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| 1 | Effects of L-carnitine in patients with hepatic encephalopathy显示文摘AIM: To evaluate the influence of L-carnitine on mental conditions and ammonia effects on patients with hepatic encephalopathy (HE).METHODS: One hundred and fifty patients (10 patients with alcoholism, 41 patients with hepatitis virus B infection, 78 patients with hepatitis C virus infection,21 patients with cryptogenetic cirrhosis) meeting the inclusion criteria were randomized into group A receiving a 90-d treatment with L-carnitine (2 g twice a day) or into group B receiving placebo in double blind.RESULTS: At the end of the study period, a significant decrease in NH4 fasting serum levels was found in patients with hepatic encephalopathy (P<0.05) afler the treatment with levocarnitine (LC). Significant differences were also found between symbol digit modalities test and block design in patients with hepatic encephalopathy (P<0.05).CONCLUSION: Results of our study suggest an important protective effect of L-carnitine against ammonia-precipitated encephalopathy in cirrhotic patients. | Mariano Malaguarnera Giovanni Pistone Rampello Elvira Carmelo Leotta Linda Scarpello Rampello Liborio | 2005 | World Journal of Gastroenterology2005，11，45： | 14 |
| 2 | The role of cyclooxygenase-2/prostanoid pathway in visceral pain induced liver stress response in rats显示文摘背景 Cyclooxygenase (艇长)是在从 arachidonic acid.COX-2 的 prostanoids 的生产的限制率的酶是在 COX 家庭的可诱导的酶,和 COX-2/prostanoid pathway.Research 显示出的 prostanoids 形式 COX-2/prostanoid 小径在肝的疾病和肝压力反应被激活例如 fibrogenesis ,门高血压, carcinogenesis ,和 ischemic/reperfusion 损害。但是内脏的疼痛上没有报告导致的肝应力。这研究是在老鼠在肝压力反应调查 COX-2/prostanoid 小径的角色尖锐的大肠炎内脏的疼痛肝压力 model.Methods 53 只男 SD 老鼠随机被划分成天真,模型, NS398 处理,和吗啡处理组。老鼠尖锐大肠炎内脏的疼痛肝压力模型被 6% 醋酸的 0.5 ml 的结肠的管理用一根尿道的导管在麻醉下面建立。NS398 和吗啡被管理在在 NS398 和吗啡处理组的模型建立以前的 30 分钟分别地。自发的活动和疼痛行为被数,结肠的发炎的程度组织学地被估计。活动, COX-2 mRNA ,前列腺素 E2 ( PGE2 ), thromboxane B2 ( TXB2 )和 6-Ketone-prostaglandin F1 ( 6-K-PGF1 )满足的 Glutathione-S-Transferase ( GST )的肝织物层次是 assessed.Results 在醋酸的结肠的管理以后的三十分钟,在自发的活动的重要减少和疼痛行为的增加在模型组被观察( P0.01 和 P0.05 分别地),由结肠的发炎伴随了。显著地掉的肝 GST 活动层次(P0.05 ) 。显著地增加的肝 COX-2 mRNA 表示,由肝集中的增加伴随了 PGE2 和 TXB2,而是在 6-K-PGF1 集中的没有明显的变化。NS398 和吗啡两个都改善了压力以后的肝 GST 活动(P0.05 并且 P0.01respectively ) ,减少的导致压力的 COX-2 表示,减少的 PGE2 和 TXB2 生产,而是增加的肝 6-K-PGF1 层次。在结肠的组织发炎的吗啡变细在 24 个小时(P0.05 ) 是明显的 .Conclusions 内脏的疼痛肝应力能导致的尖锐大肠炎肝损害。肝损害可能通过 COX-2/prostanoid 小径的激活发生了并且增加了 PGE2 和 TXB2 的生产。有效痛觉缺失可能在内脏的疼痛应力期间提供保护的效果。 | PISTON Donald WANG Shan FENG Yi YE Ying-jiang ZHOU Jing JIANG Ke-wei XU Feng ZHAO Yong CUI Zhi-rong | 2007 | Chinese Medical Journal2007，，20： | 6 |
| 3 | Gender specific medicine in liver diseases:a point of view显示文摘Gender medicine focuses on the patho-physiological,clinical,prevention and treatment differences in diseases that are equally represented in men and women.The purpose of gender medicine is to ensure that each individual man and woman receives the best treatment possible based on scientific evidence.The concept of'gender'includes not only the sexual characteristics of individuals but also physiological and psychological attributes of men and women,including risk factors,protective/aggravating effects of sexual hormones and variances linked to genetics and corporal structures that explain biological and physiological differences between men and women.It is very important to consider all the biological,physiological,functional,psychological,social and cultural characteristics to provide patients with individualized disease management.Herein,we critically analyze the literature regarding gender differences for diseases and acquired conditions of the most representative hepatic pathologies:primary biliary cirrhosis,autoimmune hepatitis,primary sclerosing cholangitis,non alcoholic fatty liver disease and alcoholic liver disease,and viral chronic hepatitis B and C.The last section addresses hemochromatosis,which is a prevalent iron overload disorder in the Caucasian population.This review aims to describe data from the literature concerning viral chronic hepatitis during pregnancy,management during pregnancy and delivery,and new effective drugs for the prevention of maternal infection transmission without significant adverse effects or complications. | Marilena Durazzo Paola Belci Alessandro Collo Vanessa Prandi Erika Pistone Maria Martorana Roberto Gambino Simona Bo | 2014 | World Journal of Gastroenterology2014，20，9： | 3 |
