| 1 | Varicocele management in the era of in vitro fertilization/intracytoplasmic sperm injection显示文摘精索静脉曲张是男不孕的最普通的通过手术可对待的原因,并且经常在精液参数,精子 DNA 损坏,和精液的周围的变化导致改变。精索静脉曲张修理能与临床的精索静脉曲张在人的多数在这些参数导致改进;与无临床症状的精索静脉曲张在人支持修理的数据是不太权威的。在用帮助繁殖技术(艺术)寻求富饶的夫妇,精索静脉曲张修理可以在能用技术例如增加成功的授精的可能性的精液参数和精子健康提供改进在 vitro 授精( IVF )或 intracytoplasmic 精子注射( ICSI ),或可以减少艺术的水平需要完成成功的怀孕。男不孕是有向健康能便于最佳的屏蔽和这些人的治疗的未来的一只眼睛的不肥沃的男性的一般男健康,和评估的指示物。而且,精索静脉曲张可以代表进步损害,提供为它的修理的争论,尽管这当前是不清楚的。 | Piyush Pathak Aravind Chandrashekar Tariq S Hakky Alexander W Pastuszak | 2016 | Asian Journal of Andrology2016，18，3： | 5 |
| 2 | Effect of thrombocytopenia and platelet transfusion on outcomes of acute variceal bleeding in patients with chronic liver disease显示文摘BACKGROUND Platelet transfusion in acute variceal bleeding(AVB)is recommended by few guidelines and is common in routine clinical practice,even though the effect of thrombocytopenia and platelet transfusion on the outcomes of AVB is unclear.AIM To determine how platelet counts,platelets transfusions,and fresh frozen plasma transfusions affect the outcomes of AVB in cirrhosis patients in terms of bleeding control,rebleeding,and mortality.METHODS Prospectively maintained database was used to analyze the outcomes of cirrhosis patients who presented with AVB.The outcomes were assessed as the risk of rebleeding at days 5 and 42,and risk of death at day 42,considering the platelet counts and platelet transfusion.Propensity score matching(PSM)was used to compare the outcomes in those who received platelet transfusion.Statistical comparisons were done using Kaplan-Meier curves with log-rank tests and Coxproportional hazard model for rebleeding and for 42-d mortality.RESULTS The study included 913 patients,with 83.5%men,median age 45 years,and Model for End-stage Liver Disease score 14.7.Platelet count<20×10^(9)/L,20-50×10^(9)/L,and>50×10^(9)/L were found in 23(2.5%),168(18.4%),and 722(79.1%)patients,respectively.Rebleeding rates were similar between the three platelet groups on days 5 and 42(13%,6.5%,and 4.7%,respectively,on days 5,P=0.150;and 21.7%,17.3%,and 14.4%,respectively,on days 42,P=0.433).At day 42,the mortality rates for the three platelet groups were also similar(13.0%,23.2%,and 17.2%,respectively,P=0.153).On PSM analysis patients receiving platelets transfusions(n=89)had significantly higher rebleeding rates on day 5(14.6%vs 4.5%;P=0.039)and day 42(32.6%vs 15.7%;P=0.014),compared to those who didn't.The mortality rates were also higher among patients receiving platelets(25.8%vs 23.6%;P=0.862),although the difference was not significant.On multivariate analysis,platelet transfusion and not platelet count,was independently associated with 42-d rebleeding.Hepatic encephalopathy was independently associated with 42-d mortality.CONCLUSION Thrombocytopenia had no effect on rebleeding rates or mortality in cirrhosis patients with AVB;however,platelet transfusion increased rebleeding on days 5 and 42,with a higher but nonsignificant effect on mortality. | Sagnik Biswas Manas Vaishnav Piyush Pathak Deepak Gunjan Soumya Jagannath Mahapatra Saurabh Kedia Gyanranjan Rout Bhaskar Thakur Baibaswata Nayak Ramesh Kumar Shalimar | 2022 | World Journal of Hepatology2022，14，7： | 0 |
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