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| 1 | Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity显示文摘AIM: Acute hepatitis may seldom have a fulminant course.In the treatment of this medical emergency, potential liver support measure must provide immediate and sufficient assistance to the hepatic function. The goal of our study was to study the adequacy of hepatocyte transplantation (HCTx) in two different anatomical sites, splenic parenchyma and peritoneal cavity, in a rat model of reversible acute hepatitis induced by carbon tetrachloride (CCl4).METHODS: After CCl4 intoxication, 84 male Wistar rats used as recipients were divided in to four experimental groups accordingly to their treatment: Group A (n=24): intrasplenic transplantation of 10±10^6 isolated hepatoo/tes, Group B (n=24):intrapedtoneal transplantation of 20×10^6 isolated hepatocytes attached on plastic microcarriers, Group C (n= 18): intrasplenic injection of 1 mL normal saline (sham-operated controls),Group D (n=18): intraperitoneal injection of 2.5 mL normal saline (sham-operated controls). Survival, liver function tests (LIT) and histology were studied in all four groups, on d 2,5 and 10 post-HCTx.RESULTS: The ten-day survival (and mean survival) in the 4 groups was 72.2% (8.1±3.1), 33.3% (5.4±3.4), 0%(3.1±1.3) and 33.3% (5.4±3.6) in groups A, B, C, D,respectively (PAB<0.05, PAc<0.05, P80=NS). In the final survivors, LIT (except alkaline phosphatase) and hepatic histology retumed to normal, independently of their previous therapy. Viable hepatocytes were identified within splenic parenchyma (in group A on d 2) and both in the native liver and the fatty tissue of abdominal wall (in group B on d 5).CONCLUSION: A significantly better survival of the intrasplenically transplanted animals has been demonstrated,Intraperitoneal hepatocytes failed to promptly engraft. A different timing between liver injury and intraperitoneal HCTx may give better results and merits further investigation. | Charalampos Pilichos Despina Perrea Maria Demonakou Athena Preza Ismini Donta | 2004 | World Journal of Gastroenterology2004，10，14： | 2 |
| 2 | Over expression of the human tissue kallikrein genes KLK4,5,6and 7 increases the malignant phenotype of o- varian cancer cells 显示文摘 | Prezas P Arit M J Viktorov P | 2006 | Biol Chem2006，387，6： | 1 |
| 3 | The role of human tissue kallikreins 7 and 8 in intracranial malignancies 显示文摘 | Prezas P Scofilas A Yfanti C | 2006 | Biol Chem2006，387，12： | 1 |
| 4 | Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells 显示文摘 | Prezas P Arh M J Viktorev P | 2006 | Biol Chem2006，387，6： | 1 |
| 5 | 查看详情显示文摘 | Fox D J Velde H T Preza C O'Sullivan J A Smith W H Woolsey T A | | 0，，： | 1 |
| 6 | Overexpression of the human tissue kallikrein genes KLK4,5,6,and 7 increases the malignant phenotype of ovarian cancer cells显示文摘 | Prezas P Arlt MJ | 2006 | Biol Chem2006，387，6： | 1 |
| 7 | Overexpression of the human tissue kallikrein genes KLK4,5,6,and 7 increases the malignant phenotype of ovarian cancer cells显示文摘 | Prezas P Arlt M J Viktorov P | 2006 | Biological Chemistry2006，387，6： | 1 |
| 8 | Theoretical development and experimental evaluation of imaging models for differential-interference- contrast microscopy显示文摘 | Preza C Snyder D L Conchello J A | 1999 | J Opt Soc Am A-Opt Image Sci Vis1999，16，9： | 1 |
| 9 | Overexpression of the human tissue kallikrein genes KLK4,S,6,and 7 increases the malignant phenotype of ovarian cancer cells显示文摘 | Prezas P Arlt MJ Viktorov P | 2006 | Biol Chem2006，387，6： | 1 |
| 10 | Outsider CEO Succes-sion and Firm Performance显示文摘 | JALAL A M PREZAS A P | 2012 | Journal of Econom-ics and Business2012，64，6： | 1 |
| 11 | The role of human tissue kallikreins 7 and 8 in intracranial malignancies显示文摘 | Prezas P Scorilas A Yfanti C | 2006 | Biol Chem2006，387，12： | 1 |
| 12 | Regularized linear method for reconstruction of three-dimensional microscopic objects from optical sections显示文摘 | Preza C Miller M I Thomas J | 1992 | J Opt Soc Am: A1992，9，2： | 1 |
| 13 | Clinical significance of kallikrein- related peptidase 7 (KLK7) in colorectal cancer 显示文摘 | Talieri M Mathioudaki K Prezas P | 2009 | Thromb Haemost2009，101，4： | 1 |
| 14 | Overexpression of the human tissue kallikrein genes KLK4,5,6,and 7 increases the malignant phenotype of ovarian cancer cells显示文摘 | Prezas P Arlt MJ Viktorov P | 2006 | Biol Chem2006，387，6： | 1 |
| 15 | Im-age Reconstruction for 3D light microscopy with a Regularized Linear Method Incorporating a Smoothness Prior显示文摘 | Chrysanthe Preza Michael I Miller Jose-Angel Conchello | 2006 | SPIE2006，905，： | 1 |
| 16 | Depth-variant maximum-likelihood restoration for three-dimensional fluorescence microscopy显示文摘 | Preza C Conchello J A | 2004 | J Opt Soc Am:A2004，21，9： | 1 |
| 17 | Overexpression of the human tissue kallikrein genes KLK4,5,6 and 7 increases the malignant phenotype of ovarian cancer cells显示文摘 | Prezas P Arlt MJ Viktorov P | 2006 | Biol Chem2006，387，6： | 1 |
| 18 | Operating performance and Free Cash Flow of Assets Buyers显示文摘 | Steven Freund Alexandros P Prezas Gopala K Vasudenvas | 2003 | Financial Management2003，，7： | 1 |
| 19 | Theoretical development and experimental evaluation of imaging models for differential-interference-contrast microscopy显示文摘 | Preza C Snyder D L | 1999 | J Opt Soc Am1999，16，9： | 1 |
| 20 | Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells 显示文摘 | Prezas P Arlt M J Viktorov P | 2006 | Biol Chem2006，387，6： | 1 |
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