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| 1 | Mobilization of CD34^+CD38^- hematopoietic stem cells after priming in acute myeloid leukemia显示文摘AIM: To evaluate quantitatively and qualitatively the different CD34+cell subsets after priming by chemotherapy granulocyte colony-stimulating factor(± G-CSF)in patients with acute myeloid leukemia.METHODS: Peripheral blood and bone marrow sampleswere harvested in 8 acute myeloid leukemia patients during and after induction chemotherapy. The CD34/CD38 cell profile was analyzed by multi-parameter flow cytometry. Adhesion profile was made using CXC chemokine receptor 4(CXCR4)(CD184), VLA-4(CD49d/CD29) and CD47.RESULTS: Chemotherapy ± G-CSF mobilized immature cells(CD34+CD38 population), while the more mature cells(CD34+CD38lowand CD34+CD38+populations) decreased progressively after treatment. Circulating CD34+cells tended to be more sensitive to chemotherapy after priming with G-CSF. CD34+cell mobilization was correlated with a gradual increase in CXCR4 and CD47expression, suggesting a role in cell protection and the capacity of homing back to the marrow.CONCLUSION: Chemotherapy ± G-CSF mobilizes into the circulation CD34+bone marrow cells, of which, the immature CD34+CD38-cell population. Further manipulations of these interactions may be a means with which to control the trafficking of leukemia stem cells to improve patients' outcomes. | Adriana Plesa Eve Mattei Charles Dumontet Youcef Chelghoum Hélène Labussière Giovanna Cannas Mauricette Michallet Xavier Thomas Mohamed Elhamri Stéphane Morisset Inès Tagoug | 2013 | World Journal of Stem Cells2013，5，4： | 1 |
| 2 | TCR affinity and specificity requirements for human regulatory T-cell function显示文摘 | Plesa G Zheng L Medvec A | 2012 | Blood2012，119，15： | 1 |
| 3 | Lexical and affec tive prosody in children with high functioning autism显示文摘 | Grossman RB Bemis RH Plesa SD | 2010 | J Speech Lang Hear Res2010，53，3： | 1 |
| 4 | The inducible costimulator ( ICOS ) is critical for the development of human T (H)17 ceils 显示文摘 | Paulos CM Carpenito C Plesa G | 2010 | Sci Transl Med2010，2，55： | 1 |
| 5 | Bloody nipple discharge in infan-cy:a case report and recommendations for management显示文摘 | Plesa Premilovac Z Tokie V | 2013 | JPediatr and Adolesc Gynecol2013，26，： | 1 |
| 6 | Engineered T cells for cancer therapy显示文摘 | June CH Maus MV Plesa G | 2014 | Cancer Immunol Immunother2014，63，9： | 1 |
| 7 | Efficacy of Helicobacter pylori eradication therapy in cirrhotic patients with peptic ulcer disease显示文摘 | Mitrica D Plesa A Constantinescu R | 2011 | Rev Med Chir Soc Med Nat Iasi2011，115，2： | 1 |
| 8 | Auto radiators-study regarding air flow along the channels 显示文摘 | DAMIAN R M PLESA A GIURGIU O | 2016 | Energy Procedia2016，85，： | 1 |
| 9 | Energy efficient coils for magnetic stimulation of peripheral nerves显示文摘 | Darabant L Plesa M Mien DD | 2009 | IEEE Transactions on Magnetics2009，45，3： | 1 |
| 10 | High frequency of CD34+CD38-/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia显示文摘AIM To evaluate the importance of the CD34+CD38-cell population when compared to the CD34+CD38+/low and CD34+CD38+/high leukemic cell sub-populations and to determine its correlations with leukemia characteristics and known prognostic factors, as well as with response to therapy and survival.METHODS Two hundred bone marrow samples were obtained at diagnosis from 200 consecutive patients with newly diagnosed acute myeloid leukemia(AML) were studied between September 2008 and December 2010 