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| 1 | Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients显示文摘BACKGROUND Liver cirrhosis is the late stage of hepatic fibrosis and is characterized by portal hypertension that can clinically lead to decompensation in the form of ascites,esophageal/gastric varices or encephalopathy.The most common sequelae associated with liver cirrhosis are neurologic and neuropsychiatric impairments labeled as hepatic encephalopathy(HE).Well established triggers for HE include infection,gastrointestinal bleeding,constipation,and medications.Alterations to the gut microbiome is one of the leading ammonia producers in the body,and therefore may make patients more susceptible to HE.AIM To investigate the relationship between the use of proton pump inhibitors(PPIs)and HE in patients with cirrhosis.METHODS This is a single center,retrospective analysis.Patients were included in the study with an admitting diagnosis of HE.The degree of HE was determined from subjective and objective portions of hospital admission notes using the West Haven Criteria.The primary outcome of the study was to evaluate the grade of HE in PPI users versus non-users at admission to the hospital and throughout their hospital course.Secondary outcomes included rate of infection,gastrointestinal bleeding within the last 12 mo,mean ammonia level,and model for end-stage liver disease scores at admission.RESULTS The HE grade at admission using the West Haven Criteria was 2.3 in the PPI group compared to 1.7 in the PPI nonuser group(P=0.001).The average length of hospital stay in PPI group was 8.3 d compared to 6.5 d in PPI nonusers(P=0.046).Twenty-seven(31.8%)patients in the PPI user group required an Intensive Care Unit admission during their hospital course compared to 6 in the PPI nonuser group(16.7%)(P=0.138).Finally,10(11.8%)patients in the PPI group expired during their hospital stay compared to 1 in the PPI nonuser group(2.8%)(P=0.220).CONCLUSION Chronic PPI use in cirrhotic patients is associated with significantly higher average West Haven Criteria for HE compared to patients that do not use PPIs. | Matthew Fasullo Prashanth Rau Dong-Qi Liu Erik Holzwanger Jomol P Mathew Yurima Guilarte-Walker Gyongyi Szabo | 2019 | World Journal of Hepatology2019，11，6： | 4 |
| 2 | An in vitro evaluation of pH variations in calcium hydroxide liners显示文摘 | Subramaniam P Konde S Prashanth P | 2006 | J Indian Soc Pedod Prey Dent2006，24，3： | 1 |
| 3 | Oxidation of sulfur dioxide to sulfur trioxide over supported vanadia eata- lysts显示文摘 | Joseph P D Prashanth R K Harvey G S | 1998 | Applied Catalysis B1998，19，2： | 1 |
| 4 | Ther- mal and electrical properties of rare-earth co-doped ceria ce- ramics 显示文摘 | Prashanth Kumar V Reddy Y S Kistaiah P | 2008 | Mater Chem Phys2008，112，2： | 1 |
| 5 | Effect of long term and intensive endurance training in athletes on the age relat- ed decline in left and fight ventricular diastolic function as as- sessed by Doppler echocardiography显示文摘 | Mukhaini M Prashanth P Abdulrehman S | 2009 | Am J Cardiol2009，104，8： | 1 |
| 6 | The Role of Emotions in Marketing 显示文摘 | Richard P Bagozzi Mahesh Gopinath Prashanth U Nyer | 1999 | Academy of Marketing Science1999，27，2： | 1 |
| 7 | lsolation,structural elucidation and immunomodulatory activity of fructans from aged garlic extract显示文摘 | Chandrashekar P M Prashanth K V H Venkatesh Y P | | 0，，2： | 1 |
| 8 | Pozzolanie fly ash as a hydraulic barrier in land fills显示文摘 | Prashanth J P Sivapullaiah P V Sridharan A | 2001 | Engineering Geology2001，6004，： | 1 |
| 9 | Isolation, structural elucidation and immunomodulatory activity of fructans from aged garlic extract显示文摘 | CHANDRASHEKAR P M PRASHANTH K V H VENKATESH Y P | 2011 | Phytochemistry2011，72，： | 1 |
| 10 | High frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation in preterm neonates with hyaline membrane disease: a randomized controlled trial显示文摘 | Singh S N Malik G K Prashanth G P | 2012 | Indian Pediatr2012，49，5： | 1 |
| 11 | Treatment of orange I1 azo-dye by electrocoagulation (EC) technique in a continuous flow cell using sacrificial iron electrodes 显示文摘 | Mohammad Y A M Saurabh R P Prashanth K P | 2004 | Journal of Hazardous Materials2004，109，123： | 1 |
| 12 | Oxidation of sulfur dioxide to sulfur trioxide over supported vanadia catalysts 显示文摘 | Joseph P D Prashanth R K Harvey G S | 1998 | Applied Catalysis B1998，19，2： | 1 |
| 13 | Intramyocardial dissecting haematoma causing cardiac tamponade:An unusual complication after mitral valve replacement surgery显示文摘 | Prashanth P Mukhaini M Maddali MM | 2009 | Ann Card Anaesth2009，12，1： | 1 |
| 14 | Comparative evaluation of pain, tenderness and swelling followed by radiographic evaluation of periapical changes at various intervals of time following single and multiple visit endodontic therapy: an in vivo study显示文摘 | Prashanth M B Tavane P N Abraham S | 2011 | J Contemp Dent Pract2011，12，3： | 1 |
| 15 | Pozzolanic Fly Ash as a Hydraulic Barrier in Land Fills显示文摘 | Sivapullaiah P V Sridharan A | 2001 | Engineering Geology2001，60，： | 1 |
| 16 | Technical note reactive silica and strength of fly ashes 显示文摘 | SIVAPULLAIAH P V PRASHANTH J P SRIDHARAN A | 1998 | Geotechnical and Geological Engineering1998，16，3： | 1 |
| 17 | Oxidation of sulfur dioxide to sulfur trioxide over supported vanadia catalysts显示文摘 | Joseph P D Prashanth R K Harvey G S | 1998 | Applied Catalysis B1998，19，2： | 1 |
| 18 | Treatment of orange Ⅱ azo-dye by electrocoagulation (EC) technique in a continuous flow cell using sacrificial iron electrodes显示文摘 | Mohammad Y A M Saurabh R P Prashanth K P | 2004 | Journal of Hazardous Materials B2004，，109： | 1 |
| 19 | Oxidation of sulfur dioxide to sulfur trioxide over supported vanadia catalysts显示文摘 | Joseph P D Prashanth R K Harvey G S | 1998 | Applied Catalysis B1998，19，： | 1 |
| 20 | Pozzolanic Fly Ash as a Hydraulic Barrier in Landfills显示文摘 | Sivapullaiah P V Sridharan A | 2002 | Engineering Geology2002，60，14： | 1 |
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