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| 1 | Feed- and feed additives-related aspects of gut health and development in weanling pigs显示文摘The development of new/different management and feeding strategies to stimulate gut development and health in newly-weaned pigs, in order to improve growth performance while minimizing the use of antimicrobial compounds such as antibiotic growth promotants (AGP) and heavy mineral compounds, is essential for the long-term sustainability of the pig industry. Factors including the sub-optimal intake of nutrients and energy, inappropriate microbiota biomass and (or) balance, immature and compromised immune function, and psychosomatic factors caused by weaning can compromise both the efficiency of digestion and absorption and intestinal barrier function through mucosal damage and alteration of tight junction integrity. As a consequence, pigs at weaning are highly susceptible to pathogenic enteric conditions such as post-weaning diarrhea that may be caused by serotypes of enterotoxigenic Escherichia coli. Many dietary components, e.g., protein, fiber, feed additives and minerals, are known to influence microbial growth in the gastrointestinal tract that in turn can impact upon pig growth and health, although the relationships between these are sometimes not necessarily apparent or obvious. In a world climate of increased scrutiny over the use of antibiotics per se in pig production, certain feed additives are seen as alternatives/replacements to antibiotics, and have evolved in some cases to have important roles in everyday commercial pig nutrition. Nevertheless and in general, there remains inconsistency and variability in the efficacy of some feed additives and in cases of severe disease outbreaks, for example, therapeutic antibiotics and/or heavy minerals such as zinc oxide (ZnO) are generally relied upon. If feed ingredients and (or) feed additives are to be used with greater regularity and reliability, then it is necessary to better understand the mechanisms whereby antibiotics and minerals such as ZnO influence animal physiology, in conjunction with the use of appropriate challenge models and in vitro and in vivo techniques. | John R Pluske | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 11 |
| 2 | Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic E.coli显示文摘Background: This experiment was conducted to test the hypothesis that vitamin E(Vit E) and acetylsalicylic acid(ASA), a cyclooxygenase-2(COX-2) inhibitor, will additively reduce the production of the immunosuppressive molecule prostaglandin E_2(PGE_2) and hence reduce inflammatory responses in weaner pigs experimentally infected with an enterotoxigenic strain of E. coli.Methods: The experiment was conducted in a research facility with 192 individually-housed male weaner pigs(Landrace × Large White) weighing 6.6 ± 0.04 kg(mean ± SEM). The pigs were experimentally infected with an enterotoxigenic strain of E. coli and were allocated to a 2 × 3 factorial design with the respective factors being without and with 125 ppm ASA and three levels of Vit E supplementation(50, 100 or 200 IU/kg diet, dl-α-tocopheryl acetate).Results: Acetylsalicylic acid supplementation improved average daily gain(P < 0.05) and tended to improve feed:gain ratio(P < 0.10) during the first 14 d after weaning. Acetylsalicylic acid supplementation also improved(P < 0.001) amino acid utilization efficiency(as assessed by plasma urea level) and tended to decrease(P < 0.10) PGE_2 production in the liver without affecting smal intestinal histology and tight junction protein mR NA expression in the jejunal epithelium. Vitamin E supplementation greater than 100 IU/kg diet sustained both the plasma Vit E concentration(P < 0.001) and plasma haptoglobin content(P < 0.001) after weaning. However, there was no additive effects of the combined supplementation of ASA and Vit E on performance, intestinal barrier function and inflammatory responses of weaned pigs.Conclusions: Although ASA and vitamin E improved amino acid utilization efficiency and reduced acute inflammatory responses, ASA and vitamin E did not additively reduce production of PGE_2 and inflammatory responses in weaner pigs experimental y infected with an enterotoxigenic strain of E. coli. | Jae Cheol Kim Bruce P. Mullan John L. Black Robert J. E. Hewitt Robert J. van Barneveld John R. Pluske | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 2 |
