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| 1 | Contrast-enhanced and targeted ultrasound显示文摘Ultrasonic imaging is becoming the most popular medical imaging modality,owing to the low price per examination and its safety.However,blood is a poor scatterer of ultrasound waves at clinical diagnostic transmit frequencies.For perfusion imaging,markers have been designed to enhance the contrast in B-mode imaging.These so-called ultrasound contrast agents consist of microscopically small gas bubbles encapsulated in biodegradable shells.In this review,the physical principles of ultrasound contrast agent microbubble behavior and their adjustment for drug delivery including sonoporation are described.Furthermore,an outline of clinical imaging applications of contrast-enhanced ultrasound is given.It is a challenging task to quantify and predict which bubble phenomenon occurs under which acoustic condition,and how these phenomena may be utilized in ultrasonic imaging.Aided by high-speed photography,our improved understanding of encapsulated microbubble behavior will lead to more sophisticated detection and delivery techniques.More sophisticated methods use quantitative approaches to measure the amount and the time course of bolus or reperfusion curves,and have shown great promise in revealing effective tumor responses to anti-angiogenic drugs in humans before tumor shrinkage occurs.These are beginning to be accepted into clinical practice.In the long term,targeted microbubbles for molecular imaging and eventually for directed anti-tumor therapy are expected to be tested. | Michiel Postema Odd Helge Gilja | 2011 | World Journal of Gastroenterology2011，17，1： | 22 |
| 2 | Phase I therapy study with186Re-labeled humanized monoclonal antibody BIWA 4(bivatuzumab)in patients with head and neck squamous cell carcinoma 显示文摘 | BORJESSON P K POSTEMA E J ROOS J C | 2003 | Clin Cancer Res2003，9，2： | 2 |
| 3 | Ageing and Brugada syndrome: considerations and recommendations显示文摘Brugada syndrome is an inherited disease associated with an increased risk of lethal ventricular arrhythmias. Such arrhythmias stem from innate disruptions in cardiac electrophysiology. Typically, such arrhythmias occur in the third or fourth decade of life. However, Brugada syndrome may also affect geriatric patients. In this paper, we focus on the ageing patientwithBrugada syndrome, and specifically, on the interaction between Brugada syndrome and the more usually acquired clinical problems that may occur with increasing age, such as the use of cardiovascular and non-cardiovascular drugs, or the need for surgery. Such common conditionsmay also disrupt cardiac electrophysiology, thereby conferring added risk for Brugada syndrome patients. We present some considerations and recommendations that may serve as guidance to address these complexities. | Pieter G. Postema Hanno L Tan Arthur AM Wilde | 2013 | Journal of Geriatric Cardiology2013，10，1： | 2 |
| 4 | Bcl-x,a bcl-2 reled gene that functions as a dominant regulator of apoptotic cell deth 显示文摘 | Boise LH Gonzalea-Carcia M Postema CE | 1993 | Cell1993，74，4： | 1 |
| 5 | Bcl-x, A Bcl-2-related gene that functions as a dominant regulator of apoptotic cell death 显示文摘 | BOISE L H GONZALEZ-GARCIA M POSTEMA C E | 1993 | Cell1993，74，4： | 1 |
| 6 | Phase I therapy study with ^186Re-labeled humanized monoclonal antibody BIWA 4(bivatuzumab)in patients with head and neck squamous cell carcinoma 显示文摘 | BORJESSON P K POSTEMA E J ROOS J C | 2003 | Clin Cancer Res2003，9，2： | 1 |
| 7 | Tumor diameter and volume assessed by magnetic resonanee imaging in the prediction of outcome for invasive cervical cancer显示文摘 | Wagenaar HC Trimbos B Postema S | 2001 | Gynecoi Oncol2001，82，3： | 1 |
| 8 | bcl- x, abcl - 2 related gene that functions as a dominant regulator of apoptotic cell death 显示文摘 | Boise LH Gonzalez- Carcia M Postema CE | 1993 | Cell1993，74，： | 1 |
| 9 | Primary metatar-salgia:The influence of a custom moulded insole and a rockerbar on plantar pressure显示文摘 | Postema K Burm P E Zande M E | 1998 | Prosthet Orthot Int1998，22，： | 1 |
| 10 | Generation and performance analysis of wideband radar waveforms显示文摘 | POSTEMA G B | 1987 | IEE International Conference Radar1987，36，10： | 1 |
| 11 | Rat striatal cation shifts reflecting hypoxic - ischemic damage can be predicted by on - line impedance measurements 显示文摘 | BOER J KLEIN HC POSTEMA F | 1989 | Stoke1989，20，： | 1 |
| 12 | bcl-x,abcl-2-related gene that functions as a dominant regulator of apoptotic cell death显示文摘 | Boise LH Gonzalez-Garcia M Postema CE | 1993 | Cell1993，74，4： | 1 |
| 13 | Radioimmunodetec- tion and radioimmunotherapy of head and neck cancer 显示文摘 | Bjojesson PK Postema EJ de Bree R | 2004 | Oral Oneol2004，40，8： | 1 |
| 14 | Bcl-x, a bcl-2- regulated gene that functions as dominant regulator of apoptotic cell death 显示文摘 | Boise LH Gonzalez-Garcia M Postema CE | 1993 | Cell1993，74，3： | 1 |
| 15 | Bcl-x,a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death显示文摘 | Boise L H González-García M Postema C E | 1993 | Cell1993，74，： | 1 |
| 16 | Recurrent and founder mutations in the Netherlands : the long-QT syndrome 显示文摘 | Hofman N Jongbloed R Postema PG | 2011 | Nether- lands Heart Jouma12011，19，： | 1 |
| 17 | Generation and Performance Analysis of Wideband Radar Waveforms显示文摘 | | 1987 | IEE International Conference Radar1987，，： | 1 |
| 18 | Final results of a phase Ⅰ radioimmunotherapy trial using (186) Re-epratuzumab for the treatment of patients with non-Hodgkin's lymphoma显示文摘 | Postema EJ Raemaekers JM Oyen WJ | 2003 | Clin Cancer Res2003，9，102： | 1 |
| 19 | Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death显示文摘 | Boise LH Gonzalez-Garcia M Postema CE | 1993 | Cell1993，74，4： | 1 |
| 20 | Divergent axon collaterals of rat locus eoeruleus neurons: demonstration by a fluorescent double labeling technique 显示文摘 | Room P Postema F Korf J | 1981 | Brain Res1981，221，2： | 1 |
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