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| 1 | Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance显示文摘The use of direct-acting antivirals(DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response(around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity of hepatitis C virus has resulted in the existence of resistance-associated variants(RAVs), sometimes even before starting treatment with DAAs, though generally at low levels. These preexisting RAVs do not appear to impact on the sustained viral response, whereas those that appear after DAA therapy could well be determinant in virological failure with future treatments. As well as the presence of RAVs, virological failure to treatment with DAAs is generally associated with other factors related with a poor response, such as the degree of fibrosis, the response to previous therapy, the viral load or the viral genotype. Nonetheless, viral breakthrough and relapse can still occur in the absence of detectable RAVs and after the use of highly effective DAAs, so that the true clinical impact of the presence of RAVs in therapeutic failure remains to be determined. | Miguel Jiménez-Pérez Rocío González-Grande Pilar Espana Contreras Isabel Pinazo Martínez Jesús de la Cruz Lombardo Raúl Olmedo Martín | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 2 | Compression medular pormetastasis departes dehepatocarcinoma 显示文摘 | Pinazo Seron MJ Benet A | 1999 | An Med Interna1999，16，1： | 1 |
| 3 | Amino acid-based surfactants显示文摘 | María Rosa Infante Lourdes Pérez Aurora Pinazo Pere Clapés María Carmen Morán Marta Angelet María Teresa García María Pilar Vinardell | 2004 | Comptes rendus - Chimie2004，，6： | 1 |
| 4 | Physicochemical and antimicrobial properties of new rhamnolipids produced by Pseudomonas aeruginosa AT10 from soybean oil refinery wastes显示文摘 | Abalos A Pinazo A Infante M R | 2001 | Langmuir2001，17，5： | 1 |
| 5 | Cationic surfactants derived from lysine : effects of their structure and charge type on antimicrobial and hemolytic activities 显示文摘 | Colomer A Pinazo A Manresa M A | 2011 | Med Chem2011，54，4： | 1 |
| 6 | Synthesis,surface active properties and antimicrobial activity of new bis quaternary ammonium compounds显示文摘 | Diz M Manresa A Pinazo A | 1994 | J Chem Soc Perken Trans1994，，8： | 1 |
| 7 | Physicochemical characteristics of liposomes formed with internal wool lipids显示文摘 | Coderch L De la Maza A Pinazo A | 1996 | Journal of the American Oil Chemists''Society1996，73，12： | 1 |
| 8 | Monoglyceride surfactants from arginine:synthesis and biological properties显示文摘 | Lourdes Perez Aurora Pinazo Maria Teresa | 2004 | New J Chem2004，28，： | 1 |
| 9 | Erosion of particulate inorganic and organic matter in the Gulf of Lion 显示文摘 | Schaaff E Grenz C Pinazo C | 2002 | Comptes Rendes Geoscience2002，334，15： | 1 |
| 10 | Spinal cord compression causedby metastasis ofsoft tissue hepatocarcinoma显示文摘 | Pinazo Seron MJ Benel A | 1999 | AnMed Interna1999，16，11： | 1 |
| 11 | Online chat rooms:virtual spaces of interaction for socially oriented People显示文摘 | PERIS R GIMENO M PINAZO D | 2002 | Cyberpsychology&Behavior2002，5，1： | 1 |
| 12 | Chagas disease in Spain, theUnited States, and other non-endemic countries 显示文摘 | Gascon J Bern C Pinazo M J | 2010 | ActaTrop2010，115，： | 1 |
| 13 | Compression medular pormetastasis departs dehepatocarcinoma 显示文摘 | Pinazo Seron M J Benel A | 1999 | An Med Intema1999，1，： | 1 |
| 14 | Evaluation of presumptive biomarkers of oxidative stress,immune response and apoptosis in primary open angle glaucoma显示文摘 | Pinazo-Duran MD Zanon-Moreno V Garcia-Medina J J Galleqo- Pinazo R | 2013 | Curt Opin Pharmacol2013，13，1： | 1 |
| 15 | Use of lipases for wool modificaiton 显示文摘 | Monlteo D Julia M R Pinazo A | 1994 | Melliand Textilberichte1994，75，5： | 1 |
| 16 | Physicochemical and antimicrobial properties of new rhamnolipids produced by Pseudomonas aeruginosa ATIO from soybean oil refinery wastes显示文摘 | ABALOS A PINAZO A INFANTE M R | 2001 | Langmuir2001，17，5： | 1 |
| 17 | Amino acid- based suffaetants显示文摘 | INFANTE M R PEREZ L PINAZO AURORA | 2004 | Comptes Rendus C himie2004，7，67： | 1 |
| 18 | Tolerance ofbenznidazole in treatment of Chagas1 disease in adults 显示文摘 | Pinazo M J Munoz J Posada E | 2010 | Antmicrob Agents Chemotherap2010，54，： | 1 |
| 19 | Spinal cord compression caused by metastasis of soft tissue hepatocarcinoma显示文摘 | Pinazo Serón MJ Beneti Català A Ferreri Santaularia J | | 0，，11： | 1 |
| 20 | Synthesis, surface active properties and antimicrobial activity of new bis quaternary ammonium compounds显示文摘 | DIZ M MANRESA A PINAZO A | 1994 | J Chem Soc1994，23，8： | 1 |
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