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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | Intestinal preparation prior to capsule endoscopy administration显示文摘In order to have an adequate view of the whole small intestine during capsule endoscopy, the preparation recommended consists of a clear liquid diet and an overnight fast. However, visualization of the small bowel during video capsule endoscopy can be impaired by intestinal contents. To improve mucosal visualization, some authors have evaluated different regimens of preparation. There is no consensus about the necessity of intestinal preparation for capsule endoscopy and it should be interesting to develop adequate guidelines to improve its efficacy and tolerability. Moreover, the effect of preparation type (purgative) on intestinal transit time is not clear. Since a bowel preparation cannot defini-tively improve its visibility (and theoretically the yield of the test), it is not routinely recommended. | Vicente Pons Beltrán Cristina Carretero Begoa Gonzalez-Suárez Iaqui Fernández-Urien Miguel Muoz-Navas | 2008 | World Journal of Gastroenterology2008，14，37： | 5 |
| 3 | Tolerance in liver transplantation: Biomarkers and clinical relevance显示文摘Transplantation is the optimal treatment for end-stage organ failure,and modern immunosuppression has allowed important progress in short-term outcomes. However,immunosuppression poorly influences chronic rejection and elicits chronic toxicity in current clinical practice. Thus,a major goal in transplantation is to understand and induce tolerance. It is well established that human regulatory T cells expressing the transcription factor Fox P3 play important roles in the maintenance of immunological self-tolerance and immune homeostasis. The major regulatory T cell subsets and mechanisms of expansion that are critical for induction and long-term maintenance of graft tolerance and survival are being actively investigated. Likewise,other immune cells,such as dendritic cells,monocyte/macrophages or natural killer cells,have been described as part of the process known as 'operational tolerance'. However,translation of these results towards clinical practice needs solid tools to identify accurately and reliably patients who are going to be tolerant. In this way,a plethora of genetic and cellular biomarkers is raising and being validated worldwide in large multicenter clinical trials. Few of the studies performed so far have provided a detailed analysis of the impact of immunosuppression withdrawal on pre-existing complications derived from the long-term administration of immunosuppressive drugs and the side effects associated with them. The future of liver transplantation is aimed to develop new therapies which increase the actual low tolerant vs non-tolerant recipients ratio. | Alberto Baroja-Mazo Beatriz Revilla-Nuin Pascual Parrilla Laura Martínez-Alarcón Pablo Ramírez José Antonio Pons | 2016 | World Journal of Gastroenterology2016，22，34： | 4 |
| 4 | A novel motion tracking system for evaluation of functional rehabilitation of the upper limbs显示文摘Upper limb function impairment is one of the most common sequelae of central nervous system injury, especially in stroke patients and when spinal cord injury produces tetraplegia. Conventional assessment methods cannot provide objective evaluation of patient performance and the effectiveness of therapies. The most common assessment tools are based on rating scales, which are inefficient when measuring small changes and can yield subjective bias. In this study, we designed an inertial sensor-based monitoring system composed of five sensors to measure and analyze the complex movements of the upper limbs, which are common in activities of daily living. We developed a kinematic model with nine degrees of freedom to analyze upper limb and head movements in three dimensions. This system was then validated using a commercial optoelectronic system. These findings suggest that an inertial sensor-based motion tracking system can be used in patients who have upper limb impairment through data integration with a virtual reality-based neurorehabilitation system. | ngel Gil-Agudo Ana de los Reyes-Guzmán Iris Dimbwadyo-Terrer Benito Peasco-Martín Alberto Bernal-Sahún Patricia López-Monteagudo Antonio del Ama-Espinosa José Luis Pons | 2013 | Neural Regeneration Research2013，8，19： | 3 |
