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| 1 | Exosomal miRNA profiling before and after surgery revealed potential diagnostic and prognostic markers for lung adenocarcinoma显示文摘Exosome is a crucial manner for cancer cell to cell communication and circulating exosomes sever as promising diagnostic and prognostic markers for various types of diseases.A predominant type of cargo of exosome is small RNAs,especially miRNAs.Here,we profiled plasma exosomal miRNAs of six lung adenocarcinoma patients before and after surgery,as well as six healthy individuals as normal control.Our profiling revealed 38 upregulated and 37 downregulated exosomal miRNAs in the plasma of lung adenocarcinoma patients.Additionally,we found that most upregulated miRNAs were increased in the lung adenocarcinoma samples of TCGA database.We further evaluated the correlation between the upregulated exosomal miRNAs and overall survival with Kaplan-Meier survival analysis using online databases.Our resu ltS suggested that exosomal miR-151a-5p,miR-10b-5p,miR-192-5p,miR-106b-3p,and miR-484 are potential prognostic markers for lung adenocarcinoma.Importantly,we validated candidate miRNAs in lung adenocarcinoma patients before and after surgery as well as in healthy controls and found that miR-484 was significantly increased in the plasma of lung adenocarcinoma patients and strikingly decreased post-surgery.Hence,we provided novel information on lung adenocarcinoma-derived exosomal miRNA and potential non-invasive diagnostic and prognostic markers for lung adenocarcinoma. | Xinying Xue Chen Wang Zhiqiang Xue Jiaxin Wen Jun Han Xidong Ma Xuelei Zang Hui Deng Rui Guo Idorenyin Polycarp Asuquo Chong Qin Haijiao Wang Quansheng Gao Sanhong Liu Jianxin Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 6 |
| 2 | Backstepping-based flight control with adaptive function approximation 显示文摘 | Farrell J Sharma M Polycarpou M | 2005 | Journal of Guidance Control and Dynamics2005，28，6： | 1 |
| 3 | Command filtered backstepping 显示文摘 | FARRELL J A POLYCARPOU M SHARMA M | 2009 | IEEE Transactions on Automatic Control2009，54，6： | 1 |
| 4 | A robust adaptive nonlinear control design显示文摘 | Ioannou P A | 1996 | Automatica1996，32，3： | 1 |
| 5 | Robust nonlinear fault diagnosis in input-output systems 显示文摘 | Vemuri A T Polycarpou M M | 1997 | International Journal of Control1997，68，2： | 1 |
| 6 | Command filtered adaptive backstepping 显示文摘 | DONG W J FARRELL J A POLYCARPOU M M | 2012 | IEEE Transactions on Control Sys- tems Technology2012，20，3： | 1 |
| 7 | Analytical Approximations in Modeling Contacting Rough Surfaces 显示文摘 | Polycarpou A A Etsion I | 1999 | ASME Journal of Tribology1999，121，1： | 1 |
| 8 | Automated fault diagnosis in nonlinear multivariable systems using a learning methodology 显示文摘 | Trunov A B Polycarpou M M | 2000 | IEEE Transactions on Neural Networks2000，11，1： | 1 |
| 9 | Adhesive Contact Based on the Lennard Jones Potential: a Correction to the Value of the Equilibrium Distance as Used in the Potential 显示文摘 | Yu Ning Polycarpou A A | 2004 | Journal of Colloid and Interface Science2004，278，2： | 1 |
| 10 | Fault diagnosis of a class of nonlinear uncertain systems with Lipschitz nonlinearities u- sing adaptive estimation 显示文摘 | Zhang X D Polycarpou M M Parisini P | 2010 | Automatica2010，46，2： | 1 |
| 11 | Robust fault isolation for a class of non-linear input-output systems 显示文摘 | Zhang X D Polycarpou M M Parisini T | 2001 | International Journal of Control2001，74，13： | 1 |
| 12 | A robust adaptive nonlinear control design显示文摘 | Polycarpou M M Ioannou P A | 1996 | Automat ica1996，32，3： | 1 |
| 13 | 显示文摘 | Yu N Pergande S R Polycarpou A | 2004 | J Tribology2004，126，： | 1 |
| 14 | Automated fault detection and accommodation: a learning systems approach显示文摘 | Polycarpou M M Helmicki A J | 1995 | IEEE Trans Systems Man and Cybernetics1995，25，11： | 1 |
| 15 | Neural Networks and On-Line Approximators for Discrete-Time Nonlinear System Identification 显示文摘 | Polycarpou M Ioannou P | 1991 | Preprint1991，，： | 1 |
| 16 | Incipient fault diagnosis of dynamical systems using online approximators 显示文摘 | Demetriou M A Polycarpou M M | 1998 | IEEE Transactions on Automatic Control1998，43，11： | 1 |
| 17 | Longitudinal flight-path control using online function approximation显示文摘 | Farell J A Sharma M Polycarpou M | 2003 | J of Guidance Control and Dynamics2003，26，6： | 1 |
| 18 | Measurement and Modeling of Normal Contact Stiffness and Contact Damping at the Meso Scale显示文摘 | Shi X Polycarpou A A | 2005 | ASME Journal of Vibration and Acoustics2005，127，： | 1 |
| 19 | Sen- sor Bias Fault Isolation in a Class of Nonlinear Systems 显示文摘 | ZHANG X D POLYCARPOU M M PARISINI T | 2005 | IEEE Transactions on Automatic Control2005，50，3： | 1 |
| 20 | Learning approach to nonlinear fault diagnosis: detectability analysis 显示文摘 | Polycarpou M M Trunov A B | 2000 | IEEE Transactions on Automatic Control2000，45，4： | 1 |
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