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| 1 | Protein expression by Aeromonas hydrophila during growth in vitro and in vivo 显示文摘 | Poobalane S Thompson K D Diab A | 2008 | Microbial Pathogenesis2008，45，1： | 1 |
| 2 | Effects of weight loss in overweight/obese individuals and long-term hypertension outcomes: a systematic review显示文摘 | Aucott L Poobalan A Smith WC | 2005 | Hypertension2005，45，6： | 1 |
| 3 | Effects of weight loss in overweight/ obese individuals and long-term hypertension outcomes: a systematic review 显示文摘 | Aucott L Poobalan A Smith WC | 2005 | Hypertension2005，45，： | 1 |
| 4 | Glycated haemoglobin reduction and fixed ratio combinations of analogue basal insulin and glucagon-like peptide-1 receptor agonists:A systematic review显示文摘BACKGROUND Fixed ratio combinations(FRCs)of analogue basal insulin and glucagon-like peptide-1 receptor agonists are a newer addition to the therapeutic armamentarium for the management of type 2 diabetes mellitus.They reduce treatment complexity by combining two injectables in a single daily injectable,thus potentially improving adherence and persistence.Clinicians wanting to use FRCs would need to choose between members of the class.AIM To describe and contrast the glycated haemoglobin reduction of two FRCs of analogue basal insulin and glucagon like peptide-1 receptor agonist in adults with type 2 diabetes mellitus.METHODS The following Population,Intervention,Comparison,Outcome question was used for the primary analysis:Among adult patients with type 2 diabetes mellitus[P],what is the effect of iGlarLixi[I]compared to IDegLira[C]for bringing about glycaemic control(as measured by reduction in glycosylated haemoglobin)[O]?The Prisma Statement was used as a guideline for framing this systematic review.We searched PubMed,EMBASE and Cochrane library databases and Clinicaltrials.gov using various keywords and medical search headings related to type 2 diabetes mellitus,iGlarlixi,IDegLira and glycated haemoglobin A1c.RESULTS All 14 studies identified by the systematic search met the primary efficacy endpoint of reduction in glycated haemoglobin.There were no head-to-head studies between the FRCs of iGlarlixi and IDegLira,and we therefore did an indirect comparison based on a common comparator of insulin glargine U100.Both iGlarLixi and IDegLira effectively reduce glycated haemoglobin when compared to insulin glargine U100.However,using indirect comparisons,IDegLira had a greater haemoglobin A1c reducing ability(0.6%vs 0.3%).The indirect comparison is limited by the differences between the studies;the fasting blood glucose targets were slightly higher for iGlarLixi studies when compared to the IDegLira studies(4.0-5.0 mmol/L and 4.4-5.6 mmol/L),and the IDegLira study used a greater average dose of insulin glargine when compared to the iGlarLixi studies(66 U/d vs 40 U/d).CONCLUSION Both iGlarLixi and IDegLira effectively reduce glycated haemoglobin.Indirect comparisons,using insulin glargine as the common comparator,suggest that IDegLira reduces glycated haemoglobin to a greater extent than iGlarLixi.However,given the limitations of indirect comparisons,robust head to head studies and real-world data would better inform clinician choice and clinical practice guidelines. | Poobalan Naidoo Celia Bouharati Virendra Rambiritch Sumanth Karamchand Barbara A Tafuto Rory F Leisegang | 2021 | World Journal of Meta-Analysis2021，9，3： | 1 |
| 5 | Effects of weight loss inoverweight/obese individuals and long - term hypertension outcomes: a systematic review显示文摘 | Aucott L Poobalan A Smith WC | 2005 | Hypertension2005，45，： | 1 |
| 6 | Effects of weight loss in overweight/obese individuals and long-term hypertension outcomes: a systematic review 显示文摘 | AUCOTT L POOBALAN A SMITH W C | 2005 | Hypertension2005，45，6： | 1 |
| 7 | Knowledge, attitude, and prevalence of overweight and obesity among civil servants in Nepal 显示文摘 | Simkhada P Poobalan A Simkhada PP | 2011 | Asia-Pacific Journal of Public Health2011，23，4： | 1 |
| 8 | Effects of weight loss in overweight/obese individuals and long-term hyper-tension outcomes:a systematic review显示文摘 | Aucott L Poobalan A Smith WC | | 0，，06： | 1 |
| 9 | Effects of weight loss in o- verweight/obese individuals and long - term hypertension outcomes: a systematic review 显示文摘 | Aucott L Poobalan A Smith WC | 2005 | Hypertension2005，45，6： | 1 |
| 10 | A review of chronic pain after inguinal herniorrhaphy显示文摘 | Poobalan A S Bruce J Smith W C | 2003 | Clin J Pain2003，19，1： | 1 |
| 11 | Obesity as an independent risk factor for elective and emergency caesarean delivery in nulliparous women-systematic review and meta-analysis of cohort studies显示文摘 | Poobalan A S Aucott L S Gurung T | 2009 | Obes Rev2009，10，1： | 1 |
| 12 | Effects of weight loss in overweight/ obese individuals and long-term hypertension outcomes: a systematic review 显示文摘 | Aucott L Poobalan A Smith WC | 2005 | Hypertensian2005，45，6： | 1 |
| 13 | Knowledge, attitude, and prevalence of overweight and obesity among civil servants in Nepal 显示文摘 | Simkhada P Poobalan A Simkhada PP | 2011 | Asia Pac J Public Health2011，23，4： | 1 |
| 14 | Weight loss in obese diabetic and non-diabetic individuals and long-term diabetes outcomes:a systematic review显示文摘 | AUCOTT L POOBALAN A SMITH W C | 2004 | Diabetes Obesity and Metabolism2004，6，2： | 1 |
| 15 | Effects of Weight Loss in Overweight/Obese Individuals and Long-Term Hypertension Outcomes:A Systematic Review显示文摘 | Aucott L Poobalan A Carins WS | | 0，，06： | 1 |
| 16 | Protein expression by Aeromonas hydrophila during growth in vitro and in vivo 显示文摘 | POOBALANE S THOMPSON K D DIAB A | 2008 | Microbial Pathogenesis2008，45，1： | 1 |
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