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| 1 | Optical disassembly of cellular clusters by tunable ‘tug-of-war’ tweezers显示文摘Bacterial biofilms underlie many persistent infections,posing major hurdles in antibiotic treatment.Here we design and demonstrate‘tug-of-war’optical tweezers that can facilitate the assessment of cell–cell adhesion—a key contributing factor to biofilm development,thanks to the combined actions of optical scattering and gradient forces.With a customized optical landscape distinct from that of conventional tweezers,not only can such‘tug-of-war’tweezers stably trap and stretch a rod-shaped bacterium in the observing plane,but,more importantly,they can also impose a tunable lateral force that pulls apart cellular clusters without any tethering or mechanical movement.As a proof of principle,we examined a Sinorhizobium meliloti strain that forms robust biofilms and found that the strength of intercellular adhesion depends on the growth medium.This technique may herald new photonic tools for optical manipulation and biofilm study,as well as other biological applications. | Anna S Bezryadina Daryl C Preece Joseph C Chen Zhigang Chen | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 2 | Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions显示文摘Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as malaria.Over the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes.Here,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions.Specifically,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the cells.This tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient forces.Interestingly,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free hemoglobin.We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations.Our work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis. | Rekha Gautam Yinxiao Xiang Josh Lamstein Yi Liang Anna Bezryadina Guo Liang Tobias Hansson Benjamin Wetzel Daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti Zhigang Chen | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 3 | Optical tug-of-war tweezers:shaping light for dynamic control of bacterial cells(Invited Paper)显示文摘We design and demonstrate new types of optical tweezers with lateral pulling forces that allow full control of biological samples with complex geometric shapes.With appropriate beam shaping,the dual tug-of-war tweezers effectively hold and stretch elongated biological objects of different sizes,and the triangular tug-of-war tweezers with threefold rotational symmetry steadily hold asymmetric objects in the plane of observation and exert stretching forces along three directions.We successfully apply these tweezers to manipulate microparticles and bacterial cells in aqueous media. | Joshua Lamstein Anna Bezryadina Daryl Preece Joseph C. Chen Zhigang Chen | 2017 | Chinese Optics Letters2017，15，3： | 2 |
| 4 | A study of detnation timing and fragmentation using 3-D finite element techniques and a damage constitutive model 显示文摘 | Thorne B J | 1996 | Proc Int Symp on Fragmentation by Blasting1996，，5： | 1 |
| 5 | Gas and liquid chromatography coupled to tandem mass spectrometry for themultiresidue analysis of β-agonists in biologicalmatrices显示文摘 | VYNCHT GV PREECE S GASPAR P | 1996 | Journal of Chromatogr A1996，，750： | 1 |
| 6 | A multilevel anal- ysis of sociability, usability, and community dy- namics in an online health community显示文摘 | Maloney-Krichmar D Preece J | 2005 | ACM Transactions on Computer-Human Interaction (TOCHI)2005，12，2： | 1 |
| 7 | Activity identification using body-mounted sensors-a review of classification techniques显示文摘 | Preece J S Goulermas Y J Kenney P J L | | 0，，04： | 1 |
| 8 | Intracranial neurenteric cysts : Imaging and pathology spectrum 显示文摘 | Preece MT Osbom AG Chin SS | 2006 | AJNR2006，27，： | 1 |
| 9 | The top five reasons for lurking: improving community experiences for everyone 显示文摘 | PREECE J NONNECKE B ANDREWS D | 2004 | Computers in human behavior2004，20，2： | 1 |
| 10 | Exudation and explant establishment显示文摘 | Comptom M E Preece J E | 1986 | Intl Assoc Plant Culture Neusl1986，50，： | 1 |
| 11 | Body mass index refer- ence curves for the UK, 1990显示文摘 | COLE TJ FREEMAN JV PREECE MA | 1995 | Arch Dis Child1995，73，1： | 1 |
| 12 | Size and strength distributions of melamine-formaldehyde microcapsules prepared by membrane emulsification显示文摘 | Pan X York D Preece J A | 2012 | Powder Technology2012，227，： | 1 |
| 13 | Thidiazuron: A potent cytokinin for woody culture显示文摘 | Huetteman C A Preece J E | 1993 | Plant Cell Tiss Organ Cult1993，33，2： | 1 |
| 14 | Designing for Scalability in a Knowledge Fusion System 显示文摘 | Preece A D Hui K Y Gray W A | 2001 | Knowledge Based Systems2001，14，3： | 1 |
| 15 | Intracranial cysts:radiologic-pathologic correlation and imaging approach显示文摘 | Osbom AG Preece M | | 0，，03： | 1 |
| 16 | Paradox - breaking RAF inhibitors that also target SRC are effective in drug - resistant BRAF mutant melanoma显示文摘 | Girotti MR Lopes F Preece N | 2015 | Cancer Ce112015，27，1： | 1 |
| 17 | Positional influence on rooting of shoots forced from the main bole of swamp white oak and northern red oak显示文摘 | Fishel D W Zaezek J J Preece J E | 2003 | Canadian Journal of Forest Research2003，33，4： | 1 |
| 18 | Intracranial cysts : radiologic- pathologic correlation and imaging approach显示文摘 | Osborn AG Preece MT | 2006 | Radiology2006，239，： | 1 |
| 19 | Designing for Scalability in a Knowledge Fusion System 显示文摘 | Preece A D Hui K Y Gray W A | 2001 | Knowledge Based Systems2001，，34： | 1 |
| 20 | KRAFT: An Agent Architecture for Knowledge Fusion 显示文摘 | Preece A D Hui K Y Gray W A | 2001 | International Journal of Cooperative Information System2001，，12： | 1 |
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