| 3 | A comparison of waxy versus non-waxy wheats in diets for weaner pigs: effects of particle size, enzyme supplementation, and collection day on total tract apparent digestibility and pig performance显示文摘 | J.C. Kim B.P. Mullan J.R. Pluske | 2005 | Animal Feed Science and Technology2005，，1： | 2 |
| 4 | The effects of increasing lev- els of soluble non-starch polysaccharides and inclusion of feed enzymes in dog diets on faecal quality and digestibility显示文摘 | TWOMEY L PLUSKE J ROWE J | 2003 | An Feed Sei Teehnol2003，108，14： | 1 |
| 5 | The digestible energy value of wheat for pigs, with special reference to the post-weaned animal [Review]显示文摘 | J.C. Kim P.H. Simmins B.P. Mullan J.R. Pluske | 2005 | Animal Feed Science and Technology2005，，3： | 1 |
| 6 | The use of nucleotides, vitamins and functional aminoacids to enhance the structure of the small intestineand circulating measures of immune function in thepost-weaned piglets 显示文摘 | MOORE K L MULLAN B P PLUSKE J R | 2011 | Animal Feed Science andTechnology2011，165，： | 1 |
| 7 | Effects of different sources and levels of dietary fibre in diets on performance, digesta characteristics and antibiotic treatment of pigs after weaning 显示文摘 | Pluske JR Black B Pethick DW | 2003 | Anim Feed Sci Technol2003，107，： | 1 |
| 8 | Maimtenance of Villous Height and Crypt Depth in Piglets by Providing Continuous Nutrition After Weaning显示文摘 | Pluske J R Williams I H Aherne F X | 1996 | J Anim Sic1996，62，1： | 1 |
| 9 | Strategic use of feed ingredients and feed additives to stimulate gut health and development in young pigs显示文摘 | de Lange C F M Pluske J Gong J | 2010 | Livestock Science2010，134，13： | 1 |
| 10 | Nutri- tional influences on some major enteric bacterial diseases of pigs显示文摘 | PLUSKE J R PETHICK D W HOPWOOD D E | 2002 | Nutr Res Rev2002，15，： | 1 |
| 11 | Factors influencing the structure and function of smallintestine in the weaned pig: areviews显示文摘 | Pluske J R Hampson D J Williams I D | 1997 | Livestock Production Science1997，51，： | 1 |
| 12 | Maintenance of villus height and crypt depth in piglets by providing continuous nutrition of weaning显示文摘 | Pluske J R William I H Aherne F X | 1996 | Animal Science1996，62，1： | 1 |
| 13 | Gastrointestinal health and function in weaned pigs:a review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds 显示文摘 | HEO J M OPAPEJU F O PLUSKE J R | 2013 | Journal of Animal Physiology and Animal Nutrition2013，97，2： | 1 |
| 14 | Factors influencing the structure and function of the small intestine in the weaned pig显示文摘 | Hampson D J Williams I H | 1997 | Livest Prod Sci1997，51，： | 1 |
| 15 | Maintaince of villous height and crept depth in piglets by providing continuous nutrition after weaning显示文摘 | Pluske J R Williams I H | 1996 | Anim Sci1996，62，： | 1 |
| 16 | Factors influencing the structure and function of the small intestinal in the weaned pig显示文摘 | Pluske J R Hampsom D Williams J | 1997 | Livest Prod Sci1997，51，： | 1 |
| 17 | Factors influencing the structure and function of the small intestine in the weaned pig: a review显示文摘 | John R. Pluske David J. Hampson Ian H. Williams | 1997 | Livestock Production Science1997，，1： | 1 |
| 18 | Maintenance of villus height and crypt depth,and enhancement of disaccharide digestion and monosaccharide absorption,in piglets fed on cows' whole milk after weaning显示文摘 | Pluske J R Thompson M J Atwood C S | 1996 | Br J Nutr1996，76，3： | 1 |
| 19 | Strategic use of feed ingredients and feed additives to stimulate gut health and development in young pigs 显示文摘 | C F M de Lange J Pluske J Gong | 2010 | Livestock Science2010，134，1： | 1 |
| 20 | Factors inlfuencing the structure and function of the small intestine in the weaned pig:a review显示文摘 | Pluske J R Hampson D Williams L H | | 0，，1： | 1 |
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