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| 1 | Review of anticancer mechanisms of isoquercitin显示文摘This review was based on a literature search of PubM ed and Scielo databases using the keywords 'quercetin,rutin,isoquercitrin,isoquercitin(IQ),quercetin-3-glucoside,bioavailability,flavonols and favonoids,and cancer' and combinations of all the words.We collected relevant scientific publications from 1990 to 2015 about the absorption,bioavailability,chemoprevention activity,and treatment effects as well as the underlying anticancer mechanisms of isoquercitin.Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom.The subclass of flavonols receives special attention owing to their health benefits.The main components of this class are quercetin,rutin,and IQ,which is a flavonoid and although mostly found as a glycoside,is an aglycone(lacks a glycoside side chain).This compound presents similar therapeutic profiles to quercetin but with superior bioavailability,resulting in increased efficacy compared to the aglycone form.IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant,antiproliferative,anti-inflammatory,anti-hypertensive,and anti-diabetic.The protective effects of IQ in cancer may be due to actions on lipid peroxidation.In addition,the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway,mixed-lineage protein kinase 3,mitogen-activated protein kinase,apoptotic pathways,as well proinflammatory protein signaling.This review contributed to clarifying the mechanisms of absorption,metabolism,and actions of IQ and isoquercitrin in cancer. | Guilherme di Camillo Orfali Ana Carolina Duarte Vivien Bonadio Natalia Peres Martinez Maria Elisa Melo Branco de Araújo Fernanda Bruschi Marinho Priviero Patricia Oliveira Carvalho Denise Gon?alves Priolli | 2016 | World Journal of Clinical Oncology2016，7，2： | 4 |
| 2 | Neurophysiological basis of penile erection显示文摘阴茎勃起包含在中央 nervoussystem 之间的一个复杂相互作用,本地 factors.It 是调制由的一个神经与血管的事件心理并且氮的氧化物的 hormonalfactors.The 发现(没有)作为为识别生理的位于下面的重要机制和 pathophysiological eventsin 的一个细胞间的送信人或 neurotransmitter pavedthe 方法阴茎,除了提供,为新治疗学的发展的知识基于分子和房间相互作用的 ona | Fernanda B M PRIVIERO Romulo LEITE R Clinton WEBB Cleber E TEIXEIRA | 2007 | Acta Pharmacologica Sinica2007，28，6： | 3 |
| 3 | Differential effects of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil in rat aorta显示文摘 | TEIXEIRA C E PRIVIERO F B WEBB R C | 2006 | Pharmacol Exp Ther2006，316，： | 1 |
| 4 | Differential effects of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil in rat aorta显示文摘 | Teixeira C E Priviero F B Webb R C | 2006 | Pharmacology and Experimental Therapeutics2006，316，： | 1 |
| 5 | Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats显示文摘 | Zecchin H6 Priviero FB Souza CT | 2007 | Diabetes2007，56，4： | 1 |
| 6 | Vasorelaxing effects of propranolol in rat aorta and mesenteric artery:a role for nitric oxide and calcium entry blockade 显示文摘 | Priviero FB Teixeira CE Toque HA | 2006 | Clin Exp Pharmacol Physioh2006，33，56： | 1 |
| 7 | Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway inaorta of obese rats显示文摘 | Zecchin H G Priviero F B Souza C T | | 0，，4： | 1 |
| 8 | Vasorelaxing effects of propranolol in rat aorta and mesenteric artery:a role for nitric oxide and calcium entry blockade显示文摘 | Priviero FB Teixeira CE Toque HA | 2006 | Clin Exp Pharmacol Physiol2006，33，56： | 1 |
| 9 | Vascular effects of long-term propranolol administration after chronic nitric oxide blockade显示文摘 | Fernanda B.M. Priviero Cleber E. Teixeira Mário A. Claudino Gilberto De Nucci Angelina Zanesco Edson Antunes | 2007 | European Journal of Pharmacology2007，，2： | 1 |
| 10 | Neurophysiologlcal basis of penile erection显示文摘 | Priviero FB Leite R Webb RC | 2007 | Acta Pharmacol Sin2007，28，6： | 1 |
| 11 | Defective insulin and acetylcholine induction of endothelial cell - nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats显示文摘 | Zecchin HG Priviero FB Souza CT | 2007 | Diabetes2007，56，4： | 1 |
| 12 | Vasorelaxing effects of propranolol in rat aorta and mesenteric artery:a role for nitric oxide and calcium entry blockade显示文摘 | Priviero FB Teixeira CE Toque HA | 2006 | Clin Exp Pharmacol Physiol2006，33，56： | 1 |
| 13 | Upregulation of gp91phox subunit of NAD(P)H oxidase contributes to erectile dysfunction caused by long-term nitric oxide inhibition in rats:reversion by regular physical training显示文摘 | CLAUDINO M A FRANCO-PENTEADO C F PRIVIERO F B | 2010 | Urology2010，75，4： | 1 |
| 14 | Differential effects of the phosphodiesterase type 5 inhibitors sildenafil,vardenafil,and tadalafil in rat aorta显示文摘 | Teixeira C E Priviero F B Webb R C | 2006 | Pharmacology and Experimental Therapeutics2006，316，2： | 1 |
| 15 | Oxidative stress impairs vasorelaxation induced by the soluble guanylyl cyclase activator BAY 41-2272 in spontaneously hypertensive rats显示文摘 | Priviero FB Zemse SM Teixeira CE | 2009 | Am J Hypertens2009，22，5： | 1 |
| 16 | Defective insulin and acetylcholine induction of endothelial cellnitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats 显示文摘 | Zecchin HG Priviero FB Souza CT | 2007 | Diabetes2007，56，4： | 1 |
| 17 | Mechanisms underlying relaxation of rabbit aorta by BAY 41-2272, a nitric oxide-independent soluble guanylate cyclase activator 显示文摘 | PRIVIERO FB BARACAT JS TEIXEIRA CE | 2005 | Clin Exp Pharmacol Physiol2005，32，9： | 1 |
| 18 | Vasorelaxlng effects of propranolol in rat aorta and mesenteric artery: a role for nitric oxide and calcium entry blockade显示文摘 | PRIVIERO FB TEISEIRA CE TOQUE HA | 2006 | Clin Exp Pharmacol Physiol2006，33，56： | 1 |
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