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| 1 | Alcoholic liver disease: A current molecular and clinical perspective显示文摘Heavy alcohol use is the cause of alcoholic liver disease(ALD).The ALD spectrum ranges from alcoholic steatosis to steatohepatitis,fibrosis,and cirrhosis.In Western countries,approximately 50%of cirrhosis-related deaths are due to alcohol use.While alcoholic cirrhosis is no longer considered a completely irreversible condition,no effective anti-fibrotic therapies are currently available.Another significant clinical aspect of ALD is alcoholic hepatitis(AH).AH is an acute inflammatory condition that is often comorbid with cirrhosis,and severe AH has a high mortality rate.Therapeutic options for ALD are limited.The established treatment for AH is corticosteroids,which improve short-term survival but do not affect long-term survival.Liver transplantation is a curative treatment option for alcoholic cirrhosis and AH,but patients must abstain from alcohol use for 6 months to qualify.Additional effective therapies are needed.The molecular mechanisms underlying ALD are complex and have not been fully elucidated.Various molecules,signaling pathways,and crosstalk between multiple hepatic and extrahepatic cells contribute to ALD progression.This review highlights established and emerging concepts in ALD clin-icopathology,their underlying molecular mechanisms,and current and future ALD treatment options. | Koichiro Ohashi Michael Pimienta Ekihiro Seki | 2018 | Liver Research2018，2，4： | 15 |
| 2 | Temperature, pore pressure and mass variation of concrete subjected to high temperature — Experimental and numerical discussion on spalling risk显示文摘 | Jean-Christophe Mindeguia Pierre Pimienta Albert Noumowé Mulumba Kanema | 2009 | Cement and Concrete Research2009，，3： | 2 |
| 3 | Generic detemfinacy of Nash equilibrium in network- formation games 显示文摘 | Carlos Pimienta | 2009 | Games and Economic Behavior Volume 66 Issue 2 July 20092009，，： | 1 |
| 4 | CO2 climate relationship as deduced from the Vostok ice core: a reexamina tion based on new measurements and on a reevaluation of the airdating显示文摘 | Banolar J M Pimienta P Raynaud D etal | 1991 | Tellus1991，19，11： | 1 |
| 5 | Tissue concentration of nanoeneapsulated radiolabelled eyelosprin following peroral delivery in mice or ophthalmic applications in rabbits显示文摘 | Bonduelle S Carrier M Pimienta C | 1996 | Eur J Biopharm1996，42，8： | 1 |
| 6 | Temper- ature,pore pressure and mass variation of concrete subjected to high temperature - Experimental and numerical discussion on spalling risk显示文摘 | MINDEGUIA J C PIMIENTA P NOUMOWE A | 2010 | Cement and Concrete Research2010，40，： | 1 |
| 7 | Proteomic characterization of Her2/neu-overexpressing breast cancer cells显示文摘 | Chen H Pimienta G Gu Y | 2010 | Proteomics2010，10，21： | 1 |
| 8 | Effect of various Poloxamer coatings on in vitro adhesion of isohexylcyanoacrylate nanospheres to rat ileal segments under liquid flow显示文摘 | Pimienta C Chouinard F Labib A | 1992 | Int J Pharm1992，80，： | 1 |
| 9 | Canonical and ahemative MAPK signaling 显示文摘 | PIMIENTA G PASCUAL J | 2007 | Cell Cycle2007，6，21： | 1 |
| 10 | Vostok ice core provides 160,000-year record of atmospheric CO2显示文摘 | BARMOLA J M PIMIENTA P RAYNAUDET D | 1987 | Nature1987，329，： | 1 |
| 11 | Temperature, pore pressure and mass variation of concrete subjected to high tempera- ture-experimental and numerical discussion on spalling risk 显示文摘 | Mindeguia J Pimienta P Noumowe A | 2010 | Cement and Concrete Research2010，40，3： | 1 |
| 12 | Genome-wide siR- NA screen identifies the retromer as a cellular entry fac- tor for human papillomavirus显示文摘 | Lipovsky A Popa A Pimienta G | 2013 | Proc Natl Acad Sci U S A2013，110，18： | 1 |
| 13 | Embryo sac development in almond Prunus dulcis(Mill) DA Webb as affected by cross-, self-and nonpoliination显示文摘 | PIMIENTA E POLITO V S | 1983 | Annals of Botany1983，51，： | 1 |
| 14 | Effects of various poloxamer coatings on in vitro adhesion of isohexylcyanoacrylate nanospheres to rat ileal segments under liquid flow 显示文摘 | Chouinard F Labib A | 1992 | Int J Pharm1992，80，： | 1 |
| 15 | Three-Dimensional Structure of the Siskin Green River Oil Shale Kerogen Model: A Comparison Be- tween Calculated and Observed Properties显示文摘 | Orendt A M Pimienta I S O Badu S R | 2013 | Ener- gy Fuels2013，27，2： | 1 |
| 16 | Effects of the Incorporation of Municipal Solid Waste Incineration Fly Ash in Cement Pastes and Mortars II Mod- eling显示文摘 | Remond S Bentz D P Pimienta P | 2002 | Cem Concr Res2002，32，： | 1 |
| 17 | Magnetic resonance imaging applications in early rheumatoid arthritis diagnosis and management显示文摘 | Troum OM Pimienta O Olech E | 2012 | Rheum Dis Clin North Am2012，38，2： | 1 |
| 18 | Mucoadhension of Hydropylmetthacrylate Nanoparticles to rat intestinal ileal segments in vitro显示文摘 | Pimienta C Lenaerts V Cadieux C | 1990 | Pharm Res1990，7，1： | 1 |
| 19 | SILAC for global phosphoproteomic analysis显示文摘 | Pimienta G Chaerkady R Pandey A | | 0，，： | 1 |
| 20 | Effect of various poloxamer coatings on in vitro adhesion of isohexyl cyanoacrylate nanospheres to rat ileal segments under liquid flow显示文摘 | Pimienta C Chouinard F Labib A | 1992 | Int J Pharm1992，80，1： | 1 |
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