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| 1 | Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis. | Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete | 2012 | World Journal of Gastroenterology2012，18，11： | 6 |
| 2 | Ammonium Ion Adsorption and Settleability Improvement Achieved in a Synthetic Zeolite-Amended Activated Sludge显示文摘Municipal wastewater treatment plants typically exhibit two classic problems: high ammonium concentration in water after conventional biological treatment and,in some cases,poor activated sludge sediment ability.Potential solutions to these problems were investigated by adding a synthetic zeolite obtained from coal fly ash to different steps of activated sludge treatment.The experimental results for ammonium removal fit well with the theoretical adsorption isotherms of the Freundlich model with a maximum adsorption capacity of 13.72 mg·g 1.Utilization of this kind of zeolite to improve activated sludge sediment ability is studied for the first time in this work.It is found that the addition of the zeolite(1 g·L 1) to an activated sludge with settling problems significantly enhances its sediment ability and compact ability.This is confirmed by the sludge volume index(SVI),which was reduced from 163 ml·g 1to 70 ml·g 1,the V60value,which was reduced from 894 ml·L 1to 427 ml·L 1,and the zeta potential(ζ),which was reduced from 19.81 mV to 14.29 mV.The results indicate that the addition of this synthetic zeolite to activated sludge,as an additional waste management practice,has a positive impact on both ammonium removal and sludge settleability. | Emilia Otal Luls F. Vilches Yolanda Luna Rodrigo Poblete Juan M. Garcia-Maya Constantino Ferneindez-Pereira | 2013 | Chinese Journal of Chemical Engineering2013，21，9： | 5 |
| 3 | Novel fibrin-fibronectin matrix accelerates mice skin wound healing显示文摘Plasma fibrinogen(F1)and fibronectin(pFN)polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound healing.About 90%of plasma F1 has a homodimeric pair ofγchains(γγF1),and 10%has a heterodimeric pair ofγand more acidicγ′chains(γγ′F1).We have synthesized a novel fibrin matrix exclusively from a 1:1(molar ratio)complex ofγγ′F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII(rFXIIIa).In this matrix,the fibrin nanofibers were decorated with pFN nanoclusters(termedγγ′F1:pFN fibrin).In contrast,fibrin made from 1:1 mixture ofγγF1 and pFN formed a sporadic distribution of“pFN droplets”(termedγγF1+pFN fibrin).Theγγ′F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells(HUVECs)relative to theγγF1+FN fibrin.Three dimensional(3D)culturing showed that theγγ′F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human fibroblasts.HUVECs in the 3Dγγ′F1:pFN fibrin exhibited a starkly enhanced vascular morphogenesis while an apoptotic growth profile was observed in theγγF1+pFN fibrin.Relative toγγF1+pFN fibrin,mouse dermal wounds that were sealed byγγ′F1:pFN fibrin exhibited accelerated and enhanced healing.This study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing. | Carlos Poblete Jara Ou Wang Thais Paulino do Prado Ayman Ismail Frank Marco Fabian Han Li Licio A.Velloso Mark A.Carlson William Burgess Yuguo Lei William H.Velander Eliana P.Araújo | 2020 | Bioactive Materials2020，5，4： | 5 |
| 4 | Single port access(SPA) chelecystectomy:a completely trznsumbilical approach显示文摘 | Podolsky ER Rottman SJ Poblete H | 2009 | J Laparoendosc Adv Surg Tech A2009，19，2： | 1 |
| 5 | Metastatic carcinoid tumor in the liver 显示文摘 | Dogra VS Poblete J | 1993 | Clin Uhrasound1993，21，9： | 1 |
| 6 | Single port access(SPA) cholecystectnmy: a completely transumbilical approach 显示文摘 | Podolsky ER Rottman SJ Poblete H | 2009 | J La- paroendose Adv Surg Tech A2009，19，2： | 1 |
| 7 | Effects of fermentation temperature on the strain population of Saccharomyces cerevisiae显示文摘 | TORIJA M J ROZES N POBLET M | 2003 | International journal of food microbiology2003，80，1： | 1 |
| 8 | Clonidine-induced nitric oxide-dependent vasorelaxation mediated by endothelial alpha ( 2 ) -adrenoceptor activation 显示文摘 | FIGUEROA X F POBLETE M I BORIC M P | 2001 | Br J Pharmacol2001，134，5： | 1 |
| 9 | Acute Hemorrhagic Conjunctivitis- St Croix, US Virgin Islands, September-October 1998 显示文摘 | J Poblete A Bermudez-Walcott V Ebbesen-Fludd | 1998 | MMWR1998，47，： | 1 |
| 10 | Metastatic carcinoid tumor in the liver显示文摘 | Dogra V S Poblete J | 1993 | Clinultrasound1993，21，9： | 1 |
| 11 | Quantification of the expression of reference and alcohol dehydrogenase genes of some acetic acid bacteria in different growth conditions 显示文摘 | Quintero Y Poblet M Guillamon J M | 2009 | Journal of applied microbiology2009，106，2： | 1 |
| 12 | Relative basicities of the oxygen sites in ^6-显示文摘 | Kempf J Y Rohmer M M Poblet J M | 1992 | J Am Chem Soc1992，114，： | 1 |
| 13 | Asymptomatic pulmonary artery sling:Noninvasive diagnosis显示文摘 | ORTIGADO MATAMALA A GARCIA GARCIA A GALICIA POBLET G | 2010 | An Pediatr2010，72，3： | 1 |
| 14 | Primary adenoid cystic carcinoma of the mandible: case re- port and review of the literature显示文摘 | Garcia de Marcos JA Calder6n-Polanco J Poblet E | 2008 | J Oral Maxillofac Surg2008，66，12： | 1 |
| 15 | P2Y1 receptor activation elicits its partition out of membrane rafts and its rapid internalization from human blood vessels: implications for receptor signalling 显示文摘 | Norambuena A Poblete MI Donoso MV | 2008 | Mol Pharmacol2008，74，6： | 1 |
| 16 | The role of studs in the sound transmission of double walls 显示文摘 | Poblet J Puig Rodriguez A Ferran Guigou C Carter | 2009 | Acta Acusfica United with Acustica2009，95，： | 1 |
| 17 | Geometric and numerical model of pro- gressive limb rotation in detachment folds显示文摘 | Hardy S Poblet J | 1994 | Geology1994，22，4： | 1 |
| 18 | Small bowel perforation caused by an impacted endocapsule显示文摘 | S. Um H. Poblete J. Zavotsky | 2008 | Endoscopy . 2008 (S 02)2008，，02： | 1 |
| 19 | Comparative study of manual and ultrasonic instrumentation of cementum surfaces:influence of lateral pressure显示文摘 | GAGNOT G MORA F POBLETE M G | 2004 | Int J Periodontics Restorative Dent2004，24，2： | 1 |
| 20 | Geometries of syntecton- ic sediments associated with single-layer detachment folds 显示文摘 | Poblet J Mcclay K Storti F | 1997 | Journal of Structural Geology1997，19，34： | 1 |
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