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| 1 | Role of receptor tyrosine kinases in gastric cancer: New targets for a selective therapy显示文摘受体酷氨酸家族 ases (RTK ) 象表皮的生长因素受体家庭那样包括增长和变形传播参予肿瘤形成的几步。几已知的 RTK 起来在是主要的胃的癌症调整了定制的治疗的目标。仅仅初步的数据然而,在使用上存在当前临床上可得到的药象在胃的癌症的背景的 trastuzumab, cetuximab, bevacizumab, gefitinib, erlotinib,和 imatinib 那样。现出症状之前的潜的数据建议他们的使用的一个潜在的好处,特别在有“常规”的抑制细胞的联合治疗。这评论象新途径和药一样在癌症治疗关于他们的使用总结当前的知识优化治疗成功。 | JC Becker C Müller-Tidow H Serve W Domschke T Pohle | 2006 | World Journal of Gastroenterology2006，12，21： | 19 |
| 2 | Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing显示文摘Helicobacter pylori(H.pylori)infection is highly prevalent in the human population and may lead to severe gastrointestinal pathology including gastric and duodenal ulcers,mucosa associated tissue lymphoma and gastric adenocarcinoma.In recent years,an alarming increase in antimicrobial resistance and subsequently failing empiric H.pylori eradication therapies have been noted worldwide,also in many European countries.Therefore,rapid and accurate determination of H.pylori’s antibiotic susceptibility prior to the administration of eradication regimens becomes ever more important.Traditionally,detection of H.pylori and its antimicrobial resistance is done by culture and phenotypic drug susceptibility testing that are cumbersome with a long turn-around-time.Recent advances in diagnostics provide new tools,like real-time polymerase chain reaction(PCR)and line probe assays,to diagnose H.pylori infection and antimicrobial resistance to certain antibiotics,directly from clinical specimens.Moreover,high-throughput whole genome sequencing technologies allow the rapid analysis of the pathogen’s genome,thereby allowing identification of resistance mutations and associated antibiotic resistance.In the first part of this review,we will give an overview on currently available diagnostic methods for detection of H.pylori and its drug resistance and their implementation in H.pylori management.The second part of the review focusses on the use of next generation sequencing technology in H.pylori research.To this end,we conducted a literature search for original research articles in English using the terms“Helicobacter”,“transcriptomic”,“transcriptome”,“next generation sequencing”and“whole genome sequencing”.This review is aimed to bridge the gap between current diagnostic practice(histology,rapid urease test,H.pylori culture,PCR and line probe assays)and new sequencing technologies and their potential implementation in diagnostic laboratory settings in order to complement the currently recommended H.pylori management guidelines and subsequently improve public health. | Daniel Pohl Peter M Keller Valentine Bordier Karoline Wagner | 2019 | World Journal of Gastroenterology2019，25，32： | 15 |
| 3 | Computerized ann training improves the motor control of the severely affected arm after stroke:a single-blinded randomized trial in two centers显示文摘 | Hesse S Wemer C Pohl M | 2005 | Stroke2005，36，9： | 1 |
| 4 | Computed virtual chromoendoscopy for classification of small colorectal lesions: a prospective comparative study显示文摘 | Pohl J Nguyen-Tat M Pech O | 2008 | Am J Gastroenterol2008，103，3： | 1 |
| 5 | Comparison of stimulation with clomiphene citrate in combination with recombinant follicle-stimulating hormone and recombinant luteinizing hormone to stimulation with a gonadotropin-releasing hormone agonist protocol: a prospective randomized study 显示文摘 | Weigert M Krischker U Pohl M | 2002 | Fertil Steril2002，78，1： | 1 |
| 6 | Pharmacologic treatment of consti-pation:what is new显示文摘 | Pohl D Tutuian R Fried M | | 0，，06： | 1 |
| 7 | Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells 显示文摘 | Moormann C Artuc M Pohl E | 2006 | J Invest Dermatol2006，126，4： | 1 |
| 8 | Immediate effects of speed-dependent treadmill training on gait parameters in early Parkinson's disease显示文摘 | Pohl M Rockstroh G Ruckriem S | 2003 | Arch Phys Med Rehabil2003，84，： | 1 |
| 9 | Optimization and profling of the cache performance of parallel lattice Boltzmann codes 显示文摘 | POHL T KOWARSCHIK M WILKE J IGLBERGER K RUDE U | 2003 | Parallel Process Letters2003，13，4： | 1 |
| 10 | Eliminating amino acid and peptide interference in high-performance anion-exchange pulsed amperometric detection glycoprotein monosaccharide analysis 显示文摘 | Weitzhandler M Pohl C Rohrer J | 1996 | Anal Biochem1996，241，1： | 1 |
| 11 | Speed-depent treadmill training in ambulatory heimiparetic stroke patients:a randomized controlled trial显示文摘 | Pohl M Mehrhol ZJ Ritschel C | 2002 | Stroke2002，33，2： | 1 |
| 12 | Comparison of stimulation with clomiphere citratein combination with recombinant follicle - stimula- ting hormone and recombinant luteinizing hormone to stimulation with a gonodotropin - releasing hormone agonist protocol: a prospective, randomized study显示文摘 | Weiger M Krischker U Pohl M | 2002 | Fertil Steri12002，78，1： | 1 |
| 13 | Cognitive rehabilitation in patients with mild cognitive impairmen显示文摘 | Kurz A Pohl C Ramsenthaler M | 2009 | Int J Geriatr Psychia try2009，24，2： | 1 |
| 14 | Architecture of a protein central to iron homeostasis: crystal structure and spectroscopic analysis of the ferric uptake regulator显示文摘 | Pohl E Haller J C Mijovilovich A Meyer-Klaucke W Garman E Vasil M L | 2003 | Molecular Microbiology2003，47，4： | 1 |
| 15 | Regioselectivity in Cross-Coupling Reactions of 2,6,8-Trichloro-9-(tetrahydropyran-2-y|) purine: Synthesis of 2,6,8-Trisubstituted Purine Bases 显示文摘 | Hocek M Pohl R | 2004 | Synthesis2004，17，： | 1 |
| 16 | Mining SNPs from EST databases显示文摘 | Picoult-Newberg L Ideker T E Pohl M G | 1999 | Genome Res1999，9，： | 1 |
| 17 | Spinal CCL2 pronociceptive action is no longer effective in CCR2 recep- tor antagonist-treated rats显示文摘 | Dansereau MA Gosselin RD Pohl M | 2008 | J Neurochem2008，106，2： | 1 |
| 18 | Stem cells in colon cancer显示文摘 | Pohl A Lurje G Kahn M | 2008 | Clinical Colorectal Cancer2008，7，2： | 1 |
| 19 | Wear in- duced martensite in high chromium cast iron 显示文摘 | SINATORA A POHL M WALDHERR EU | 1995 | Script Mater1995，，32： | 1 |
| 20 | Wear mechanisms of diamond-coated tools显示文摘 | DEUERLER F POHL M TIKANA L | 2001 | Surface and Coatings Technology2001，，： | 1 |
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