzucco W | 2011 | Nutrition2011，27，1112： | 1 |
| 6 | The cancer cachexia syndrome显示文摘 | Puccio M Nathanson L | 1997 | Semin Oncol1997，24，3： | 1 |
| 7 | Effect of short periods of normobaric hyperoxia on local brain tissue oxygenation and cerebrospinal fluid oxidative stress markers in severe traumatic brain injury显示文摘 | Puccio AM Hoffman LA Bayir H | | 0，，： | 1 |
| 8 | Pathophysiogical and therapeutic progress in Friedreich ataxia 显示文摘 | Puccio H Anheim M Tranchant C | 2014 | Rev Neurol(Paris)2014，170，5： | 1 |
| 9 | Permanent magnet bearings:Analysis of plane and axisymmetric V-shaped element design显示文摘 | PUCCIO F D BASSANI R CIULLI E | 2012 | Progress In Electromagnetics Research M2012，26，： | 1 |
| 10 | Recent advances in the molecular pathogenesis of Friedrcich ataxia 显示文摘 | Puccio H | 2000 | Hum Mol Genet2000，9，6： | 1 |
| 11 | RNAi screening in glioma stem-likecells identifies PFKFB4 as a key mole- cule important for cancer cell survival 显示文摘 | Goidts V Bageritz J Puccio L etal | 2012 | Oncogene2012，31，12： | 1 |
| 12 | Generation and curvature analysis of conjugate surfaces via a new approach显示文摘 | Puccio F D Gabiccini M Guiggiani M | 2006 | Mechanism and Machine Theory2006，41，4： | 1 |
| 13 | Atrial fibrillation and mild cognitive impairment:what correlation显示文摘 | Puccio D Novo G Baiamonte V | | 0，，02： | 1 |
| 14 | Multiwavelet analysis and signal processing显示文摘 | Mariantonia Cotronei Laura B Montefusco Luigia Puccio | 1998 | IEEE Trans on Circuits and SystemsⅡ:Analog and Digital Signal Processing1998，45，8： | 1 |
| 15 | Morbidly adherent placenta: evaluation of ultrasound diagnostic criteria and differentiation of placenta accreta from percreta显示文摘 | Call G Giambanco L Puccio G | 2013 | Ultrasound Obstet Gynecol2013，41，4： | 1 |
| 16 | Clinical use of a new class of anticoagulant drugs:the direct thrombin inhibitors显示文摘 | Puccio D Montalto S Valerio MC | | 0，，： | 1 |
| 17 | Induced norlnothermia attenuates intraeranial hypertension and reduces fever burden after severe traumatic brain injury显示文摘 | Puccio AM Fischer MR Jankowitz BT | 2009 | Nenrocrit Care2009，11，1： | 1 |
| 18 | Atrial fibrillation and mild cognitive impairment:what correlation?显示文摘 | Puccio D Novo G Baiamonte V | 2009 | Minerva Cardioangiol2009，57，2： | 1 |
| 19 | Multi-wavelet analysis and signal processing显示文摘 | Montrfusco Laura B Puccio Luigia | 1998 | IEEE Transactions on Circuits and systems1998，45，8： | 1 |
| 20 | Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients显示文摘 | Bayir H Marion DW Puccio AM | 2004 | J Neurotrauma2004，21，1： | 1 |
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