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30篇 您的检索式:作者名="Prens"
    题名 作者 年代 出处 被引量
1银屑病皮损免疫病理表型特征及其体外维持显示文摘目的 研究银屑病皮损免疫表型及其体外维持。方法 检测代表银屑病病理特征的蛋白分子 ,并观察培养后这些分子的变化。结果 银屑病皮损中角蛋白 16、17、转谷酰酶I、ICAM 1、HLA DR、β1整合素及OKM 5增强表达 ,培养48h后和培养前基本相同。结论 上述蛋白分子的共同表达构成了银屑病皮损的免疫表型 ,这种表型在跨膜皮肤器官模型中 48h培养可得到良好的维持。刘玮 赵庆利 张新华 Reno Debets Errol P Prens 2000中国皮肤性病学杂志2000,14,2:4
2白介素-1β诱导正常人皮肤表达银屑病免疫病理表型显示文摘目的对白介素 -1β(IL 1β)在启动银屑病免疫病理表型中的作用进行研究。方法取健康人正常皮肤在跨膜(transwell)皮肤器官培养模型中进行培养 ,观察在IL 1β或白介素 -1受体拮抗剂(IL 1ra)等细胞因子刺激下 ,培养皮肤表达银屑病免疫病理特征标记物的情况。结果在IL 1β 刺激下 ,正常人皮肤表达了一系列银屑病相关的蛋白分子 ,即角蛋白16、17在表皮棘细胞层强阳性 ;Ⅰ型转谷酰胺酶从表皮颗粒层到棘细胞层过度表达 ;ICAM 1、HLA DR以及β1整合素在表皮基底细胞层和棘细胞层诱导表达或增强表达。培养基中加入IL 1ra可使上述标记物的表达受到显著抑制。培养基中加入抗IL 1β抗体可完全阻断IL 1β的上述诱导作用。结论在培养条件下IL 1β可诱导正常人皮肤表达银屑病的免疫病理表型 ,提示IL 1系统参与了银屑病的皮损形成。刘玮 赵庆利 Reno Debets 蔡瑞康 Errol P Prens 1999中华皮肤科杂志1999,32,2:2
3Non-ablative frac- tional resurfacing in combination with topical tretinoin cream as a field treatment modality for multiple actinic ker- atosis:a pilot study and a review of other field treatment modalities显示文摘Prens SP de Vries K Neumann HA 2013J Dermatolog Treat2013,24,3:1
4The autologous mixed epidermal cell-T lymphocyte reaction is elevated in psoriasis: a crucial role for epidermal HLA-DR+/CD1a--antigen-presenting cells显示文摘Prens E P Benne K Jocst T V 1991J Invest Dermatol1991,96,:1
5Non-ablative fractional resur- facing in combination with topical tretinoin cream as a field treatment modality for multiple actinic keratosis: a pilot study and a review of other field treatment modalities 显示文摘Prens SP Vries KD Neumann HA 2013J Dermatolog Treat2013,24,3:1
6Deroofing: a tissue-saving surgical technique for the treatment of mild to moderate hidradenitis suppurativa lesions显示文摘van der Zee HH Prens EP Boer J 2010J Am Acad Dermatol2010,63,:1
7Purification, potency and immunog- genicity analysis of Vero cell culture-derived rabies vaccine: a comparative study of single-step column chromatography and zonal centrifuge purification 显示文摘Ananda Arone Pren Kumar Kavaratty Raju Mani Chitramb- alam Palaniappan 2005Microbes and Infection2005,89,7:1
8LTCC glass-ceramic composites for microwave application显示文摘Dernovsek O Naeimi A Pren G 2001Eur Ceram Soc2001,21,1011:1
9Unfavorable cardiovascular risk profiles in untreated and treated psoriasis patients显示文摘Wakkee M Thio HB Prens EP 2007Atherosclerosis2007,190,1:1
10Vertex cutsets of undirected graphs显示文摘Patvardhan C Prasad V C and Pren Pyara V 1995IEEE Transactions on Reliability1995,44,2:1
11Effective treatment of psoriasis with narrow-band UVB phototherapy is linked to suppression of the IFN and Thl7 pathways 显示文摘Racz E Prens EP Kurek D 2011J Invest Dermatol2011,131,7:1
12Pathogenesis and pharmacotherapy of Hidradenitis suppurativa显示文摘Nazm7 M van der Zee HH Prens EP 2011Eur J Pharmacol2011,672,13:1
13Effective treatment ofpsoriasis with narrow - band UVB phototherapy is linked to sup- pression of the IFN and Thl7 pathways 显示文摘Prens EP Kurck D Kant M 2011Journal of Investiga- tive Dermatology2011,131,7:1
14Increased expres- sion of interleukin-4 receptors on psoriatic epidermal cells 显示文摘PRENS E HEGMANS J CHIN R 1996Am J Pathoh1996,,148:1
15Effective treatment of psoriasis with narrow-band UVB phototherapy is linked to suppression of the IFN and Thl7 pathways显示文摘Racz E Prens EP Kurek D 2011J Invest Der- matol2011,31,7:1
16Phototherapy and Photochemotherapy for Psoriasis显示文摘Racz E Prens EP 2015Dermatologic Clinics2015,33,1:1
17Pathogenesis and phannacotherapy of Hidradenitis suppurativa 显示文摘Nazary M vander Zee HH Prens EP 2011Eur J Pharmacol2011,672,13:1
18Unfavorable cardiovascular risk profiles in untreated and treated psoriasis patients 显示文摘Wakkee M Thio HB Prens EP 2007Atherosclerosis2007,190,:1
19Effective treatment of psodasis with narrow-band UVB phototherapy is linked to suppression of the IFN and Th 17 pathways显示文摘Ra cz E Prens EP Kurek D 2011J Invest Dermatol2011,131,7:1
20Unfavorable cardiovascular risk profiles in untreated and treated psoriasis patients显示文摘Wakkee M Thio HB Prens EP 0,,01:1
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