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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Simulation of moving boundary of the reaction shaft in a flash smelting furnace显示文摘As to solve the online monitoring of the inner temperatur e and freezing profile of the reaction shaft of flash smelting furnace, simulation of the wall in the reaction shaft in a flash smelting furnace was made through numerical computation. The computational results are very near the data got in s ite. The error of the moving boundary is approximately 3%, and that of the tempe rature is less than 5%. It is proved that the simulation software is applicable for practice to monitor the temperature and moving boundary inside the hearth on line. Based on a large number of the data computed, the relation between the cha nge of the moving boundary and inner temperature is summarized, and the great in fluence of the cooling system on the forming and stability of the moving boundar y inside the hearth is emphasized, which provide the theoretical bases for optim izing the flash smelting operation. | CHEN Zhuo 1,MEI Chi 1,CHEN Hong-rong 1,MO Jiao 2 (1 Institute on Simulation and Optimization of Pyro-installation, Central Sout h University, Changsha 410083, China 2 Science School, Beijing University of Posts and Telecommunications, Beijing 1 | 2001 | Journal of Central South University2001，13，3： | 3 |
| 3 | S3-Leitlinie Kolorektales Karzinom Version 1.0 - Juni 2013 AWMF-Registernummer: 021/007OL显示文摘 | C. Pox S. Aretz S. Bischoff U. Graeven M. Hass P. Heu?ner W. Hohenberger A. Holstege J. Hübner F. Kolligs M. Kreis P. Lux J. Ockenga R. Porschen S. Post N. Rahner A. Reinacher-Schick J. Riemann R. Sauer A. Sieg W. Scheppach W. Schmitt H. Schmoll K. Schulm | 2013 | Z Gastroenterol2013，，08： | 2 |
| 4 | Relation between properties and performance of zeolites in paraffin cracking显示文摘 | Wielers A F H Vaarkamp M Post M F M | 1991 | Journal of Catalysis1991，127，1： | 1 |
| 5 | Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer:a randomized controlled trlal显示文摘 | Oettle H Post S Neuhaus P | 2007 | JAMA2007，297，3： | 1 |
| 6 | Fibrates suppress bile acid synthesis via peroxisome proliferator -activated receptor -alpha -mediated downregulation of cholesterol 7alpha - hydroxylase and sterol 27 - hydroxylase expression显示文摘 | Post SM Duez H Gervois PP | 2001 | Arterioscler Thromb Vasc Biol2001，21，11： | 1 |
| 7 | Weight-bearing activity during youth is a more important factor for peak bone mass than calcium intake显示文摘 | Welten D C Kemper H C Post G B | 1994 | J Bone Miner Res1994，9，7： | 1 |
| 8 | Relation between properties and performance of zeolites in paraffin cracking显示文摘 | WIELERS A F H VAARKAMP M POST M F M | 1991 | J Catal1991，127，1： | 1 |
| 9 | X-ray diffraction study of crystalline neopentane (tetramethyl methane)显示文摘 | MONES A H POST B | 1952 | J Chem Phys1952，20，4： | 1 |
| 10 | Development and validation of a short version of the Stroke Specific Quality of Life Scale 显示文摘 | Post MW Boosman H van Zandvoort MM | 2011 | J Neurol Neruosurg Psychiatry2011，，82： | 1 |
| 11 | Differential ofects of 17aethinylestradiol on the neutral and acidic pathways of bile saltsynthesis in the rat显示文摘 | Post SM Wolters H | 1999 | J Lipid Res1999，40，： | 1 |
| 12 | Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial显示文摘 | Oettle H Post S Neuhaus P | 2007 | JAMA2007，297，3： | 1 |
| 13 | Role of oxidants/inflam- mation in declining renal function in chronic kidney disease and nor- mal aging显示文摘 | Vlassara H Torreggiani M Post J B | 2009 | Kidney Int Suppl2009，，114： | 1 |
| 14 | Low water contents in pyroxenes from spinel-peridotites of the oxidized,sub-arc mantle wedge显示文摘 | Peslier A H Luhr J F Post J | 2002 | Earth Plan Sc Lett2002，201，： | 1 |
| 15 | The global carbon cycle显示文摘 | Post W M Peng T H Emanuel W R | 1990 | American Scientist1990，78，： | 1 |
| 16 | The 2007 eastern US springfreeze:increased cold damage in a warming world?显示文摘 | GU L H HANSON P J POST W M | 2008 | Bioscience2008，58，3： | 1 |
| 17 | A missense mutation in the second transmembrane segment of the luteinizing hormone receptor causes familial male- limited precocious puberty显示文摘 | Kraaij R Post M Kremer H | 1995 | J Clin Endocrinol Metab1995，80，11： | 1 |
| 18 | Changes in long- term no-till corn growth and yield under different rates of stover mulch显示文摘 | Blaneo-Canqui H Lal R Post W M | 2006 | AgroJ2006，98，4： | 1 |
| 19 | Standard methods for land-use planning to determine the effects on societal risk显示文摘 | LAHEIJ G M H POST J G ALE B J M | 2000 | Journal of Hazardous Materials2000，71，1： | 1 |
| 20 | Offshore fresh groundwater reserves as a global phenomenon显示文摘 | POST V E A GROEN J KOOI H | 2013 | Nature2013，504，7478： | 1 |
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