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| 1 | Sublingual immunotherapy for pediatric allergic rhinitis: The clinical evidence显示文摘Allergic rhinitis affect 10%-20% of pediatric population and it is caused by the Ig E-sensitization to environmental allergens, most importantly grass pollens and house dust mites. Allergic rhinitis can influence patient's daily activity severely and may precede the development of asthma, especially if it is not diagnosed and treated correctly. In addition to subcutaneous immunotherapy, sublingual immunotherapy(SLIT) represents the only treatment being potentially able to cure allergic respiratory diseases, by modulating the immune system activity. This review clearly summarizes and analyzes the available randomized, double-blinded, placebo-controlled trials, which aimed at evaluating the effectiveness and the safety of grass pollen and house dust mite SLIT for the specific treatment of pediatric allergic rhinitis. Our analysis demonstrates the good evidence supporting the efficacy of SLIT for allergic rhinitis to grass pollens in children, whereas trials regarding pediatric allergic rhinitis to house dust mites present lower quality, although several studies supported its usefulness. | Dimitri Poddighe Amelia Licari Silvia Caimmi Gian Luigi Marseglia | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 7 |
| 2 | Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease:A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening显示文摘BACKGROUND Celiac Disease(CD)is an immune-mediated disorder,in which the HLA immunogenetic background(DQ2 and DQ8 heterodimers)and environmental trigger(gluten)are well established.Indeed,both factors are necessary–but not sufficient–to develop CD.However,it is very likely that CD is underdiagnosed in both developing and developed countries,due to several aspects,including the fact that a lot of patients present mild and/or atypical symptoms,without the presence of any recognized risk factors.Therefore,the possibility and feasibility of widened screening strategies to identify CD patients are debated.AIM To provide further evidence of the main epidemiological importance of HLADQB1*02 allele in the population of CD patients.METHODS We performed a systematic search in PubMed,EMBASE,Cochrane,Web of Science and Scopus databases,in order to produce a systematic review assessing the carrier frequency of HLA-DQB1*02 allele in the celiac population.Following the PRISMA guidelines,we retrieved all the original articles describing CD patients’HLA-DQB1 genotype in such a way that could allow to assess the HLADQB1*02 carrier frequency among CD patients,along with the evidence of the appropriate diagnostic work-up to achieve a correct and final diagnosis of CD.RESULTS The final output of this systematic search in the medical literature consisted of 38 studies providing the appropriate HLA-DQB1 genotype information of the respective CD population.According to this systematic review,including a pool of 4945 HLA-DQ genotyped CD patients,the HLA-DQB1*02 carrier frequency was 94.94%,meaning that only 5.06%of CD patients were completely lacking this allelic variant.Interestingly,if we consider only the studies whereby the prevalence of CD patients affected with type 1 diabetes mellitus was supposed or clearly established to be very low,the frequency of non-HLA-DQB1*02 carriers among CD patients dropped to 3.65%.CONCLUSION Such a high carrier frequency of the HLA-DQB1*02 allelic variant(which is>95%-96%in CD patients without risk factors,like type 1 diabetes mellitus comorbidity)might be exploited to consider a cost-effective and widened screening approach.If a sustainable strategy could be implemented through a low-cost targeted genetic test to detect the individual presence of HLA-DQB1*02 allele,an appropriate algorithm for serological screening in individuals resulting to be genetically predisposed to CD,might be considered. | Dimitri Poddighe Chiara Rebuffi Annalisa De Silvestri Cristina Capittini | 2020 | World Journal of Gastroenterology2020，26，12： | 5 |
| 3 | Celiac Disease in Asia beyond the Middle East and Indian subcontinent:Epidemiological burden and diagnostic barriers显示文摘Celiac Disease(CD)had been considered uncommon in Asia for a long time.However,several studies suggested that,in the Indian subcontinent and Middle East countries,CD is present and as prevalent as in Western countries.Outside these Asian regions,the information about the epidemiology of CD is still lacking or largely incomplete for different and variable reasons.Here,we discuss the epidemiological aspects and the diagnostic barriers in several Asian regions including China,Japan,Southeast Asia and Russia/Central Asia.In some of those regions,especially Russia and Central Asia,the prevalence of CD is very likely to be underestimated.Several factors may,to a different extent,contribute to CD underdiagnosis(and,thus,underestimation of its epidemiological burden),including the poor disease awareness among physicians and/or patients,limited access to diagnostic resources,inappropriate use or interpretation of the serological tests,absence of standardized diagnostic and endoscopic protocols,and insufficient expertise in histopathological interpretation. | Dimitri Poddighe Diyora Abdukhakimova | 2021 | World Journal of Gastroenterology2021，27，19： | 2 |
