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| 1 | Structural basis for blocking PD-l-mediated immune suppression by therapeutic antibody pembrolizumab显示文摘 | Zhenkun Na Siok Ping Yeo Sakshibeedu R Bharath Matthew W Bowler Esra Ballkci Cheng-I Wang Haiwei Song | 2017 | Cell Research2017，27，1： | 10 |
| 2 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 3 | Prognostic value of perioperative leukocyte count in resectable gastric cancer显示文摘AIM: To investigate the prognostic significance of perioperative leukopenia in patients with resected gastric cancer.METHODS: A total of 614 eligible gastric cancer patients who underwent curative D2 gastrectomy and adjuvant chemotherapy were enrolled in this study. The relationship between pre- and postoperative hematologic parameters and overall survival was assessed statistically, adjusted for known prognostic factors.RESULTS: The mean white blood cell count(WBC) significantly decreased after surgery, and 107/614(17.4%) patients developed p-leukopenia, which was defined as a preoperative WBC ≥ 4.0 × 109/L and postoperative WBC < 4.0 × 109/L, with an absolute decrease ≥ 0.5 × 109/L. The neutrophil count decreased significantly more than the lymphocyte count. P-leukopenia significantly correlated with poor tumor differentiation and preoperative WBC. A higher preoperative WBC and p-leukopenia were independent negative prognostic factors for survival [hazard ratio(HR) = 1.602, 95% confidence interval(CI): 1.185-2.165; P = 0.002, and HR = 1.478, 95%CI: 1.149-1.902; P = 0.002, respectively] after adjusting for histology, Borrmann type, p TNM stage, vascular or neural invasion, gastrectomy method, resection margins, chemotherapy regimens, and preoperative WBC count. The patients with both higher preoperative WBC and p- leukopenia had a worse prognosis compared to those with lower baseline WBC and no p-leukopenia(27.5 mo vs 57.3 mo, P < 0.001). CONCLUSION: Preoperative leukocytosis alone or in combination with postoperative leukopenia could be independent prognostic factors for survival in patients with resectable gastric cancer. | Xiao-Feng Chen Jing Qian Dong Pei Chen Zhou Oluf Dimitri R?e Fang Zhu Shao-Hua He Ying-Ying Qian Yue Zhou Jun Xu Jin Xu Xiao Li Guo-Qiang Ping Yi-Qian Liu Ping Wang Ren-Hua Guo Yong-Qian Shu | 2016 | World Journal of Gastroenterology2016，22，9： | 4 |
| 4 | Characterization of soil organic matter fractions of tundra soils in Arctic Alaska by carbon 13 nuclear magnetic resonance spectroscopy 显示文摘 | Dai X Y Ping C L Candler R | 2001 | Soil Science Society of America Journal2001，65，： | 2 |
| 5 | The determinants of Chinese outward foreign direct investment显示文摘 | Peter J Buckley L JeremyClegg Adam R Cross Xin Liu Hinrich Voss and Ping Zheng | | 0，，： | 1 |
| 6 | IrrE, a global regulator of extreme radiation resistance inDeinococcus radiodurans, enhances salt tolerance in Escherichia coli and Brassica napus显示文摘 | Pan J Wang J Zhou Z Yan Y Zhang W Lu W Ping S Dai Q Yuan M Feng B Hou X Zhang Y Ma R Liu T Feng L Wang L Chen M Lin M | 2009 | PloS One2009，4，2： | 1 |
| 7 | Large eddy simulations and experimental studies of turbulent premixed combustion near extinction 显示文摘 | Wang Ping Zieker F Schieβl R Platova N A Fr?hlich J Maas U | 2013 | Proceedings of the Combustion Institute2013，34，1： | 1 |
| 8 | Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy显示文摘 | Takeishi Y Ping P Bolli R | 2000 | Circ Res2000，86，： | 1 |
| 9 | Genetic factors of susceptibility and of severity in primary biliary cirrhosis显示文摘 | Poupon R Ping C Chretien Y | 2008 | J Heoatolo2008，39，： | 1 |
| 10 | Patients at high risk of invasive fungal infections when and how to treat显示文摘 | Rüping MJ Vehreschild JJ Comely OA | 2008 | Drugs2008，68，14： | 1 |
| 11 | Exploring Spatial De- pendence of Cotton Yield Using Global and Local Autocorrela- tion Statistics 显示文摘 | Ping J L Green C J Zartman R E | 2004 | Field Crops Research2004，89，23： | 1 |
| 12 | Understanding information related fields : A conceptual framework 显示文摘 | Zhang Ping Benjamin R I | 2007 | Journal of the American Soci- ety for Information Science and Technology2007，58，13： | 1 |
| 13 | Highly dispersed palladium nanoparticles on ultra-porous silica mesocellular foam for the catalytic decarboxylation of stearic acid显示文摘 | PING E W WALLACE R PIERSON J | | 0，，1： | 1 |
| 14 | Targeting of mitochondria by 10-N-alkyl acridine orange analogues: Role of alkyl chain length in determining cellular uptake and localization 显示文摘 | Myriam E R Kashif A Zhang Ping | 2008 | Mitochondrion2008，8，3： | 1 |
| 15 | The Effects of Satisfaction and Struc- tural Constraints on Retailer Exiting, Voice,Loyal- ty, Opportunism,and Neglect显示文摘 | PING R A | 1993 | Journal of Retai- ling1993，69，3： | 1 |
| 16 | Risk factors for pe- rioperative morbidity and mortality after extended hepatectomy for hepatocellular car 2 cinoma显示文摘 | WeiAC Tung - Ping Poon R Fan ST | 2003 | Br Surg2003，90，： | 1 |
| 17 | Effect of combined use of nonionic surfactant on formation of oilin-water microemulsions显示文摘 | LI Ping GHOSH A WAGNER R F | 2005 | Int J Pharm2005，288，： | 1 |
| 18 | Gastrointestinal absorption enhancement of insulin by administration of enteric microspheres and SNAC to rats显示文摘 | Qi R Ping Q N | 2004 | J Microencapsul2004，21，1： | 1 |
| 19 | Thermodynamic modeling of petro- leum inclusions: The prediction of the saturation pressure of crude oils显示文摘 | Ping H Thiery R Chen H | 2011 | Geofluids2011，11，3： | 1 |
| 20 | Structural requirements for initiation of translation by interal ribosome entry within genomelength hepatitis C virus RNA显示文摘 | Honda M Ping L H Rijnbrand R A | 1996 | Virology1996，222，： | 1 |
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