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| 1 | Defective autophagy and Alzheimer’s disease: is calcium the key?显示文摘Presenilins and autophagy: Presenilin 1 (PS1) and presenilin 2 (PS2) are homologous, multi-pass transmembrane proteins endowed with pleiotropic functions, ranging from the regulation of membrane trafficking to cell differentiation. Their catalytic activity within the γ-secretase complex, an aspartyl-protease responsible for the intramembrane cleavage of several different type I transmembrane proteins, has been intensively studied in the context of Alzheimer’s disease (AD). Indeed, tens of autosomal dominant mutations in the PSEN1 and PSEN2 genes (encoding PS1 and PS2, respectively) have been associated with the rare familial forms of AD (FAD). | Riccardo Filadi Paola Pizzo | 2019 | Neural Regeneration Research2019，14，12： | 3 |
| 2 | Diagnostic delay in oral squamous cell carcinoma: the role of cognitive and psychological variables显示文摘This retrospective study investigated, in two cohorts of subjects living in Southern Italy and awaiting treatment for oral squamous cell carcinoma(OSCC), the variables related to diagnostic delay ascribable to the patient, with particular reference to the cognitive and psychological ones. A total of 156 patients with OSCC(mean age: 62 years, M/F: 2.39 : 1) were recruited at the Universities of Palermo and Naples. Risk factors related to patient delay included: sociodemographic, health-related, cognitive and psychological variables. The analysis was conducted by considering two different delay ranges: dichotomous(f1 month vs..1 month) and polytomous(,1 month, 1–3 months,.3 months) delay. Data were investigated by univariate and multivariate analyses and a P value f0.05 was considered statistically significant. For both delay measurements, the most relevant variables were: ‘Personal experience of cancer'(dichotomous delay: P50.05, odds ratio(OR)50.33, 95% confidence interval(CI)50.11–0.99; polytomous delay: P50.006, Chi-square510.224) and ‘Unawareness'(dichotomous delay: P,0.01, OR54.96, 95% CI52.16–11.37; polytomous delay: P50.087, Chi-square54.77). Also ‘Denial'(P,0.01, OR56.84, 95% CI52.31–20.24) and ‘Knowledge of cancer'(P50.079, Chi-square58.359) were found to be statistically significant both for dichotomous and for polytomous categorization of delay, respectively. The findings of this study indicated that, in the investigated cohorts, the knowledge about cancer issues is strongly linked to the patient delay. Educational interventions on the Mediterranean population are necessary in order to increase the patient awareness and to emphasize his/her key role in early diagnosis of OSCC. | Vera Panzarella Giuseppe Pizzo Francesco Calvino Domenico Compilato Giuseppe Colella Giuseppina Campisi | 2014 | International Journal of Oral Science2014，6，1： | 2 |
| 3 | Nosocomial fungal infections 显示文摘 | Walsh T J Pizzo P A | | Annu Rev Microbiol0，42，： | 2 |
| 4 | Arthroscopic treatment of anterolateral impingement of the ankle显示文摘 | Ferkel RD Karzel RP Del Pizzo W | | 0，，： | 1 |
| 5 | Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with D-Chiro-Inositol 显示文摘 | Lagana AS Barbaro L Pizzo A | 2015 | Arch Gyne- col Obstet2015，291，5： | 1 |
| 6 | Releasable vascular plasminogen activator and thrombotic strokes显示文摘 | Pizzo SU | 1985 | Am J Med1985，79，： | 1 |
| 7 | Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha (2)-maeroglobulin signalling receptor显示文摘 | MISRA UK PIZZO SV | 2001 | Cell Signal2001，13，11： | 1 |
| 8 | Granulocyte colony stimulating factors enhances the phagocytic and bactericidal activity of normal and defective human neutrophils显示文摘 | Roilides E Walsh TJ Pizzo PA | 1991 | J Infect Dis1991，163，3： | 1 |
| 9 | Behavior of cytokine levels in serum and peritoneal fluid of women with endometriosis 显示文摘 | Pizzo A Satmeri FM Ardita FV | 2002 | Gynecol Obstet Invest2002，54，2： | 1 |
| 10 | Solvent-free A1 (OTf) 3-catalyzed aminolysis of 1,2-epoxides by 2-picolylamine : A key step in the synthesis of ionic liquids显示文摘 | FRINGUELLI F PIZZO F TORTOIOLI S | 2004 | Org Chem2004，69，22： | 1 |
| 11 | Cytokines and biological response modifiers in the treatment of infection 显示文摘 | Mueller BU Pizzo PA | 1998 | Cancer Treat Res1998，96，： | 1 |
| 12 | Focus on diagnosis: congenital infections (TORCH) 显示文摘 | Del Pizzo J | 2011 | Pediatr Rev2011，32，5： | 1 |
| 13 | The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary edema 显示文摘 | Schoene RB Swenson ER Pizzo CJ | 1988 | J Appl Physiol1988，64，： | 1 |
| 14 | Behaviour of cytokine levels in serum and peritoneal fluid of women with endometriosiss 显示文摘 | Pizzo A Salmeri FM Ardita FV | 2002 | Gynecol Obstet Invest2002，54，2： | 1 |
| 15 | Accuracy diagnosis from magnetic resonance imaging of the knee 显示文摘 | Fischer SP Fox JM Del Pizzo W | 1991 | J Bone Joint Surg(AM)1991，73，： | 1 |
| 16 | High -performance liquid chromatograph method for analysis of 2 ',3'-dideoxyinosine in human body fluids显示文摘 | Carpen ME Poplack DG Pizzo PA | 1990 | J Chromatograph1990，526，： | 1 |
| 17 | Cyclosporin- and nifedipine- induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens 显示文摘 | Margiotta V Pizzo I Pizzo G | 1996 | J Oral Pathol Med1996，25，3： | 1 |
| 18 | Ribonuclease/angiogenin inhibitor 1 regulates stress-induced subcellular localization of angiogenin to control growth and survival 显示文摘 | Pizzo E Sarcinelli C Sheng J | 2013 | J Cell Sci2013，126，18： | 1 |
| 19 | Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells显示文摘 | Rizzuto R Brini M Pizzo P | 1995 | Curr Biol1995，5，： | 1 |
| 20 | Urological complications of bladder-drained pancreatic allografts 显示文摘 | Jacobs SC Bartlett ST | 1998 | Br J Urol1998，81，4： | 1 |
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