2篇
您的检索式：作者名="Alessandro Collo"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gender specific medicine in liver diseases:a point of view显示文摘Gender medicine focuses on the patho-physiological,clinical,prevention and treatment differences in diseases that are equally represented in men and women.The purpose of gender medicine is to ensure that each individual man and woman receives the best treatment possible based on scientific evidence.The concept of'gender'includes not only the sexual characteristics of individuals but also physiological and psychological attributes of men and women,including risk factors,protective/aggravating effects of sexual hormones and variances linked to genetics and corporal structures that explain biological and physiological differences between men and women.It is very important to consider all the biological,physiological,functional,psychological,social and cultural characteristics to provide patients with individualized disease management.Herein,we critically analyze the literature regarding gender differences for diseases and acquired conditions of the most representative hepatic pathologies:primary biliary cirrhosis,autoimmune hepatitis,primary sclerosing cholangitis,non alcoholic fatty liver disease and alcoholic liver disease,and viral chronic hepatitis B and C.The last section addresses hemochromatosis,which is a prevalent iron overload disorder in the Caucasian population.This review aims to describe data from the literature concerning viral chronic hepatitis during pregnancy,management during pregnancy and delivery,and new effective drugs for the prevention of maternal infection transmission without significant adverse effects or complications. | Marilena Durazzo Paola Belci Alessandro Collo Vanessa Prandi Erika Pistone Maria Martorana Roberto Gambino Simona Bo | 2014 | World Journal of Gastroenterology2014，20，9： | 3 |
| 2 | Can gender predict virological response to standard antiviral therapy for chronic hepatitis C? A retrospective study显示文摘Aim:The liver is a sexually dimorphic organ presenting gender differences in its metabolism,functions,enzyme activity,membrane lipid composition and immune response.This paper aimed to assess whether gender may predict virological response to standard antiviral therapy in subjects with chronic hepatitis C(CHC).Methods:The authors retrospectively analyzed 100 patients with genotype 1 CHC(55 men,45 women),who performed standard antiviral therapy(interferon and ribavirin for 12 months)in the period 2002-2012,evaluated with blood tests and abdominal ultrasound to compare different virological and biochemical response in both gender.Results:Rate of substained virological response(SVR)was higher,but not significant,in women than men(46.7%vs.34.5%,P=0.05);difference became significant after stratification by age(<50 and≥50 years).Specifically in the group aged under 50 years,rate of SVR was significantly higher in women than in men(66.7%vs.38.2%,P<0.05).Conclusion:Female gender may predict virological response to standard antiviral therapy in subjects with CHC aged below 50 years.Considering new potent and more expensive antiviral drugs actually available for HCV treatment,it could be useful to identify candidates firstly eligible to therapy. | Paola Belci Alessandro Collo Maria Martorana Andrea Evangelista Sara Giunti Roberto Gambino Maurizio Cassader Simona Bo Marilena Durazzo | 2016 | Hepatoma Research2016，2，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员