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| 1 | Pathogenesis of glomerular haematuria显示文摘Haematuria was known as a benign hallmark of some glomerular diseases, but over the last decade, new evidences pointed its negative implications on kidney disease progression. Cytotoxic effects of oxidative stress induced by hemoglobin, heme, or iron released from red blood cells may account for the tubular injury observed in human biopsy specimens. However, the precise mechanisms responsible for haematuria remain unclear. The presence of red blood cells(RBCs) with irregular contours and shape in the urine indicates RBCs egression from the glomerular capillary into the urinary space. Therefore glomerular haematuria may be a marker of glomerular filtration barrier dysfunction or damage. In this review we describe some key issues regarding epidemiology and pathogenesis of haematuric diseases as well as their renal morphological findings. | Claudia Yuste Eduardo Gutierrez Angel Manuel Sevillano Alfonso Rubio-Navarro Juan Manuel Amaro-Villalobos Alberto Ortiz Jesus Egido Manuel Praga Juan Antonio Moreno | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 2 | Intracellular biosynthesis of Au and Ag nanoparticles using ethanolic extract of Brassica oleracea L. and studies on their physicochemical and biological properties显示文摘In this present study, we reported broccoli(Brassica oleracea L.) as a potential candidate for the synthesis of gold and silver nanoparticles(NPs) in green chemistry method. The synthesized metal nanoparticles are evaluated their antimicrobial efficacy against different human pathogenic organisms. The physico-chemical properties of gold nanoparticles were analyzed using different analytical techniques such as a UV–Vis spectrophotometer, Field Emission Scanning Electron Microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction and a Fourier Transform Infrared spectrophotometer. In addition, gold and silver NP antimicrobial efficacy was checked by disc diffusion assay. UV–Vis color intensity of the nanoparticles was shown at 540 and 450 nm for gold and silver nanoparticles respectively. Higher magnification of the Field Emission Scanning Electron Microscopy image shows the variable morphology of the gold nanoparticles such as spherical, rod and triangular shapes and silver nanoparticles were seen in spherical shapes. The average spherical size of the particles was observed in 24–38 nm for gold and 30–45 nm for silver NPs. X-ray diffraction pattern confirmed the presence of gold nanoparticles and silver nanoparticles which were crystalline in nature. Additionally,the functional metabolites were identified by the Fourier Transform Infrared spectroscopy. IR spectra revealed phenols, alcohols, aldehydes(sugar moieties), vitamins and proteins are present in the broccoli extract which are accountable to synthesize the nanoparticles. The synthesized gold and silver NPs inhibited the growth of the tested bacterial and fungal pathogens at the concentration of 50 μg/m L respectively. In addition, broccoli mediated gold and silver nanoparticles have shown potent antimicrobial activity against human pathogens. | Palaniselvam Kuppusamy Solachuddin J.A.Ichwan Narasimha Reddy Parine Mashitah M.Yusoff Gaanty Pragas Maniam Natanamurugaraj Govindan | 2015 | Journal of Environmental Sciences2015，27，3： | 3 |