| 4 | Acute acalculous cholecystitis in children显示文摘Acute acalculous cholecystitis(AAC) is the inflammatory disease of the gallbladder in the absence of gallstones. AAC is estimated to represent at least 50% to 70% of all cases of acute cholecystitis during childhood. Although this pathology was originally described in critically ill or post-surgical patients, most pediatric cases have been observed during several infectious diseases. In addition to cases caused by bacterial and parasitic infections, most pediatric reports after 2000 described children developing AAC during viral illnesses(such as Epstein-Barr virus and hepatitis A virus infections). Moreover, some pediatric cases have been associated with several underlying chronic diseases and, in particular, with immune-mediated disorders. Here, we review the epidemiological aspects of pediatric AAC, and we discuss etiology, pathophysiology and clinical management, according to the cases reported in the medical literature. | Dimitri Poddighe Vitaliy Sazonov | 2018 | World Journal of Gastroenterology2018，24，43： | 2 |
| 5 | Autoimmune pancreatitis and pancreatic cancer:Epidemiological aspects and immunological considerations显示文摘Ordinary chronic pancreatitis is a well-known risk factor for pancreatic cancer,whereas such an association with autoimmune pancreatitis(AIP)is widely debated.Due to the rarity of the latter disorder,there are few specific clinical and epidemiological studies investigating the relation between AIP and pancreatic cancer,which do not seem to support it.However,these studies are affected by several limitations and,therefore,a link between AIP(and,specifically,type 1 AIP)and pancreatic cancer cannot be ruled out definitively on this basis.Moreover,several immunopathological aspects of type 1 AIP and,in general,immunoglobulin G4-related disease can create an immunological context that may impair the tumoral immunosurveillance and promote the pancreatic carcinogenesis and its progression.In detail,Th2 immunological dominance,type 2 macrophage polarization and basophil infiltration observed in type 1 AIP,may play a permissive role in creating a favorable immunological environment for pancreatic carcinogenesis,in addition to the immunosuppressive therapies that can be used in these patients. | Dimitri Poddighe | 2021 | World Journal of Gastroenterology2021，27，25： | 2 |
| 6 | Interphase cytogenetic analysis of cervical intraepithelial neoplasia 显示文摘 | Buhen J Poddighe PJ Robben JC | 1998 | Am J Pathol1998，152，2： | 1 |
| 7 | A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramide显示文摘 | Kerstens HM Poddighe PJ Hanselaar AG | 2001 | J Histochem Cytochem2001，5589，： | 1 |
| 8 | AgarCyto: a novel cell-processing method for multiple molecular diagnostic analyses of the uterine cervix 显示文摘 | Robben JC Poddighe PJ | 2000 | J Histochem Cytochem2000，48，5： | 1 |
| 9 | Protection of isolated rat heart from oxidative stress by exogenous creatine phosphate显示文摘 | Zucchi R Poddighe R Limbruno U | 1989 | J Mol Cell Cardiol1989，21，1： | 1 |
| 10 | Protection of isolated rat heart from oxidative stress by exogenous PCr 显示文摘 | Zuccchi R Poddighe R Limbruno U | 1989 | J Mol Cell Cardiol1989，32，： | 1 |
| 11 | A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramine 显示文摘 | Kerstens HM Poddighe PJ Hanselaar A | 1995 | J Histochem Cytochem1995，43，4： | 1 |
| 12 | A novel in situhybridization signal amplification method based on the deposition ofbiotinylated tyramine显示文摘 | KERSTENS H M PODDIGHE P J HANSELAAR A G | 1995 | J Histochem Cytochem1995，43，4： | 1 |
| 13 | A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramide显示文摘 | Kerstens H M J Poddighe P J Hanselaar A G J M | 1995 | J Histoehem Cytoehem1995，43，： | 1 |
| 14 | Protection of isolated rat heart from oxidative stress by exogenous PCr显示文摘 | Zuccchi R Poddighe R Limbruno U | 1989 | Mol Cell Cardiol1989，32，： | 1 |
| 15 | Novel reliable real-time PCR for differential detection of MSRV env and syncytin-1 in RNA and DNA from patients with multiple sclerosis 显示文摘 | Mameli G Poddighe L Astone V | 2009 | J Virol Methods2009，161，1： | 1 |
| 16 | Mucuna pruriens(Velvet bean)rescues motor,olfactory,mitochondrial and synaptic impairment in PINK1B9 Drosophila melanogaster genetic model of Parkinson's disease显示文摘 | Poddighe S De Rose F Marotta R | 2014 | PLo S One2014，9，11： | 1 |
| 17 | A novel CBFA2single-nucleotide mutation in familial platelet disorder with propensity to develop myeloid malignancies显示文摘 | Buijs A Poddighe P van Wijk R | | 0，，09： | 1 |
| 18 | A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramine显示文摘 | KERSTENS H M PODDIGHE P J HANSELAAR A G | 1995 | J Histochem Cytochem1995，43，4： | 1 |
| 19 | Protection of isolated rat heart from oxidative stress by exogenous CP显示文摘 | ZUCCHI R Poddighe R Limbruno U | 1989 | J Mol Cell Cardiol1989，21，： | 1 |
| 20 | Non-allergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management显示文摘Chronic rhinitis is a very common disease, as the prevalence in the general population resulted to be 40%. Allergic rhinitis has been considered to be the most frequent form of chronic rhinitis, as non-allergic rhinitis has been estimated to account for 25%. However, several evidences suggested that non-allergic rhinitis have been underrated, especially in children. In pediatrics, the diagnostic definition of non-allergic rhinitis has been often limited to the exclusion of an allergic sensitization. Actually, local allergic rhinitis has been often misdiagnosed as well as mixed rhinitis has not been recognized in most cases. Nasal cytology is a diagnostic procedure being suitable for routine clinical practice with children and could be a very useful tool to characterize and diagnose non-allergic rhinitis, providing important clues for epidemiological analysis and clinical management. | Dimitri Poddighe Matteo Gelardi Amelia Licari Michele Miraglia del Giudice Gian Luigi Marseglia | 2016 | World Journal of Methodology2016，6，4： | 1 |
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