at our Institution(Hematology Department, Lyon, France). The CD34/CD38 cell profile was analyzed by multiparameter flowcytometry approach using 8 C panels and FACS CANTO and Diva software(BD Bioscience).RESULTS We analyzed CD34 and CD38 expression in bone marrow samples of 200 AML patients at diagnosis, and investigated the prognostic value of the most immature CD34+CD38-population. Using a cut-off value of 1% of CD34+CD38-from total 'bulk leukemic cells' we found that a high(> 1%) level of CD34+CD38-blasts at diagnosis was correlated with advanced age, adverse cytogenetics as well as with a lower rate of complete response after induction and shorter disease-free survival. In a multivariate analysis considering age, leukocytosis, the % of CD34+ blasts cells and the standardized cytogenetic and molecular risk subgroups, a percentage of CD34+CD38-leukemic cells > 1% was an independent predictor of DFS [HR = 2.8(1.02-7.73), P = 0.04] and OS [HR = 2.65(1.09-6.43), P = 0.03].CONCLUSION Taken together, these results show that a CD34/CD38 'backbone' for leukemic cell analysis by multicolour flowcytometry at diagnosis provides useful prognostic information. | Adriana Plesa Charles Dumontet Eve Mattei Ines Tagoug Sandrine Hayette Pierre Sujobert Isabelle Tigaud Marie Pierre Pages Youcef Chelghoum Fiorenza Baracco Helene Labussierre Sophie Ducastelle Etienne Paubelle Franck Emmanuel Nicolini Mohamed Elhamri Lydia Campos Claudiu Plesa Stéphane Morisset Gilles Salles Yves Bertrand Mauricette Michallet Xavier Thomas | 2017 | World Journal of Stem Cells2017，9，12： | 1 |
| 11 | Prognostic value of immuno-phenotyping in elderly patients with acute myeloid leukemia : A sin-gle -institution experience显示文摘 | Plesa C Chelghoum Y Plesa A | 2008 | Cancer2008，112，3： | 1 |
| 12 | Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia cancer显示文摘 | PLESA C CHELGHOUM Y PLESA A | 2008 | Cancer2008，112，： | 1 |
| 13 | Gene editing of CCR5 in autologous CD4 T cells ofpersons infected with HIV 显示文摘 | Tebas P Stein D Tang WW Frank I Wang SQ Lee G Spratt SK Surosky RT Giedlin MA Nichol G HolmesMC Gregory PD Ando DG Kalos M Collman RG Binder-Scholl G Plesa G Hwang WT Levine BL JuneCH | 2014 | N Engl J Med2014，370，10： | 1 |
| 14 | Prognostic value of im- munophenotyping in elderly patients with acute myeloid leu- kemia cancer显示文摘 | Plesa C Chelghoum Y Pleas A | 2008 | Cancer2008，112，3： | 1 |
| 15 | Efficacy of Helicobacter pylori eradication therapy in cirrhotic patients with peptic ulcer disease显示文摘 | Mitrica D Plesa A Constantinescu R | | 0，，： | 1 |
| 16 | Engineered T cells for cancertherapy 显示文摘 | JUNE CH MAUS MV PLESA G | 2014 | Cancer Immunol Immunother2014，63，9： | 1 |
| 17 | Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia:a single-institution experience显示文摘 | Plesa C Chelghuom Y Plesa A | 2008 | Cancer2008，112，3： | 1 |
| 18 | Molecular variants of human papilloma virus 16 E2,E4,ES,E6 and E7 genes associated with cervical neopIasia in Romanian patients 显示文摘 | Plesa A Anton G Iancu IV | 2014 | Arch Virol2014，159，12： | 1 |
| 19 | Efficacy of Helico- bacter pylori eradication therapy in cirrhotic patients with pe- ptic ulcer disease 显示文摘 | Mitrici D Plesa A Constantinescu R | 2011 | Rev Med Chir Soc Med Nat Iasi2011，5，2： | 1 |
| 20 | Conservation of the opcL gene encoding the peptidoglycan-associated outermembrane lipoprotein among representatives of the Burkholderia cepacia complex显示文摘 | Plesa M Kholti A Vermis K | | 0，，05： | 1 |
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