| 3 | Nutraceuticals as potential therapeutic agents for colon cancer: a review显示文摘Colon cancer is a world-wide health problem and the second-most dangerous type of cancer,affecting both men and women.The modern diet and lifestyles,with high meat consumption and excessive alcohol use,along with limited physical activity has led to an increasing mortality rate for colon cancer worldwide.As a result,there is a need to develop novel and environmentally benign drug therapies for colon cancer.Currently,nutraceuticals play an increasingly important role in the treatment of various chronic diseases such as colon cancer,diabetes and Alzheimer's disease.Nutraceuticals are derived from various natural sources such as medicinal plants,marine organisms,vegetables and fruits.Nutraceuticals have shown the potential to reduce the risk of colon cancer and slow its progression.These dietary substances target different molecular aspects of colon cancer development.Accordingly,this review briefly discusses the medicinal importance of nutraceuticals and their ability to reduce the risk of colorectal carcinogenesis. | Palaniselvam Kuppusamy Mashitah M.Yusoff Gaanty Pragas Maniam Solachuddin Jauhari Arief Ichwan Ilavenil Soundharrajan Natanamurugaraj Govindan | 2014 | Acta Pharmaceutica Sinica B2014，4，3： | 2 |
| 4 | Matrix metalloproteinase inhibitors显示文摘 | Wojtowicz Praga SM Dickson RB Hawkins MJ | 1997 | Invest New Drugs1997，15，： | 1 |
| 5 | Eradication of Helicobacter pylori be 7-day triple-therapy regimens combining pantoprazole with clarithromycin,metronidazole,or amoxicinllin in patients with peptic ulcer disease:Results of two double-blind,randomized studies显示文摘 | Bochenek WJ Peters S Praga PD | 2003 | Heloicobacter2003，8，： | 1 |
| 6 | Tacrolimus monotherapy in membranous nephropathy:a randomized controlled trial显示文摘 | Praga M Barrio V Juarez GF | 2007 | Kidney Int2007，71，9： | 1 |
| 7 | Renal damage associated with proteinuria 显示文摘 | Praga M Morales E | 2002 | Kidney Int Suppl2002，，82： | 1 |
| 8 | Successful treatment of membranous glomerulonephritis with rituximab in calcineurin inhibitor-dependent patients显示文摘 | SEGARRA A PRAGA M RAMOS N | 2009 | Clin J Am Soc Nephrol2009，4，6： | 1 |
| 9 | Successful treatment of membranous glomerulonephritis with rituximab in calcineurin inhibitor-dependent patients显示文摘 | Segarra A Praga M Ramos N | 2009 | Clin J Am Soc Nephrol2009，4，6： | 1 |
| 10 | Chronic kidney disease as a situation of high added risk in hypertensive patients显示文摘 | Segura J Garcia-Donaire J A Praga M | 2006 | Jam Soc Nephrol2006，17，2： | 1 |
| 11 | Phase I trial of a novel matrix metallopreteinase inhibitor batimastat (BB-94)in patients with advanced cancer显示文摘 | Wojtowicz Praga S Low J Marshall J | 1996 | Invest New Drugs1996，14，2： | 1 |
| 12 | Matrix metalloproteinase inhibitors显示文摘 | Wojtowicz - Praga SM Dickson RB Hawkins MI | 1997 | Invest New Drugs1997，15，1： | 1 |
| 13 | A new heterogeneous acid catalyst for esterification: Optimization using response surface methodology显示文摘 | Peng-Lim Boey Shangeetha Ganesan Gaanty Pragas Maniam Melati Khairuddean Jon Efendi | 2013 | Energy Conversion and Management2013，，： | 1 |
| 14 | Obesity - related renal damage: changing diet to avoid progression 显示文摘 | Praga M Morales E | 2010 | Kidney lnt2010，78，7： | 1 |
| 15 | Therapeutic measures in proteinuric nephropathy显示文摘 | Praga M | 2005 | Kidney Int Suppl2005，，99： | 1 |
| 16 | Persistent microhaematuria with negativeorlowproteinuria显示文摘 | Guti~rrez E Praga M Moreno J A | 2014 | Nefrologia2014，34，1： | 1 |
| 17 | Treatment of IgA nephropathy with ACE inhibitors: a randomized and controlled trial显示文摘 | Praga M Gutierrez E Gonzalez E etal | | 0，，： | 1 |
| 18 | Tacrolimus monotherapy in membranous nephropathy: a randomized controlled trial显示文摘 | Praga M Barrio V Juarez G F | 2007 | Kidney Int2007，71，9： | 1 |
| 19 | The reno-protective effect of the dual blockade of the renin angiotensin system(RAS)显示文摘 | Luno J Praga M De Vinusesa SG | 2005 | Curr Pharm Jes2005，11，10： | 1 |
| 20 | The reno-protective effect of the dual blockade of the renin angiotensin system (RAS)显示文摘 | Luno J Praga M de Vinuesa SG | 2005 | Curr Pharm Des2005，11，10： | 1 |
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