| 4 | The strain amplitude-controlled cyclic fatigue behavior of Al_2O_3 fiber reinforced Al-Si alloy composite at elevated temperatures | Guohua Zhang a,c,Bingchao Li b,Jianxin Zhang b,Wei Cai a a School of Materials Science and Engineering,Harbin Institute of Technology,Harbin 150001,China b School of Materials Science and Engineering,Shandong University,Jinan 250061,China c Shandong Binzhou Bohai Piston Co.,Ltd,Binzhou 256602,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 2 |
| 5 | Unique cyclic deformation behavior of a heavily alloyed Al-Si piston alloy at different temperatures | Guohua Zhang a,c,Bingchao Li b,Jianxin Zhang b,Zengjian Feng c,Zuoshan Wei c,Wei Cai a a School of Materials Science and Engineering,Harbin Institute of Technology,92 West Dazhi Street,P.O.Box 405,Harbin 150001,China b School of Materials Science and Engineering,Shandong University,17923 Jingshi Road,Jinan 250061,China c Shandong Binzhou Bohai Piston Co.,Ltd,569 Bohai Ershiyi Road,Binzhou 256602,China | 2012 | Progress in Natural Science:Materials International2012，22，5： | 2 |
| 6 | Regulation of co repressor function by nuclear NADH显示文摘 | Zhang Q Piston D W Goodman R H | 2002 | Science2002，295，： | 1 |
| 7 | The fan of an experimental design显示文摘 | Caboara M Pistone G Riccomagno E Wynn H P | 1998 | Preprint1998，，： | 1 |
| 8 | Key performance drivers for cooled large IR staring arrays显示文摘 | TRIBOLET P CHORIER P PISTONE F | 2003 | SPIE2003，5074，： | 1 |
| 9 | The role of DJ-1 complexes and catecholamine metabolism: relevance for familial and idiopathic Parkinson's disease显示文摘Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease(PD),while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.We have recently reported that | Dominik Piston Matthew E.Gegg | 2018 | Neural Regeneration Research2018，13，5： | 1 |
| 10 | p53 immunodetoction of liquid-based processed urinary samples helps to identify bladder tumors with a higher risk of progression显示文摘 | Piston E Faynel J | 2005 | Br J Cancer2005，93，2： | 1 |
| 11 | Generalised confounding with Grobner bases显示文摘 | Pistone G Wynn H P | 1996 | Biometrika1996，83，3： | 1 |
| 12 | Imaging live in cells and tissues by two-photon excitation mlcroscopy显示文摘 | Piston DW | 1999 | Trends Cell Biol1999，92，2： | 1 |
| 13 | Implementation of a near backscattering ima- ging system on the national ignition facility显示文摘 | MACKINNON A J McCARVILLE T PISTON K | 2004 | Review of Scientific Instruments2004，75，10： | 1 |
| 14 | L-Carnitine in the treatment of mild or moderate hepatic encephalopathy 显示文摘 | Malaguarnera M Pistone G Astuto M | 2003 | Dig Dis2003，21，3： | 1 |
| 15 | A DC Programming Heuristic Applied to the Logistics Network Design Problem 显示文摘 | THANH P N BOSTEL N PISTON 0 | 2012 | International Journal of Production Economics2012，135，1： | 1 |
| 16 | Wet air oxidation of p-coumaric acid over promoted ceria catalysts 显示文摘 | Neri G Pistone A Milone C | 2002 | Ap- plied Catalysis B : Environmental2002，38，4： | 1 |
| 17 | L-camitine decreas- es severity and type of fatigue induced by interferon-al- pha in the treatment of patients with hepatitis C显示文摘 | Neri S Pistone G Saraceno B | 2003 | Neu- ropsychobiology2003，47，2： | 1 |
| 18 | 2-photon molecular excitation provides intrinsic 3-dimensional resolution for laser-based microscopy and microphotochemistry显示文摘 | Williams RM Piston DW Webb WW | 1994 | FASEB J1994，8，： | 1 |
| 19 | A bioluminescence resonance energy transfer (BRET) system: application to interacting circadian clock proteins显示文摘 | Xu Y Piston D W Johnson C H | 1999 | Proc Nail Acad Sci U S A1999，96，1： | 1 |
| 20 | Lcptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis 显示文摘 | Gruen ML Hao M Piston DW | 2007 | Am J Physiol Cell Physiol2007，293，5： | 1 |
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