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您的检索式：作者名="Proby C.M."
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| 1 | 器官移植受者皮肤癌的临床病理特征:一项回顾性病例对照研究显示文摘Background: Non- melanoma skin cancers (NMSCs) are increased in organ transplant recipients, but transplant and immunocompetent squamous and basal cell carcinomas (SCCs, BCCs) have not been compared previously in a single- center study. Objective: To compare clinicopathologic features of transplant and immunocompetent NMSCs. Methods: Consecutive transplant NMSCs (60 SCCs, 100 BCCs) and immunocompetent NMSCs (40 SCCs, 125 BCCs) presenting between 1995- 1997. Results: Transplant patients were 15 years younger at time of NMSC diagnosis compared with immunocompetent individuals, and transplant tumors were often more multiple and extra cephalic. Spindle cell morphology was more common in transplant SCCs, a superficial component was more common in transplant BCCs, and histologic features of HPV infection were overrepresented in transplant tumors. Outcome was worse for transplant SCCs but not transplant BCCs. Limitations: Histologic features required to identify HPV infection have not been validated. Conclusions: These findings have direct implications for clinical care. The increased frequency and distribution of transplant NMSCs underscore the importance of whole- body surveillance. Transplant SCCs, particularly those with diffuse spindle cell change, may require more aggressive management, whereas transplant BCCs do not. Finally, our data support differences in the pathogenesis of transplant NMSC, which may influence future preventive and therapeutic strategies. | Harwood C.A. Proby C.M. McGregor J.M. 刘艳 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，4： | 0 |
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