| 5 | Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?显示文摘AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact. METHODS: One hundred patients with an indication for capsule endoscopy were included in the study. All procedures were performed with the new device(SB24). After an exhaustive evaluation of the SB24 videos, they were then converted to 'SB2-like' videos for their evaluation. Findings, frames per finding, and clinical and therapeutic impact derived from video visualization were analyzed. Kappa index for interobserver agreement and χ2 and Student's t tests for qualitative/quantitative variables, respectively, were used. Values of P under 0.05 were considered statistically significant.RESULTS: Eighty-nine out of 100 cases included in the study were ultimately included in the analysis. The SB24 videos detected the anatomical landmarks(Zline and duodenal papilla) and lesions in more patients than the 'SB2-like' videos. On the other hand, the SB24 videos detected more frames per landmark/lesion than the 'SB2-like' videos. However, these differences were not statistically significant(P > 0.05). Both clinical and therapeutic impacts were similar between SB24 and 'SB2-like' videos(K = 0.954). The time spent by readers was significantly higher for SB24 videos visualization(P < 0.05) than for 'SB2-like' videos when all images captured by the capsule were considered. However, these differences become non-significant if we only take into account small bowel images(P > 0.05).CONCLUSION: More frames-per-second detect more landmarks, lesions, and frames per landmark/lesion, but is time consuming and has a very low impact on clinical and therapeutic management. | Ignacio Fernandez-Urien Cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas Vicente Pons Cesar Prieto Julio Valle | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 6 | Small bowel bacterial overgrowth in patients with alcoholic cirrhosis显示文摘 | Dr. F. Casafont Morencos MD G. Heras Casta?o MD L. Martín Ramos MD Maria J. López Arias MD F. Ledesma MD F. Pons Romero MD | 1996 | Digestive Diseases and Sciences1996，，3： | 2 |
| 7 | Blind nasotracheal mtubation for patientswith penetrating neck trauma显示文摘 | Weitzel N Kendall J Pons P | 2004 | J Trauma2004，56，5： | 1 |
| 8 | Using image analy- sis in the study of multiphase gas absorption 显示文摘 | Mena P C Pons M N Teixeira J A | 2005 | Chemi- cal Engineering Science2005，60，18： | 1 |
| 9 | The effect of systemic lupus erythematosus and long-term steroid therapy on bone mass in pre-menopausal women显示文摘 | Peris P Guanabens N | 1995 | Br J Rheumatol1995，34，5： | 1 |
| 10 | Electro-coagula- tion of reactive textile dyes and textile wastewater 显示文摘 | Alinsafi A Khemis M Pons M N | 2005 | Chem Eng Process2005，44，4： | 1 |
| 11 | A rare cause of gastric outlet obstruction:Bouveret's syndrome显示文摘 | Crespo Pérez L Angueira Lape(n)a T Defarges Pons V | 2008 | Gastroenterol Hepatol2008，31，10： | 1 |
| 12 | Photocatalytic degradation of three azo dyes using immobilized TiO2 nanoparticles on glass platesactivated by UV light irradiation:Influence of dye molecular structure显示文摘 | Khataee A R Pons M N Zahraa O | 2009 | Journal of Hazardous Materials2009，168，1： | 1 |
| 13 | Wastewater fingerprinting by UV-visible and synchronous fluorescence spectroscopy显示文摘 | Wu J Pons M N Potier O | 2006 | Water Science and Technology2006，53，45： | 1 |
| 14 | Product Recall Crisis Management: The Impact on Manufacturer's Image, Consumer Loyalty and Purchase Intention 显示文摘 | SOUIDEN N PONS F | 2009 | Journal of Product & Brand Management2009，18，2： | 1 |
| 15 | Melatonin treatment enhances the efficiency of mice immunization with Vnezuelan equine encephalomyelitis virus TC-83 显示文摘 | Negrette B Bonilla E Valero N Pons H Garcia Tamayo J Chacin-Bonilla L | 2001 | Neurochem Res2001，26，7： | 1 |
| 16 | Discoloration of a red cationic dye by supported TiO2 photocatalysis显示文摘 | Mounir B Pons M N Zahraa O | | 0，，03： | 1 |
| 17 | Review Diagnosis Methods of Induction Electrical Machines based on Steady State Current显示文摘 | Rub(e)n Puche Panadero Joan Pons Llinares Vicente Climente Alarcon y Manuel Pineda S(a)nchez | 2009 | l lth Spanish Portuguese Conference On Electrical Engineering2009，，： | 1 |
| 18 | Effect of sustained virological response to treatment on the incidence of abnormal glucose values in chronic hepatitis C显示文摘 | Manuel Romero-Gómez Conrado M. Fernández-Rodríguez Raúl J. Andrade Moisés Diago Sonia Alonso Ramón Planas Ricard Solá José A. Pons Javier Salmerón Rafael Barcena Ramón Perez Isabel Carmona Santiago Durán | 2008 | Journal of Hepatology2008，，5： | 1 |
| 19 | Blind nasotrachcal intubation for patients with penetrating neck lrauma 显示文摘 | Wcitzcl N Kendall J Pons P | 2004 | J Trauma2004，56，5： | 1 |
| 20 | Endogenous processes during long term starvation in activated sludge per- forming enhanced biological phosphorus removal显示文摘 | LOPEZ C PONS M N MORGENROTH E | 2006 | Water Re search2006，40，8： | 1 |
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