|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Composition and structural features of cell wall polysaccharides fromtomato fruits显示文摘 | SEYMOUR G B COLQUHOUN I J Du PONT M S | 1990 | Phytochemistry1990，29，3： | 1 |
| 3 | The effect of colchicine on liver function tests and hepatic fibrosis in patients with chronic active hepatitis:a study of 3 cases(author's transl)显示文摘 | Leandro P Ade O e Silva A BrandSo J F Saldanha L B Pontes J F | 2013 | Arquivos de Gastroenterologia2013，15，3： | 1 |
| 4 | Storage temperature effect on histamine formation in big eye tuna and skipjack显示文摘 | SILVA C C G da PONTE D J B DAPKEVICIUS M L N | 1998 | Journal of Food Science1998，63，4： | 1 |
| 5 | Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney in- jury requiring continuous renal replacement therapy: a randomized controlled trial显示文摘 | Stucker F Ponte B Tataw J | 2015 | Crit Care2015，19，1： | 1 |
| 6 | Anaesthetic temperature and shivering in epidural anaesthesia 显示文摘 | PONTE J COLLETT B J WALMSLEY A | 1986 | Acta Anaesthesiol Scand1986，30，7： | 1 |
| 7 | Application of dempster-shafer theory in condition monitoring systems:a case study显示文摘 | Parikh C R Pont M J Jones N B | 2003 | Pattem Recognition Letters2003，22，67： | 1 |
| 8 | Application of dempster-shafer theory in condition monitoring systems: a case study 显示文摘 | Parikh C R Pont M J Jones N B | 2003 | Pattern Recognition Letters2003，22，： | 1 |
| 9 | Interactions of captopril and verapamil on glucose tolerance and insulin action in an animal model of insulin resistance显示文摘 | Dal Ponte D B Fogt D L Jacob S | 1998 | Metabolism1998，47，： | 1 |
| 10 | Sensitivity analysis of envi- ronmental changes associated with riverscape evolutions follow- ing sediment reintroduction: geomatic approach on the Dr6me River network, France显示文摘 | M61anie B Pi6gay H Pont D | 2013 | International Journal of River Basin Management2013，11，1： | 1 |
| 11 | Development and validation of a fish-based index for the assessment of 'river health' in France显示文摘 | Oberdorff T Pont D Hugueny B | 2002 | Freshwater Biology2002，47，9： | 1 |
| 12 | Application of dempster-shafer theory in condition monitoring systems: a case study 显示文摘 | PARIKH C R PONT M J JONES N B | 2003 | Pattern Recognition Letters2003，22，2： | 1 |
| 13 | Classification of distilled alcoholic beverages and verification of adulteration by near infrared spectrometry显示文摘 | Pontes M J C Santos S R B Araujo M C U | 2006 | Food Research International2006，39，： | 1 |
| 14 | Development and validation of a fish-based index for the assessment of ' river health' in France显示文摘 | Oberdorff T Pont D hugueny B | 2002 | Freshwater Biology2002，47，9： | 1 |
| 15 | Not all inflammatory markers are linked to kidney function:results from a populationbased study显示文摘 | Pruijm M Ponte B Vollenweider P | 2012 | Am J Nephrol2012，35，3： | 1 |
| 16 | Oto- mycosis:a retrospective study显示文摘 | PONTES Z B SILVA A D LIMA EDE O | 2009 | Braz J Otorhinolar- yngol2009，75，： | 1 |
| 17 | The cleveland clinic experience with adrenal cortical carcinoma显示文摘 | Bodie B Novick AC Pontes JE | 1989 | J Urol1989，141，： | 1 |
| 18 | Reference values and factors associated with renal resistive index in a family-based population study显示文摘 | Ponte B Pruijm M Ackermann D | 2014 | Hypertension2014，63，： | 1 |
| 19 | Application of Dempster-shafer Theory in Condition Monitoring Systems: a Case Study显示文摘 | Parikh C R Pont M J Jones N B | 2003 | Pattern Recognition Letters2003，22，6： | 1 |
| 20 | Making patient-centered care come alive:achieving full integration of the patient's perspective显示文摘 | Ponte P R Conlin G Conway J B | 2003 | J Nurs Adm2003，33，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员